Venezuelan equine encephalitis virusvenezuelan equine encephalitis virus, venezuelan equine encephalitis virus vaccine
Venezuelan equine encephalitis virus is a mosquito-borne viral pathogen that causes Venezuelan equine encephalitis or encephalomyelitis VEE VEE can affect all equine species, such as horses, donkeys, and zebras After infection, equines may suddenly die or show progressive central nervous system disorders Humans also can contract this disease Healthy adults who become infected by the virus may experience flu-like symptoms, such as high fevers and headaches People with weakened immune systems and the young and the elderly can become severely ill or die from this disease
The virus that causes VEE is transmitted primarily by mosquitoes that bite an infected animal and then bite and feed on another animal or human The speed with which the disease spreads depends on the subtype of the VEE virus and the density of mosquito populations Enzootic subtypes of VEE are diseases endemic to certain areas Generally these serotypes do not spread to other localities Enzootic subtypes are associated with the rodent-mosquito transmission cycle These forms of the virus can cause human illness but generally do not affect equine health
Epizootic subtypes, on the other hand, can spread rapidly through large populations These forms of the virus are highly pathogenic to equines and can also affect human health Equines, rather than rodents, are the primary animal species that carry and spread the disease Infected equines develop an enormous quantity of virus in their circulatory system When a blood-feeding insect feeds on such animals, it picks up this virus and transmits it to other animals or humans Although other animals, such as cattle, swine, and dogs, can become infected, they generally do not show signs of the disease or contribute to its spread
The virion is spherical and approximately 70 nm in diameter It has a lipid membrane with glycoprotein surface proteins spread around the outside Surrounding the nuclear material is a nucleocapsid that has an icosohedral symmetry of T = 4, and is approximately 40 nm in diameter
- 1 Viral subtypes
- 2 Venezuelan equine encephalitis outbreaks
- 21 Vaccine
- 3 Use as a biological weapon
- 4 Recent news
- 5 References
- 6 Notes
- 7 External links
Serology testing performed on this virus has shown the presence of six different subtypes classified I to VI1 These have been given names, including Mucambo, Tonate, and Pixuna subtypes There are seven different variants in subtype I, and three of these variants, A, B, and C are the epizootic strains
The Mucambo virus subtype III appears to have evolved ~1807 AD 95% credible interval: 1559–19442 In Venezuela the Mucambo subtype was identified in 1975 by Jose Esparza and J Sánchez using cultured mosquito cells3
Venezuelan equine encephalitis outbreaksedit
In the Americas, there have been 21 reported outbreaks of Venezuelan Equine Encephalitis Virus4 Outbreaks of Venezuelan equine encephalitis virus occurred in Central American and South American countries This virus was isolated in 1938, and outbreaks have been reported in many different countries since then Mexico, Colombia, Venezuela, and the United States are just some of the countries that have reported outbreaks5 Outbreaks of VEE generally occur after periods of heavy precipitation that cause mosquito populations to thrive4
Between December 1992 and January 1993, the Venezuelan state of Trujillo experienced an outbreak of this virus Overall, 28 cases of the disease were reported along with 12 deaths June 1993 saw a bigger outbreak, as 55 humans died as well as 66 equine deathscitation needed
A much larger outbreak in Venezuela and Colombia occurred in 1995 On May 23, 1995, equine encephalitis-like cases were reported in the northwest portion of the country Eventually, the outbreak spread more towards the north as well as to the south The outbreak caused about 11,390 febrile cases in humans as well as 16 deaths About 500 equine cases were reported with 475 deaths67 Washington, DC, USA: Pan American Health Organization, Pan American Sanitary Bureau, Regional Office of the World Health Organization, 2001 Print</ref>
An outbreak of this disease occurred on Colombia in September 1995 This outbreak resulted in 14,156 human cases that were attributable to Venezuelan equine encephalitis virus with 26 human deaths8 A possible explanation for the serious outbreaks was the particularly heavy rain that had fallen This could have caused increased numbers of mosquitoes that could serve as vectors for the disease A more likely explanation is that deforestation caused a change in mosquito species Culex taenopius mosquitos, which prefer rodents, were replaced by Aedes taeniorhynchus mosquitos, which are more likely to bite humans and large equines
Though the majority of VEE outbreaks occur in Central and South America, the virus has potential to outbreak again in the United States It has been shown the invasive mosquito species Aedes albopictus is a viable carrier of VEEV8
There is a vaccine containing the C-84 strain for VEEV that is used to immunize horses Another vaccine containing the TC-83 strain is only used on humans in military and laboratory positions that risk contracting the virus The human vaccine can result in side effects and does not fully immunize the patient The TC-83 strain is generated by passing the virus 83 times through the heart cells of a guinea pig; C-84 is a derivative of TC-839
Use as a biological weaponedit
During the Cold War, both the United States biological weapons program and the Soviet biological weapons program researched and weaponized VEE10
In April 2009, the US Army Medical Research Institute of Infectious Diseases at Fort Detrick reported that samples of Venezuelan equine encephalitis virus were discovered missing during an inventory of a group of samples left by a departed researcher The report stated the samples were likely among those destroyed when a freezer malfunctioned11
- ^ https://wwwresearchgatenet/publication/248587770_Gernot_H_Bergold_1911-2003
- ^ Auguste AJ, Volk SM, Arrigo NC, Martinez R, Ramkissoon V, Adams AP, Thompson NN, Adesiyun AA, Chadee DD, et al 2009 "Isolation and phylogenetic analysis of Mucambo virus Venezuelan equine encephalitis complex subtype IIIA in Trinidad" Virology 392 1: 123–130 PMC 2804100 PMID 19631956 doi:101016/jvirol200906038
- ^ Esparza, J; Sánchez, A 1975 "Multiplication of Venezuelan equine encephalitis Mucambo virus in cultured mosquito cells" Archives of Virology 49 2–3: 273–80 PMID 813617 doi:101007/bf01317545 Retrieved July 7, 2014
- ^ a b Weaver, SC; Ferro, C; Barrera, R; Boshell, J; Navarro, JC 2004 "Venezuelan equine encephalitis" Annual Review of Entomology 49: 141–174
- ^ Beran, George W Handbook of zoonoses Boca Raton, Fla: CRC Press, 1994 Print
- ^ Acha, Pedro N, and Boris Szyfres Zoonoses and communicable diseases common to man and animals
- ^ Pfau, CJ, Bergold, GH, Casals, J, Johnson, KM, Murphy, FA,Pedersen, IR, Rawls, WE, Rowe, WP, Webb, PA, Weissenbacher, MC, 1974 Arenaviruses Intervirol 4, 207–213 Gernot H Bergold 1911–2003 PDF Download Available Available from: https://wwwresearchgatenet/publication/248587770_Gernot_H_Bergold_1911-2003 accessed May 11, 2017
- ^ a b Beaman, JR; Turell, MJ 1991 "Transmission of Venezuelan Equine Encephalomyelitis Virus by Strains of Aedes albopictus Diptera: Culicidae Collected in North and South America" Journal of Medical Entomology 28: 161–164 doi:101093/jmedent/281161
- ^ "Venezuelan equine encephalitis virus"
- ^ Croddy, Eric C and Hart, C Perez-Armendariz J, Chemical and Biological Warfare, Google Books, Springer, 2002, pp 30-31, ISBN 0387950761, accessed October 24, 2008
- ^ Army: 3 vials of virus samples missing from Maryland facility, via CNNcom
- APHIS 1996 Venezuelan Equine Encephalomyelitis
- "PAHO: Equine Encephalitis in the Event of a Disaster" Retrieved 2007-03-17
- "PAHO Epidemiological Bulletin: Outbreak of Venezuelan Equine Encephalities" Retrieved 2007-03-17
- "PATHINFO: Venezuelan Equine Encephalitis Virus" Retrieved 2007-03-17
- Esparza J, Sánchez A 1975 "Multiplication of Venezuelan Equine Encephalitis Mucambo virus in cultured mosquito cells" Arch Virol 49 2–3: 273–80 PMID 813617 doi:101007/BF01317545
- "Army: 3 vials of virus samples missing from Maryland facility" CNN 2009-04-22 Retrieved 2009-04-23
- Disease card on World Organisation for Animal Health
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