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Transforming growth factor

transforming growth factor beta, transforming growth factor receptor
Transforming growth factor sometimes referred to as Tumor growth factor, or TGF is used to describe two classes of polypeptide growth factors, TGFα and TGFβ

The name "Transforming Growth Factor" is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different receptor mechanisms Furthermore, they do not always induce cellular transformation, and are not the only growth factors that induce cellular transformation

Contents

  • 1 Types
  • 2 Function
  • 3 See also
  • 4 References
  • 5 External links

Typesedit

  • TGFα is upregulated in some human cancers It is produced in macrophages, brain cells, and keratinocytes, and induces epithelial development
  • TGFβ exists in three known subtypes in humans, TGFβ1, TGFβ2, and TGFβ3 These are upregulated in Marfan's syndrome12 and some human cancers, and play crucial roles in tissue regeneration, cell differentiation, embryonic development, and regulation of the immune system Isoforms of transforming growth factor-beta TGF-β1 are also thought to be involved in the pathogenesis of pre-eclampsia TGFβ receptors are single pass serine/threonine kinase receptors

Functionedit

These proteins were originally characterized by their capacity to induce oncogenic transformation in a specific cell culture system, rat kidney fibroblasts Application of the transforming growth factors to normal rat kidney fibroblasts induces the cultured cells to proliferate and overgrow, no longer subject to the normal inhibition caused by contact between cells

See alsoedit

  • Bone morphogenetic protein
  • TGF beta signaling pathway
  • Tubuloglomerular feedback

Referencesedit

  1. ^ Matt, P; Schoenhoff, F; Habashi, J; Holm, T; Van Erp, C; Loch, D; Carlson, OD; Griswold, BF; Fu, Q; De Backer, J; Loeys, B; Huso, DL; McDonnell, NB; Van Eyk, JE; Dietz, HC Aug 2009 "Circulating transforming growth factor- in Marfan syndrome" Circulation 120 6: 526–32 PMC 2779568  PMID 19635970 doi:101161/CIRCULATIONAHA108841981 
  2. ^ Inhibiting TGF to help Marfan

External linksedit

  • Tumor growth factor TGF citations
  • Hoffmann, R; Valencia, A 2004 "A gene network for navigating the literature" Nature Genetics 36: 664 PMID 15226743 doi:101038/ng0704-664 
  • Transforming Growth Factors at the US National Library of Medicine Medical Subject Headings MeSH


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Transforming growth factor Information about

Transforming growth factor


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    Transforming growth factor beatiful post thanks!

    29.10.2014


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