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Vaginal flora

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Vaginal flora or vaginal microbiota are the microorganisms that colonize the vagina It was discovered by the German gynecologist Albert Döderlein in 1892, and are part of the overall human flora The amount and type of bacteria present have significant implications for a woman's overall health The primary colonizing bacteria of a healthy individual are of the genus Lactobacillus, such as L crispatus, and the lactic acid they produce is thought to protect against infection by pathogenic species


  • 1 Lactobacilli
    • 11 The production of lactic acid
    • 12 Hydrogen peroxide
    • 13 Bacteriocins
  • 2 Other microbiota
  • 3 Other vaginal bacterial species
  • 4 Pregnancy
  • 5 Disease prevention
  • 6 Research
  • 7 See also
  • 8 References
  • 9 External links


The primary colonizing bacteria of a healthy individual are of the genus Lactobacillus Since the first description of lactobacilli by Döderlein, lactobacilli have been generally considered as the gatekeepers of the vaginal ecosystem Lactobacilli have been shown to inhibit in vitro growth of pathogenic microorganisms, eg Bacteroides fragilis, Escherichia coli, Gardnerella vaginalis, Mobiluncus spp, Neisseria gonorrhoeae, Peptostreptococcus anaerobius, P bivia and Staphylococcus aureus It is generally accepted that this is achieved mainly through the action of lactic acid Moreover, lactobacilli normally help to prevent long-term colonization of the vagina by adhering to vaginal epithelial cells This usually reduces pathogens from infecting to the vaginal epithelium

Next to lactic acid production and competition for adherence, other antagonistic mechanisms include hydrogen peroxide a broad-spectrum antimicrobial and bacteriocins target-specific antimicrobials production

The production of lactic acid

Glycogen is the complex form of sugar present in the vaginal epithelium that is metabolized into lactic acid

Low pH is generally accepted to be the main mechanism controlling the composition of the vaginal microflora Although the lactic acid produced by lactobacilli contributes to the vaginal acidity, it is still not proven to be the primary source of low vaginal pH, but the fact remains that most lactobacilli thrive best at a pH < 45

Hydrogen peroxide

Production of hydrogen peroxide H2O2 is a well-known mechanism for bacterial antagonism, inhibiting growth of microorganisms via direct interaction or via human myeloperoxidase Hydrogen peroxide-producing lactobacilli have been shown to inactivate HIV-1, herpes simplex virus type 2 HSV-2, Trichomonas vaginalis, G vaginalis, P bivia and E coli O'Hanlon and Baeten found that 96% of Lactobacillus species from a healthy vaginal ecosystem produced H2O2 L jensenii and L vaginalis produce the highest levels of H2O2, whereas only 6% of the lactobacilli recovered from women with BV produced H2O2 In agreement with this, L iners, most frequently associated with disturbed vaginal microflora, is a poor producer of H2O2 Vaginal colonization by H2O2-producing lactobacilli has been associated with a decrease in the occurrence of bacterial vaginosis BV However, more recently O‘Hanlon et al demonstrated that cervicovaginal fluid and semen have a significant H2O2-blocking activity and they laterdemonstrated that physiological concentrations of H2O2 below 100 μM fail to inactivate any of the 17 tested BV-associated bacteria, eg A vaginae, G vaginalis, Mobiluncus spp, P bivia, Prevotella corporis, Mycoplasma hominis, even in the presence of human myeloperoxidase, known to increase the microbicidal activity of H2O2 Only supraphysiologic concentrations of exogenous H2O2 034% w/v, 100 mM were sufficient to inactivate BV-associated bacteria at which concentration it more potently inactivated vaginal lactobacilli L crispatus, L gasseri, L iners and L jensenii A concentration of 100 mM H2O2 is approximately 50-fold higher than lactobacilli are capable of producing even under optimal aerobic, low-antioxidant conditions, and approximately 5,000-fold higher than the estimated H2O2 concentration in vivo Even more remarkable, the addition of only 1% vaginal fluid blocked the microbicidal activity of 1 M H2O2 Possible explanations may be that cervicovaginal fluid and semen contain proteins, glycoproteins, polysaccharides, lipids, and other molecules with the potential to react with and inactivate H2O2 In addition, the vagina is hypoxic most of the time, whereas lactobacilli require oxygen to produce hydrogen peroxide It is also remarkable that catalase, which provides bacteria protection against toxic H2O2, is absent in lactobacilli, and as such they would be unprotected against their own H2O2 production In contrast, under optimal anaerobic growth conditions, physiological concentrations of lactic acid inactivated the BV-associated pathogens without affecting the vaginal lactobacilli In summary, although the hydrogen peroxide production of lactobacilli has been considered as an important antimicrobial component, contributing to the colonization resistance provided by lactobacilli, and although there seems to be a link between H2O2-producing lactobacilli and normal vaginal microflora, recent data do not support this role for H2O2


Vaginal lactobacilli produce antimicrobial peptides, ie bacteriocins such as lactocin 160 and crispasin with inhibitory activity ranging from narrow closely related Lactobacillus species to broad diverse groups of bacteria, including G vaginalis and P bivia, and bacteriocin-like substances, with a broader spectrum of activity than bacteriocins eg a heat-resistant peptide produced by Lactobacillus salivarius subsp salivarius CRL 1328 Several studies have indicated that the activity of bacteriocins is favored by low pH

The inhibitory substances produced by vaginal Lactobacillus is a primary factor in protecting the vaginal microbiota, with organic acids, bacteriocins, and hydrogen peroxide These act synergistically against infection by pathogens Not all Lactobacillus spp and not all strains within one Lactobacillus species exhibit all 3 mechanisms Lactobacillus species differ in premenopausal women, ie L crispatus, L jensenii, L iners, L gasseri and possibly L vaginalis, as assessed through cultivation-dependent and cultivation-independent techniques Vaginal lactobacilli have been shown to display a pronounced vaginotropism, and their pili act as ligands for attachment to receptors of vaginal epithelial cells The limited number of Lactobacillus spp found in the human vagina is remarkable, which leads to the possibility that there are host factors that select for specific organisms, that these species have unusual characteristics that allow them to successfully colonize the vagina, or bothHowever, the vaginotropism, does not only apply to this selected group of lactobacilli that stand for a healthy vagina, but also for the bacterial species associated with BV The microbiota detected in the human genital and gut econiche do not appear to grow outside their host and probably are likely to rely on the close contact between parents and their children for transmission, eg mother to neonate transmission of genital microflora, most probably also with gut microflora homogenously distributed over the baby‘s body including skin, the oral cavity, nasopharynx, and feces

Other microbiota

Healthy, normal vaginal microbiota that is dominated by lactobacilli may differ among some ethnic groups Non-pathogenic vaginal species are part of the normal microbiota of some women Several studies have demonstrated that a significant proportion 7–33% of healthy asymptomatic women especially black and Hispanic women lack appreciable numbers of Lactobacillus species in the vagina, and instead have a vaginal microbiota that consist of other lactic acid-producing bacteria, ie species from the genera Atopobium, Leptotrichia, Leuconostoc, Megasphaera, Pediococcus, Streptococcus and Weissella, All ethnic populations have vaginal microflora communities containing lactic acid producing bacteria This implies that not all communities may be equally resilient, so that if the resilience of a vaginal community is low then transitory changes in the structure of these communities may occur more readily in response to disturbances of various kinds, including menses, sexual intercourse, douching and contraceptive practices These differences in the structure and composition of microbial communities may underlie well-known differences in the susceptibility of women in these racial groups to BV and various vaginal infections‖ Though vaginal microflora may be disturbed, and lactic acid is produced by other species, vaginal pH and acid production establish normal vaginal microbiota The pH further decreases during pregnancy

Other vaginal bacterial species

Further information:List of bacterial vaginosis microbiota

Other bacterial species are frequently found in the vagina, such as the Gram positive cocci:Atopobium vaginae, Peptostreptococcus spp, Staphylococcus spp, Streptococcus spp, and Bacteroides spp, Fusobacterium spp, Gardnerella vaginalis, Mobiluncus, Prevotella spp, and Gram-negative enteric organisms, such as Escherichia coli Mycoplasma and Ureaplasma are frequently found in the vagina Some of the obligate and facultative anaerobic bacteria are associated with BV


Main article:Vaginal microbiota in pregnancy

The effect of tampon use on vaginal flora is debated, but application of tampons appears not to significantly modify the balance of bacterial presence Pregnancy alters the microbiota with a reduction in species/genus diversity

Disease prevention

A healthy vaginal microbiome aids in the prevention of bacterial vaginosis, yeast infections and other possible problems by maintaining an acidic pH < 45 that is unfavourable for the growth of common pathogens, such as Gardnerella vaginalis The lactobacilli present in a healthy vaginal microbiome also occupy the ecological niche that would otherwise be available for exploitation by pathogenic organisms However, harmful bacteria or an imbalance in bacteria can lead to infection

Bacterial vaginosis is associated with the presence of Gardnerella vaginalis and Peptostreptococcus anaerobius and a decrease in the number of Lactobacillus species that comprise the healthy vaginal microbiota


Investigations have found that the presence of lacto-bacillus dominated bacteria in the vagina is associated with a lower incidence of sexually transmitted infections

See also

  • Human Microbiome Project
  • Lactic acid bacteria
  • Skin flora
  • Vaginal microbiota in pregnancy


  1. ^ David, M 2006 "Albert und Gustav Döderlein – ein kritischer Blick auf zwei besondere Lebensläufe deutscher Ordinarien" Zentralblatt für Gynäkologie 128 2:56–59 doi:101055/s-2006-921412 ISSN 0044-4197 
  2. ^ a b Vasquez, A; Jakobsson, T; Ahrne, S; Forsum, U; Molin, G 2002 "Vaginal Lactobacillus Flora of Healthy Swedish Women" Journal of Clinical Microbiology 40 8:2746–2749 doi:101128/JCM4082746-27492002 PMC 120688  PMID 12149323 
  3. ^ Witkin, S S; Linhares, I M; Giraldo, P 2007 "Bacterial flora of the female genital tract:Function and immune regulation" Best Practice & Research Clinical Obstetrics & Gynaecology 21 3:347–354 doi:101016/jbpobgyn200612004 PMID 17215167 
  4. ^ Graver M, Wade J 2011 "The role of acidification in the inhibition of Neisseria gonorrhoeae by vaginal lactobacilli during anaerobic growth" Ann Clin Microbiol Antimicrob 10:8 doi:101186/1476-0711-10-8 
  5. ^ Matu M N, Orinda G O, Njagi E N M, Cohen C R, Bukusi E A 2010 "In vitro inhibitory activity of human vaginal lactobacilli against pathogenic bacteria associated with bacterial vaginosis in Kenyan women" Anaerobe 16:210–215 doi:101016/janaerobe200911002 CS1 maint:Multiple names:authors list link
  6. ^ a b Skarin A, Sylwan J 1986 "Vaginal Lactobacilli inhibiting growth of Gardnerella vaginalis, Mobiluncus and other bacterial species cultured from vaginal content of women with bacterial vaginosis" APMIS 94:399–403 doi:101111/j1699-04631986tb03074x 
  7. ^ Strus, M, M Malinowska, and P B Heczko 2002 In vitro antagonistic effect of Lactobacillus on organisms associated with bacterial vaginosis J Reprod Med 47:41–46
  8. ^ Boris S, Barbes C 2000 "Role played by lactobacilli in controlling the population of vaginal pathogens" Microb Infect 2:543–546 doi:101016/s1286-45790000313-0 
  9. ^ a b c Martin R, Suarez J E 2010 "Biosynthesis and degradation of H2O2 by vaginal lactobacilli" Appl Environ Microbiol 76:400–405 
  10. ^ a b c d e f O'Hanlon D, Moench T, Cone R 2011 "In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxide" BMC Infect Dis 11:200 doi:101186/1471-2334-11-200 CS1 maint:Multiple names:authors list link
  11. ^ a b c Aroutcheva A; Gariti D; Simon M; Shott S; Faro J; Simoes J A; Gurguis A; Faro S 2001 "Defense factors of vaginal lactobacilli" Am J Obstet Gynecol 185:375–379 
  12. ^ Linhares I M, Summers P R, Larsen B, Giraldo P C, Witkin S S 2011 "Contemporary perspectives on vaginal pH and lactobacilli" Am J Obstet Gynecol 204:120e1–120e5 doi:101016/jajog201007010 CS1 maint:Multiple names:authors list link
  13. ^ Redondo-Lopez V; Cook R L; Sobel J D 1990 "Emerging role of lactobacilli in the control and maintenance of the vaginal bacterial microflora" Rev Infect Dis 12:856–872 doi:101093/clinids/125856 
  14. ^ Dahiya R S; Speck M L 1968 "Hydrogen peroxide formation by lactobacilli and its effect on Staphylococcus aureus" J Dairy Sci 51:1568–1572 doi:103168/jdss0022-03026887232-7 
  15. ^ Thompson R; Johnson A 1951 "The inhibitory action of saliva on the diphtheria Bacillus:Hydrogen peroxide, the inhibitory agent produced by salivary streptococci" J Infect Dis 88:81–85 doi:101093/infdis/88181 
  16. ^ Wheater D M; Hirsch A; Mattick A T R 1952 "Possible identity of lactobacillin with hydrogen peroxide produced by lactobacilli" Nature 170:623–624 doi:101038/170623a0 
  17. ^ a b c Eschenbach D A; Davick P R; Williams B L; Klebanoff S J; Young-Smith K; Critchlow C M; Holmes K K 1989 "Prevalence of hydrogen peroxide-producing Lactobacillus species in normal women and women with bacterial vaginosis" J Clin Microbiol 27:251–256 
  18. ^ Hillier S L; Krohn M A; Klebanoff S J; Eschenbach D A 1992 "The relationship of hydrogen peroxide-producing lactobacilli to bacterial vaginosis and genital microflora in pregnant women" Obstet Gynecol 79:369–373 doi:101097/00006250-199203000-00008 
  19. ^ Klebanoff SJ 1970 "Peroxidase-mediated antimicrobial activity of rat uterine fluid" Gynecol Invest 1:21–30 doi:101159/000301903 
  20. ^ Baeten J M; Hassan W M; Chohan V; Richardson B A; Mandaliya K; Ndinya-Achola J O; Jaoko W; McClelland R S 2009 "Prospective study of correlates of vaginal Lactobacillus colonisation among high-risk HIV-1 seronegative women" Sex Transm Infect 85:348–353 doi:101136/sti2008035451 
  21. ^ Wilks M, Wiggins R, Whiley A, Hennessy E, Warwick S, Porter H, Corfield A, Millar M 2004 "Identification and H2O2 production of vaginal lactobacilli from pregnant women at high risk of preterm birth and relation with outcome" J Clin Microbiol 42:713–717 doi:101128/jcm422713-7172004 CS1 maint:Multiple names:authors list link
  22. ^ a b c d Verhelst R, Verstraelen H, Claeys G, Verschraegen G, Simaey L Van, De Ganck C, De Backer E, Temmerman M, Vaneechoutte M 2005 "Comparison between Gram stain and culture for the characterization of vaginal microflora:Definition of a distinct grade that resembles grade I microflora and revised categorization of grade I microflora" BMC Microbiol 5:61 CS1 maint:Multiple names:authors list link
  23. ^ a b c De Backer E, Verhelst R, Verstraelen H, Alqumber M A, Burton J P, Tagg J R, Temmerman M, Vaneechoutte M 2007 "Quantitative determination by real-time PCR of four vaginal Lactobacillus species, Gardnerella vaginalis and Atopobium vaginae indicates an inverse relationship between L gasseri and L iners" BMC Microbiol 7:115 doi:101186/1471-2180-7-115 CS1 maint:Multiple names:authors list link
  24. ^ a b Antonio M A; Hawes S E; Hillier S L 1999 "The identification of vaginal Lactobacillus species and the demographic and microbiologic characteristics of women colonized by these species" J Infect Dis 180:1950–1956 doi:101086/315109 PMID 10558952 
  25. ^ Antonio M A D; Rabe L K; Hillier S L 2005 "Colonization of the rectum by Lactobacillus species and decreased risk of bacterial vaginosis" J Infect Dis 192:394–398 doi:101086/430926 
  26. ^ Hawes S E; Hillier S L; Benedetti J; Stevens C E; Koutsky L A; Wolner-Hanssen P L; Holmes K K 1996 "Hydrogen peroxide-producing lactobacilli and acquisition of vaginal infections" J Infect Dis 174:1058–1063 doi:101093/infdis/17451058 
  27. ^ a b c O'Hanlon D E, Lanier B R, Moench T R, Cone R A 2010 "Cervicovaginal fluid and semen block the microbicidal activity of hydrogen peroxide produced by vaginal lactobacilli" BMC Infect Dis 10:120 doi:101186/1471-2334-10-120 CS1 maint:Multiple names:authors list link
  28. ^ Klebanoff S J; Hillier S L; Eschenbach D A; Waltersdorph A M 1991 "Control of the microbial flora of the vagina by H202-generating lactobacilli" J Infect Dis 164:94–100 doi:101093/infdis/164194 
  29. ^ Vallor A C; Antonio M A; Hawes S E; Hillier S L 2001 "Factors associated with acquisition of, or persistent colonization by, vaginal lactobacilli:Role of hydrogen peroxide production" J Infect Dis 184:1431–1436 doi:101086/324445 
  30. ^ a b Ravel, Jacques; Gajer, Pawel; Abdo, Zaid; Schneider, G Maria; Koenig, Sara S K; McCulle, Stacey L; Karlebach, Shara; Gorle, Reshma; Russell, Jennifer; Tacket, Carol O; Brotman, Rebecca M; Davis, Catherine C; Ault, Kevin; Peralta, Ligia; Forney, Larry J 15 March 2011 "Vaginal microbiome of reproductive-age women" Proceedings of the National Academy of Sciences 108 Supplement 1:4680–4687 doi:101073/pnas1002611107 ISSN 0027-8424 PMC 3063603  PMID 20534435 Retrieved 27 May 2016 
  31. ^ a b c d e Zhou X; Bent S J; Schneider M G; Davis C C; Islam M R; Forney L J 2004 "Characterization of vaginal microbial communities in adult healthy women using cultivation-independent methods" Microbiology 150:2565–2573 doi:101099/mic026905-0 
  32. ^ a b Danielsson D; Teigen P K; Moi H 2011 "The genital econiche:Focus on microbiota and bacterial vaginosis" Ann N Y Acad Sci 1230:48–58 doi:101111/j1749-6632201106041x PMID 21824165 
  33. ^ Dominguez-Bello M G; Costello E K; Contreras M; Magris M; Hidalgo G; Fierer N; Knight R 2010 "Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns" Proc Natl Acad Sci USA 107:11971–11975 doi:101073/pnas1002601107 PMC 2900693  PMID 20566857 
  34. ^ Lopes, Santos Santiago G, Cools P, Verstraelen H, Trog M, Missine G, Aila N El, Verhelst R, Tency I, Claeys G, Temmerman M, Vaneechoutte M 2011 "Longitudinal study of the dynamics of vaginal microflora during two consecutive menstrual cycles" PLOS ONE 6:e28180 doi:101371/journalpone0028180 PMC 3227645  PMID 22140538 CS1 maint:Multiple names:authors list link
  35. ^ a b c d Zhou X; Brown C J; Abdo Z; Davis C C; Hansmann M A; Joyce P; Foster J A; Forney L J 2007 "Differences in the composition of vaginal microbial communities found in healthy Caucasian and black women" ISME J 1:121–133 doi:101038/ismej200712 
  36. ^ a b Hummelen R; Fernandes A D; Macklaim J M; Dickson R J; Changalucha J; Gloor G B; Reid G 2010 "Deep sequencing of the vaginal microbiota of women with HIV" PLOS ONE 5:e12078 doi:101371/journalpone0012078 
  37. ^ Martin J A; Hamilton B E; Sutton P D; Ventura S J; Mathews T J; Kirmeyer S; Osterman M J 2010 "Births:Final data for 2007" National vital statistics reports 58:1–85 
  38. ^ Ness R B; Hillier S; Richter H E; Soper D E; Stamm C; Bass D C; Sweet R L; Rice P 2003 "Can known risk factors explain racial differences in the occurrence of bacterial vaginosis" J Natl Med Assoc 95:201–212 
  39. ^ Mirmonsef P; Gilbert D; Veazey R S; Wang J; Kendrick S R; Spear G T 2012 "A comparison of lower genital tract glycogen and lactic acid levels in women and macaques:Implications for HIV and SIV susceptibility" AIDS Res Hum Retroviruses 28:76–81 doi:101089/aid20110071 
  40. ^ Hillier S L; Nugent R P; Eschenbach D A; Krohn M A; Gibbs R S; Martin D H; Cotch M F; Edelman R; Pastorek J G; Rao A V; McNellis D; Regan J A; Carey J C; Klebanoff M A 1995 "Association between bacterial vaginosis and preterm delivery of a lowbirth-weight infant" N Engl J Med 333:1737–1742 doi:101056/nejm199512283332604 PMID 7491137 
  41. ^ a b Clark, Natalie; Tal, Reshef; Sharma, Harsha; Segars, James 2014 "Microbiota and Pelvic Inflammatory Disease" Seminars in Reproductive Medicine 32 01:043–049 doi:101055/s-0033-1361822 ISSN 1526-8004 PMC 4148456  PMID 24390920 
  42. ^ "Bacterial Vaginosis BV:Condition Information" National Institute of Child Health and Human Development 2013-05-21 Retrieved 3 March 2015 
  43. ^ Nardis, C; Mastromarino, P; Mosca, L September 2013 "Vaginal microbiota and viral sexually transmitted diseases" Annali di Igiene 25 5:443–56 doi:107416/ai20131946 PMID 24048183 
  44. ^ "What are the symptoms of bacterial vaginosis" National Institute of Child Health and Human Development 2013-05-21 Retrieved 22 May 2016 
  45. ^ Ravel, J; et al 2010 "Colloquium Paper:Vaginal microbiome of reproductive-age women" Proceedings of the National Academy of Sciences 108 Supplement_1:4680–4687 doi:101073/pnas1002611107 PMC 3063603  PMID 20534435 CS1 maint:Explicit use of et al link
  46. ^ Nunn, Kenetta L; Wang, Ying-Ying; Harit, Dimple; Humphrys, Michael S; Ma, Bing; Cone, Richard; Ravel, Jacques; Lai, Samuel K 2015-10-06 "Enhanced Trapping of HIV-1 by Human Cervicovaginal Mucus Is Associated with Lactobacillus crispatus-Dominant Microbiota" mBio 6 5:e01084–15 doi:101128/mBio01084-15 PMC 4611035  PMID 26443453 
  47. ^ Anderson, Deborah J; Marathe, Jai; Pudney, Jeffrey 2014-06-01 "The Structure of the Human Vaginal Stratum Corneum and its Role in Immune Defense" American Journal of Reproductive Immunology 71 6:618–623 doi:101111/aji12230 ISSN 1600-0897 

External links

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