Triturationtrituration, trituration meaning
Trituration is the name of several different methods used to process materials In one sense, it is a form of comminution reducing the particle size of a substance In another sense, it is the production of a homogeneous material by mixing component materials thoroughly For example, a dental amalgam is formed by combining particles of an alloy with mercury
In organic chemistry, trituration is a process used to purify crude chemical compounds containing soluble impurities A solvent is chosen in which the desired product is insoluble and the undesired by-products are very soluble or vice versa The crude material is washed with the solvent and filtered, leaving the purified product in solid form and any impurities in solution
In pharmacology, trituration can also refer to the process of grinding one compound into another to dilute one of the ingredients, add volume for processing and handling, or to mask undesirable qualities For example, the amount of hormone in a dose of Levonorgestrel formulated as a progestogen-only contraceptive is only 30µg, which is far too small to handle In a typical product, the drug is triturated with c 1700 times its mass of sugar before being compressed and coated to produce the final tablet
In juicing, a triturating juicer is a style of juicer used to break down fresh produce into juice and fiber
In homeopathy, a trituration is a solution in lactose of a substance that is not water-soluble
- ^ "Norgeston" electronic Medicines Compendium 2 Qualitative and quantitative composition Retrieved 2013-08-22
- ^ "Guidelines for Manufacturing Homeopathic Medicines" PDF Homœopathic Pharmacopœia Convention of the United States p 38
- Remington's Pharmaceutical Sciences 17th ed Mack Publishing Company 1985 p 1599 ISBN 0-912734-03-5
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