In the field of molecular biology, transrepression is a process whereby one protein represses ie, inhibits the activity of a second protein through a protein-protein interaction Since this repression occurs between two different protein molecules intermolecular, it is referred to as a trans-acting process
The protein that is repressed is usually a transcription factor whose function is to up-regulate ie, increase the rate of gene transcription Hence the net result of transrepression is down regulation of gene transcription
An example of transrepression is the ability of the glucocorticoid receptor to inhibit the transcriptional promoting activity of the AP-1 and NF-κB transcription factors In addition to transactivation, transrepression is an important pathway for the anti-inflammatory effects of glucocorticoids Other nuclear receptors such as LXR and PPAR have been demonstrated to also have the ability to transrepress the activity of other proteins
- Selective glucocorticoid receptor agonist
- ^ Lucibello FC, Slater EP, Jooss KU, Beato M, Müller R September 1990 "Mutual transrepression of Fos and the glucocorticoid receptor: involvement of a functional domain in Fos which is absent in FosB" EMBO J 9 9: 2827–34 PMC 551994 PMID 2118106
- ^ Lin, Cw; Nakane, M; Stashko, M; Falls, D; Kuk, J; Miller, L; Huang, R; Tyree, C; Miner, Jn; Rosen, J; Kym, Pr; Coghlan, Mj; Carter, G; Lane, Bc Aug 2002 "trans-Activation and repression properties of the novel nonsteroid glucocorticoid receptor ligand 2,5-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5-1-methylcyclohexen-3-y1-1H-1benzopyrano3,4-fquinoline A276575 and its four stereoisomers" Free full text Molecular Pharmacology 62 2: 297–303 doi:101124/mol622297 ISSN 0026-895X PMID 12130681
- ^ Pascual G, Glass CK October 2006 "Nuclear receptors versus inflammation: mechanisms of transrepression" Trends Endocrinol Metab 17 8: 321–7 doi:101016/jtem200608005 PMID 16942889
- ^ Newton R, Holden NS October 2007 "Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor" Mol Pharmacol 72 4: 799–809 doi:101124/mol107038794 PMID 17622575
- ^ Ghisletti S, Huang W, Ogawa S, Pascual G, Lin ME, Willson TM, Rosenfeld MG, Glass CK January 2007 "Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARγ" Mol Cell 25 1: 57–70 doi:101016/jmolcel200611022 PMC 1850387 PMID 17218271
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