Wilder Penfieldwilder penfield, wilder penfield the mystery of the mind
Wilder Graves Penfield OM CC CMG FRS1 January 26, 1891 – April 5, 1976 was an American-Canadian pioneering neurosurgeon once dubbed "the greatest living Canadian"2 He expanded brain surgery's methods and techniques, including mapping the functions of various regions of the brain such as the cortical homunculus His scientific contributions on neural stimulation expand across a variety of topics including hallucinations, illusions, and déjà vu Penfield devoted a lot of his thinking to mental processes, including contemplation of whether there was any scientific basis for the existence of the human soul2
- 1 Biography
- 11 Early life and education
- 12 Medical career
- 13 Later life
- 2 Scientific contributions
- 21 Neural stimulation
- 22 Hallucinations
- 23 Déjà vu
- 3 Legacy
- 4 In popular culture
- 5 Notes
- 6 References
- 7 Selected books and publications
- 8 External links
Early life and educationeditPenfield at Princeton University in 1913
Penfield was born in Spokane, Washington on January 26,Notes 1 1891, but spent most of his early life in Hudson, Wisconsin2 He studied at Princeton University, where he was a member of Cap and Gown Club3 and played on the football team After graduation in 1913, he was hired briefly as the team coach In 1915 he obtained a Rhodes Scholarship to Merton College, Oxford,4 where he studied neuropathology under Sir Charles Scott Sherrington After one term at Merton, Penfield went to France where he served as a dresser in a military hospital in the suburbs of Paris4 He was wounded in 1916 when the ferry he was aboard, the SS Sussex, was torpedoed4 The following year, he married Helen Kermott, and began studying at the Johns Hopkins School of Medicine, taking his medical degree in 1918; this was followed by a short period as a house surgeon at the Peter Bent Brigham Hospital in Boston4 Returning to Merton College in 1919,4 Penfield spent the next two years completing his studies; during this time he met William Osler In 1924, he worked for five months with Pío del Río Hortega characterising the type of glial cells known as oligodendroglia5 He also studied in Germany and New York City6
After taking a surgical apprenticeship under Harvey Cushing, he obtained a position at the Neurological Institute of New York, where he carried out his first solo operations to treat epilepsy While in New York, he met David Rockefeller, who wished to endow an institute where Penfield could further study the surgical treatment of epilepsy Academic politics amongst the New York neurologists, however, prevented its establishment in New York, so, in 1928, Penfield accepted an invitation from Sir Vincent Meredith to move to Montreal There, Penfield taught at McGill University and the Royal Victoria Hospital, becoming the city's first neurosurgeon
In 1934, Penfield founded and became the first director of the Montreal Neurological Institute and Hospital4 at McGill University, established with the Rockefeller funding That year, he also became a Canadian citizen4clarification needed
Penfield was elected a Foreign Honorary Member of the American Academy of Arts and Sciences in 19507 and retired ten years later in 1960 He was appointed to the Order of Merit in the 1953 New Year Honours list He turned his attention to writing, producing a novel as well as his autobiography No Man AloneNotes 2
In 1960, the year he retired, Penfield was awarded the Lister Medal for his contributions to surgical science8 He delivered the corresponding Lister Oration, "Activation of the Record of Human Experience", at the Royal College of Surgeons of England on April 27, 19619 In 1967, he was made a Companion of the Order of Canada and, in 1994, was posthumously inducted into the Canadian Medical Hall of Fame Much of his archival material is housed in the Osler Library at McGill University
In his later years, Penfield dedicated himself to the public interest, particularly in support of university education With his friends Governor-General Georges Vanier and Pauline Vanier, he co-founded the Vanier Institute of the Family "to promote and guide education in the home – man's first classroom"citation needed He was also an early proponent of childhood bilingualism
Penfield died on April 5, 1976, of abdominal cancer at Royal Victoria Hospital in Montreal210
Penfield was a groundbreaking researcher and original surgeon With his colleague Herbert Jasper, he invented the Montreal procedure in which he treated patients with severe epilepsy by destroying nerve cells in the brain where the seizures originated Before operating, he stimulated the brain with electrical probes while the patients were conscious on the operating table under only local anesthesia, and observed their responses In this way he could more accurately target the areas of the brain responsible, reducing the side-effects of the surgery
This technique also allowed him to create maps of the sensory and motor cortices of the brain see cortical homunculus showing their connections to the various limbs and organs of the body These maps are still used today, practically unaltered Along with Herbert Jasper, he published this work in 1951 2nd ed, 1954 as the landmark Epilepsy and the Functional Anatomy of the Human Brain This work contributed a great deal to understanding the localization of brain function Penfield's maps showed considerable overlap between regions ie the motor region controlling muscles in the hand sometimes also controlled muscles in the upper arm and shoulder a feature which he put down to individual variation in brain size and localisation: it has since been established that this is due to the fractured somatotropy of the motor cortex From these results he developed his cortical homunculus map, which is how the brain sees the body from an inside perspective11
Penfield reported12 that stimulation of the temporal lobes could lead to vivid recall of memories Oversimplified in popular psychology publications, including the best-selling I'm OK – You're OK, this seeded the common misconception that the brain continuously "records" experiences in perfect detail, although these memories are not available to conscious recall Reported episodes of recall occurred in less than five percent of his patients, though these results have been replicated by modern surgeons1314 Penfield's hypothesis on this subject was revised in 197015 His development of the Penfield dissector, the neurosurgical technique that produced the less injurious meningo-cerebral scar, became widely accepted in the field of neurosurgery and remains in regular use
Penfield's scientific contributions go past the somatosensory and the motor cortices, his extensive work of the functions of the brain also included charting the functions of the parietal and temporal cortices16 Of his 520 patients, 40 reported that while their temporal lobe was stimulated with an electrode they would recall dreams, smells, visual and auditory hallucinations, as well as out-of-body experiences17 In his studies, Penfield found that when the temporal lobe was stimulated it produced a combination of hallucinations, dream, and memory recollection18 These experiences would only last as long as the electrode stimulations were present on the cortex, and in some cases when patient experienced hallucinatory experiences that evoked certain smells, sensations of flashing light, stroking the back of their hand, and many others Other stimulations had patients experiencing deja vu, fear, loneliness, and strangeness Certain areas of patients' temporal lobes were stimulated with an electrode in order to experience past memories Penfield called these perceptual illusions physical hallucinations interpretive responses According to Penfield, when the temporal lobe was stimulated there were two types of perceptions experienced by patients:19
- Experential experience – where the patient recorded hearing a song, or seeing a flash of light
- Strip experience – The recall seems familiar to the patient and comes from the patient's past even though the patient may not be able to pinpoint the exact occasion The recall of a memory or memories could reenforce the emotion tied to the experience
Penfield stressed that the "things that have been recorded are the things in which once came within the spot-light of attention"19 Penfield had over 25 years of research using electrical stimulation to produce experiential hallucinations His conclusions show that patients experience a range of hallucinations from simple to complex20
Penfield's expansion of the interpretive cortex includes the phenomena of déjà vu21 Déjà vu is defined as the sensation that an experience an individual is presently experiencing has previously been experienced22 Déjà vu is typically experienced by individuals between the ages of 15 to 25, and only affects approximately 60-70% of individuals It is thought to be a mismatch of the sensory input individuals receive and the system in which the brain recalls memory Another thought on the cause of déjà vu is that there is a malfunction in the brain's short- and long-term memory systems where memories become stored in incorrect systems23 There are a couple of ways one can recognize familiar experiences – by mentally retrieving memories of a previous experience, or by having a feeling that an experience has occurred when it actually has not Déjà vu is having that feeling of familiarity in a situation that is completely new Memory is good at being familiar with objects, however it does not do well with the configuration or organization of objects Déjà vu is an extreme reaction to the mind telling an individual that they are having a familiar experience24 Déjà vu is thought to be a consistent phenomenon However, it has been associated with epilepsy, and with multiple psychiatric disorders such as schizophrenia and anxiety,22 but there has not been a clear, frequent diagnostic correlation between déjà vu and neurological or psychiatric disorders, except with patients that have a possibility of being epileptic25 Temporal lobe epilepsy affects the hippocampus Patients that suffer from this medical diagnosis are said to have a misfiring of the brain's neurons The neurons transmit at random which results in the false sense of experiencing a familiar situation that had previously been experienced26 Different types of déjà vu are difficult to pinpoint because researchers who have studied déjà vu have developed their own categories and differentiations On a broad perspective of research that is available, déjà vu can be divided into two categories associative déjà vu and biological déjà vu Associative déjà vu is typically experienced by normal, healthy individuals who experience things with the senses that can be associated to other experiences or past events Biological déjà vu occurs in individuals who suffer from temporal lobe epilepsy27 Their experience of déjà vu occurs usually just before they experience a seizure28 Recent research is looking at the new occurrence of chronic déjà vu Chronic déjà vu is when an individual is experiencing a constant state of déjà vu Failure of the temporal lobe is thought to be the cause of this phenomenon because the circuits that connect to memories get stuck in an active state, and create memories that never happened28
Avenue du Docteur-Penfield 45°30′01″N 73°34′59″W / 45500342°N 73583103°W / 45500342; -73583103, on the slope of Mount Royal in Montreal, was named in Penfield's honour on October 5, 1978 Part of this avenue borders McGill University's campus and intersects with Promenade Sir-William-Osler – meaning medical historians and the like may amuse themselves by arranging to "meet at Osler and Penfield" A portrait of Wilder Penfield hangs in Rhodes House, Oxford Penfield was elected a Fellow of the Royal Society FRS in 19431
Wilder Penfield Elementary school was also established as part of the Lester B Pearson School Board in honour of Wilder Graves Penfield's contribution to the public sector in Montreal, notably alongside his interest in further developing education
In popular cultureedit
- Wilder Penfield was the subject of a Heritage Minute, dramatizing his development of the Montreal procedure When Dr Penfield stimulates the seizure-producing part of her brain, an epileptic patient exclaims: "I can smell burnt toast!" This Heritage Minute was widely shown and again made Penfield a household name in Canada
- In Chapter 14 of Robert J Sawyer's 2012 novel Triggers, it is revealed that the major character of Dr Ranjip Singh, a Canadian, was inspired to pursue his career in neuroscience by having seen the "I can smell burnt toast" Heritage Minute about Penfield
- In science fiction author Philip K Dick's Do Androids Dream of Electric Sheep, characters use a household device called a Penfield Mood Organ to dial up emotions on demand
- The principal character in J G Ballard's novel Super-Cannes is a manipulative psychiatrist named Wilder Penrose
- Shirow Masamune's anime series Ghost Hound makes several references to Penfield and his studies
- The song "Wilder Penfield" by the Dead Sea Apes, a UK-based psychedelic rock, from The Sun Behind The Sun, a collaboration with Black Tempest released in February 2013 on Cardinal Fuzz records29
- In Ray Loriga's 1999 novel Tokio ya no nos quiere, Penfield's method of stimulating the temporal lobes is described and modified to treat the main character who has issues with memory recollection
- In the video game Xenosaga Episode I: Der Wille zur Macht, "Penfield Mapping" is seemingly the process of drawing a cortical homunculus, necessary for one to enter a virtual environment
- Wilder Penfield's, Sensory & Motor Homunculus 3D figures have been on permanent exhibition in the Natural History Museum LondonWilder Penfield's Homunculi have become loved exhibits which have garnered a cult following globally
- ^ January 26 was the date supplied on his World War I draft registration, but other sources have January 25 see PBS reference
- ^ A later biography, Something Hidden, was written by his grandson Jefferson Lewis
- ^ a b c Eccles, John; Feindel, William 1978 "Wilder Graves Penfield 26 January 1891-5 April 1976" Biographical Memoirs of Fellows of the Royal Society Royal Society 24: 472–513 doi:101098/rsbm19780015
- ^ a b c d "Wilder Penfield" PBS Retrieved 2010-02-07 Wilder Penfield was born in Spokane, Washington, and spent much of his youth in Hudson, Wisconsin During his life he was called "the greatest living Canadian"
- ^ Shenstone, Allen Goodrich Autumn 1982 "Princeton 1910–1914" PDF Princeton University Library Chronicle 44 1: 25–41 Retrieved 2013-11-26
- ^ a b c d e f g Levens, RGC, ed 1964 Merton College Register 1900–1964 Oxford: Basil Blackwell pp 102–103
- ^ Gill, AS; DK Binder May 2007 "Wilder Penfield, Pío del Río-Hortega, and the discovery of oligodendroglia" Neurosurgery 60 5: discussion 940–8 doi:101227/01NEU00002554489773034 PMID 17460531
- ^ "Wilder Penfield" Princeton University Retrieved 2010-02-07
- ^ "Book of Members, 1780–2010: Chapter P" PDF American Academy of Arts and Sciences Retrieved 15 April 2011
- ^ "Lister Medal" Ann R Coll Surg Engl 28: 15 PMC 2414022 PMID 19310274
- ^ Penfield Wilder August 1961 "Activation of the Record of Human Experience" Ann R Coll Surg Engl 29 2: 77–84 PMC 2414108 PMID 19310299
- ^ "W G Penfield, Neurologist, Dies Refined Techniques to Treat Epilepsy Founded an Institute in Montreal" New York Times April 5, 1976 Retrieved 2010-02-07 Dr Wilder G Penfield, one of the world's foremost neurologists who honed surgical techniques for treating epilepsy, died yesterday of abdominal cancer at Royal Victoria Hospital in Montreal He was 85 years old
- ^ "How your brain sees your body: Meet the cortical homunculus"
- ^ Penfield, W Memory Mechanisms AMA Archives of Neurology and Psychiatry 671952: 178–198
- ^ Maillard, Louis; McGonigal, Aileen; Chauvel, Patrick; Vignal, Jean-Pierre 2006 "The dreamy state: hallucinations of autobiographic memory evoked by temporal lobe stimulations and seizures" Brain 130 1: 88–89 doi:101093/brain/awl329 PMID 17142246 spread of the discharge to the temporal neocortex appeared to prevent the occurrence of the dreamy state Semiological analysis showed a clinical continuity between déjà vécu and visual hallucinations, the latter often consisting of a personal memory that was 'relived' by the subject; such memories could be recent, distant or from childhood With one exception, the particular memory evoked differed from one seizure to another, but were always drawn from the same period of the subject's life Lay summary Check |laysummary= value help
- ^ F Bartolomei, MD 2004 "Cortical stimulation study of the role of rhinal cortex in déjà vu and reminiscence of memories" Neurology 63 5: 858–864 doi:101212/01wnl0000137037569163f Lay summary Entorhinal and perirhinal stimulations induced classic mesial temporal lobe responses emotional, dysautonomic but also more specific responses, particularly the déjà vu phenomenon and reminiscence of scenes
- ^ Horowtiz, MJ; Adams, JE 1970 "Hallucinations on Brain Stimulation; Evidence for Revision of The Penfield Hypothesis" Origin and mechanism of Hallucinations Plenum Press
- ^ 1
- ^ Tong, Frank 2003 "Out-of-body experiences: from Penfield to present" Trends in Cognitive Sciences 7 3: 104–106 doi:101016/s1364-66130300027-5 Lay summary A research report in 2002 described "a patient who reported spontaneous out-of-body experiences during electrical stimulation of her angular gyrus These findings, although apparently extraordinary, agree with much earlier reports from a patient tested by Wilder Penfield"
- ^ 2
- ^ a b 3
- ^ 4
- ^ Bancaud, J; Brunet-Bourgin, F; Chauvel, P; Halgren, E 1994 "Anatomical origin of déjà vu and vivid 'memories' in human temporal lobe epilepsy" Brain : a journal of neurology 117 Pt 1: 71–90 doi:101093/brain/117171 PMID 8149215 Lay summary seizures arising in the medial temporal lobe may result in a 'dreamy state', consisting of vivid memory-like hallucinations, and/or the sense of having previously lived through exactly the same situation déjà vu Penfield demonstrated that the dreamy state can sometimes be evoked by electrical stimulation of the lateral temporal neocortex, especially the superior temporal gyrus
- ^ a b Déjà vu
- ^ "The Neuroscience of Déjà Vu"
- ^ "What Is Déjà Vu"
- ^ "Déjà vu in neurology"
- ^ "What Is Déjà Vu"
- ^ Labate, Angelo; Cerasa, Antonio; Mumoli, Laura; Ferlazzo, Edoardo; Aguglia, Umberto; Quattrone, Aldo; Gambardella, Antonio 2015 "Neuro-anatomical differences among epileptic and non-epileptic déjà-vu" Cortex; a journal devoted to the study of the nervous system and behavior 64: 1–7 doi:101016/jcortex201409020 Lay summary individuals with epilepsy with DV Deja vu versus those without DV Deja vu revealed abnormal anatomical changes in the left hippocampus
- ^ a b "How Déjà Vu Works"
- ^ "Wilder Penfield" soundcloudcom Retrieved 4 October 2012
Selected books and publicationsedit
- Epilepsy and Cerebral Localization: A Study of the Mechanism, Treatment and Prevention of Epileptic Seizures Penfield, W, and Theodore C Erickson Charles C Thomas, 1941
- Epilepsy and the Functional Anatomy of the Human Brain 2nd edition Jasper, H, and Penfield, W Little, Brown and Co, 1954 ISBN 0-316-69833-4
- The Torch Penfield, W Little, Brown and Co; 1960 ISBN 1-299-80119-6 "A story of love, treachery, and the battle for truth in ancient Greece"
- The Mystery of the Mind : A Critical Study of Consciousness and the Human Brain Penfield, Wilder Princeton University Press, 1975 ISBN 0-691-02360-3
- No Man Alone: A Surgeon's Life, Little, Brown and Co, 1977 ISBN 0-316-69839-3 Penfield's autobiography
- Something hidden : a biography of Wilder Penfield Jefferson Lewis, Doubleday and Co, 1981 ISBN 0-385-17696-1
- Speech and Brain Mechanisms, Penfield, Wilder and Roberts, Lamar, Princeton University Press, 1959
|Wikimedia Commons has media related to Wilder Penfield|
- Famous Canadian Physicians: Dr Wilder Penfield at Library and Archives Canada
- Penfield's Order of Canada citation
- Penfield Fonds at the Osler Library of the History of Medicine
- Searchable Penfield-related data in the Osler Library database
- Selection of items from the Fond have been digitized in http://digitallibrarymcgillca/penfieldfonds/
- Penfield biography at the "Great Canadian Psychology" website University of Alberta
- Wilder Graves Penfield, MD, OM, CC, FRS, 1891-1976 / text by Kate Williams and Wilder G Penfield III
A Maude Elizabeth Seymour Abbott
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