Mon . 19 May 2019

Tyrosine-protein kinase CSK

tyrosine protein kinase csk vs srh, tyrosine protein kinase cska
1BYG, 1CSK, 3D7T, 3D7U, 3EAC, 3EAZ

Identifiers Aliases CSK, Src, c-src tyrosine kinase, CSK/Src, non-receptor tyrosine kinase, C-terminal Src kinase External IDs OMIM: 190090 MGI: 88537 HomoloGene: 55818 GeneCards: CSK
Gene location Human
Chr Chromosome 15 human
Band 15q241 Start 74,782,057 bp
End 74,803,198 bp
RNA expression pattern
More reference expression data
Orthologs Species Human Mouse Entrez
RefSeq mRNA



RefSeq protein



Location UCSC Chr 15: 7478 – 748 Mb Chr 9: 5763 – 5765 Mb PubMed search Wikidata
^ "Mouse PubMed Reference:" 
  • ^ "Entrez Gene: C-src tyrosine kinase" Retrieved 2013-07-11 
  • ^ a b Bergman M, Mustelin T, Oetken C, Partanen J, Flint NA, Amrein KE, Autero M, Burn P, Alitalo K Aug 1992 "The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity" The EMBO Journal 11 8: 2919–24 PMC 556773  PMID 1639064 
  • ^ a b Sun G, Budde RJ Sep 1997 "Expression, purification, and initial characterization of human Yes protein tyrosine kinase from a bacterial expression system" Archives of Biochemistry and Biophysics 345 1: 135–42 doi:101006/abbi19970236 PMID 9281320 
  • ^ Nada S, Okada M, MacAuley A, Cooper JA, Nakagawa H May 1991 "Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src" Nature 351 6321: 69–72 Bibcode:1991Natur35169N doi:101038/351069a0 PMID 1709258 
  • ^ Nada S, Yagi T, Takeda H, Tokunaga T, Nakagawa H, Ikawa Y, Okada M, Aizawa S Jun 1993 "Constitutive activation of Src family kinases in mouse embryos that lack Csk" Cell 73 6: 1125–35 doi:101016/0092-86749390642-4 PMID 8513497 
  • ^ Chong YP, Chan AS, Chan KC, Williamson NA, Lerner EC, Smithgall TE, Bjorge JD, Fujita DJ, Purcell AW, Scholz G, Mulhern TD, Cheng HC Nov 2006 "C-terminal Src kinase-homologous kinase CHK, a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases" The Journal of Biological Chemistry 281 44: 32988–99 doi:101074/jbcM602951200 PMID 16959780 
  • ^ Chong YP, Mulhern TD, Cheng HC Sep 2005 "C-terminal Src kinase CSK and CSK-homologous kinase CHK--endogenous negative regulators of Src-family protein kinases" Growth Factors 23 3: 233–44 doi:101080/08977190500178877 PMID 16243715 
  • ^ a b Universal protein resource accession number P41240 for "Tyrosine-protein kinase CSK" at UniProt
  • ^ Bräuninger A, Holtrich U, Strebhardt K, Rübsamen-Waigmann H Jan 1992 "Isolation and characterization of a human gene that encodes a new subclass of protein tyrosine kinases" Gene 110 2: 205–11 doi:101016/0378-11199290649-a PMID 1371489 
  • ^ a b Joukov V, Vihinen M, Vainikka S, Sowadski JM, Alitalo K, Bergman M Mar 1997 "Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure" The Biochemical Journal 322 3: 927–35 doi:101042/bj3220927 PMC 1218276  PMID 9148770 
  • ^ Vang T, Torgersen KM, Sundvold V, Saxena M, Levy FO, Skålhegg BS, Hansson V, Mustelin T, Taskén K Feb 2001 "Activation of the COOH-terminal Src kinase Csk by cAMP-dependent protein kinase inhibits signaling through the T cell receptor" The Journal of Experimental Medicine 193 4: 497–507 doi:101084/jem1934497 PMC 2195911  PMID 11181701 
  • ^ Fiorillo E, Orrú V, Stanford SM, Liu Y, Salek M, Rapini N, Schenone AD, Saccucci P, Delogu LG, Angelini F, Manca Bitti ML, Schmedt C, Chan AC, Acuto O, Bottini N Aug 2010 "Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue" The Journal of Biological Chemistry 285 34: 26506–18 doi:101074/jbcM110111104 PMC 2924087  PMID 20538612 
  • External links

    • CSK tyrosine-protein kinase at the US National Library of Medicine Medical Subject Headings MeSH
    • Molecular and Cellular Biology portal

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