Title status
Obsolete taxonomic
Latin name
Human echovirus
Parent taxon
Picornaviridae family
Human echovirus 1-9
Human echovirus 11— 27
Human echovirus 29—34
Echovirus eng ECHO, Enteric Cytopathic Human Orphan - a group of serotypes of RNA-containing viruses from the Picornaviridae1 family Echoviruses are found in the gastrointestinal tract, the virus causes opportunistic diseases - Contents
1 History
2 Description
3 The structure of the virus
4 Symptoms
5 Treatment
6 Notes
Echoviruses were first identified in the study e children who did not have symptoms of the disease in the early 1950s, “Echo” in the name of the taxon is an abbreviation for enteric cytopathic human orphan - “orphan virus” means: the virus is an orphan, that is, the virus is not associated with a known disease 2
Echoviruses - infectious diseases that predominantly infect children Echoviruses are the main cause of fever in newborns and children, as well as the most common cause of aseptic meningitis
Disease in children can lead to the development of systemic diseases and leads to mortality at an early age Echovirus infections may have symptoms of other infections caused by bacteria and viruses
Virus structure erected
Echovirus virion has a size of about 24-30 nm, has a protein capsid, which is up to 75% of the viral particle, and contains in the center single-stranded RNA Genomic RNA has a length of about 7.5 thousand bases, contains the RNA polymerase gene, viral proteins, as well as the polyprotein gene, from which the structural proteins necessary for replication in the cell are formed Structural proteins determine the specificity to the host’s body and play an important role in the delivery of genomic RNA to the cell cytoplasm. In some cases, virus replication after infection occurs in the nasopharynx then the viruses enter the lymph nodes. However, most of the virus particles are swallowed and they enter the gastrointestinal tract, where bind to specific receptors. Viruses enter the lower intestine, replicate there, but have no effect on cells. Viruses also enter many other parts of the body - the central nervous system, Virus, spleen, bone marrow, heart and lungs. Replication of the virus occurs within 4-6 days after infection, which causes the symptoms of the disease. Enteroviruses are extremely infectious and can infect almost any cell in the body. Viruses spread by airborne droplets within 1- 3 weeks after infection, as well as the fecal-oral route for up to 8 weeks after infection
Echoviruses mainly affect men and children, infection during the first two weeks after birth can lead to the death of a child In the youngest children, death usually occurs as a result of liver or myocarditis failure, but not as a result of central nervous system damage. Older children and adult patients have a good prognosis. Myocarditis is also the most common complication in adults. there is no specific method for treating echovirus infection. The antiviral drug pleconaril prevents the binding of echovirus particles to the cell membrane and the opening of virions
↑ Sherris Medical Microbiology / Ryan KJ; Ray CG - 4th - McGraw Hill, 2004 - P 537-539 - ISBN 0838585299
↑ Yin-Murphy M, Almond JW Picornavirues in: Baron's Medical Microbiology / Baron S et al - 4th - Univ of Texas Medical Branch, 1996 - ISBN ISBN 0-9631172-1-1
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