Warthin's tumorwarthin's tumor surgery, warthin's tumor
Warthin's tumor, also known as papillary cystadenoma lymphomatosum, is a benign cystic tumor of the salivary glands containing abundant lymphocytes and germinal centers lymph node-like stroma It is named for pathologist Aldred Scott Warthin, who described two cases in 19291 Play media Video explanation
- 1 Signs and symptoms
- 11 Locations
- 2 Cause
- 3 Diagnosis
- 4 Treatment
- 5 See also
- 6 References
- 7 Additional sources
- 8 External links
Signs and symptomsedit
Warthin's tumor primarily affects older individuals age 60–70 years There is a slight male predilection according to recent studies The tumor is slow growing, painless, and usually appears in the tail of the parotid gland near the angle of the mandible In 5–14% of cases, Warthin's tumor is bilateral, but the two masses usually are at different times Warthin's tumor is highly unlikely to become malignant
The gland most likely affected is the parotid gland In fact, it is the only tumor virtually restricted to the parotid gland Though much less likely to occur than pleomorphic adenoma, Warthin's tumor is the second most common benign parotid tumor
Its cause is unknown, but there is a strong association with cigarette smoking Smokers are at 8 times greater risk of developing Warthin's tumor than the general population2
The appearance of this tumor under the microscope is unique There are cystic spaces surrounded by two uniform rows of epithelial cells with centrally placed pyknotic nuclei The cystic spaces have epithelium referred to as papillary infoldings that protrude into them Additionally, the epithelium has lymphoid stroma with germinal center formation
The differential diagnosis includes sebaceous lymphadenoma and oncocytoma
Low magnification micrograph of a Warthin tumor arising from the parotid gland
Histopathology of Warthin tumor in the parotid gland H&E stain
Histopathology of Warthin tumor in the parotid gland Another view of a file "Warthin tumor 1jpg" H&E stain
Histopathology of Warthin tumor in the parotid gland Higher magnification of a file "Warthin tumor 1jpg" H&E stain
Intermediate magnification micrograph of a Warthin tumor
High magnification micrograph of a Warthin tumor showing the characteristic bilayered epithelium
Most of these tumors are treated with surgical removal It is non recurrent
- Pleomorphic adenoma
- ^ Witt, Robert L, ed 2005 "Chapter 9 "Benign tumors, cysts, and tumor-like conditions of the salivary glands" Salivary Gland Diseases: Surgical and Medical Management New York: Thieme Medical Publishers p 123 ISBN 1-58890-414-8
- ^ Kumar V, Abbas AK, Fausto N 2005 Robbins and Cotran pathologic basis of disease 7th ed St Louis, MO: Elsevier Saunders ISBN 0-7216-0187-1
- Kahn, Michael A Basic Oral and Maxillofacial Pathology Volume 1 2001
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|See also Template:Epithelium and epithelial tissue|
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