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transcortin lab test, transcortin
2VDX, 2VDY, 4BB2, 4C41, 4C49

Identifiers Aliases SERPINA6, CBG, serpin family A member 6 External IDs OMIM: 122500 MGI: 88278 HomoloGene: 20417 GeneCards: SERPINA6
Gene location Human
Chr Chromosome 14 human
Band 14q3213 Start 94,304,248 bp
End 94,323,394 bp
RNA expression pattern
More reference expression data
Orthologs Species Human Mouse Entrez
RefSeq mRNA



RefSeq protein



Location UCSC Chr 14: 943 – 9432 Mb Chr 12: 10365 – 10366 Mb PubMed search Wikidata
  • ^ a b c ENSG00000170099 GRCh38: Ensembl release 89: ENSG00000277405, ENSG00000170099 - Ensembl, May 2017
  • ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060807 - Ensembl, May 2017
  • ^ "Human PubMed Reference:" 
  • ^ "Mouse PubMed Reference:" 
  • ^ Hammond GL, Smith CL, Goping IS, Underhill DA, Harley MJ, Reventos J, Musto NA, Gunsalus GL, Bardin CW August 1987 "Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors" Proc Natl Acad Sci U S A 84 15: 5153–7 doi:101073/pnas84155153 PMC 298812  PMID 3299377 
  • ^ Byth BC, Billingsley GD, Cox DW July 1994 "Physical and genetic mapping of the serpin gene cluster at 14q321: allelic association and a unique haplotype associated with alpha 1-antitrypsin deficiency" Am J Hum Genet 55 1: 126–33 PMC 1918218  PMID 7912884 
  • ^ a b "Entrez Gene: SERPINA6 serpin peptidase inhibitor, clade A alpha-1 antiproteinase, antitrypsin, member 6" 
  • ^ a b c E Edward Bittar; Neville Bittar 1997 Molecular and Cellular Endocrinology Elsevier p 238 ISBN 978-1-55938-815-3 Retrieved 23 August 2012 
  • ^ Principles and Practice of Endocrinology and Metabolism Lippincott Williams & Wilkins 24 April 2001 p 712 ISBN 978-0-7817-1750-2 Retrieved 23 August 2012 
  • ^ Negi 2009 Introduction To Endocrinology PHI Learning Pvt Ltd p 268 ISBN 978-81-203-3850-0 Retrieved 23 August 2012 
  • ^ Dunn JF, Nisula BC, Rodbard D July 1981 "Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma" The Journal of Clinical Endocrinology and Metabolism 53 1: 58–68 doi:101210/jcem-53-1-58 PMID 7195404 
  • ^ Musa BU, Seal US, Doe RP September 1965 "Elevation of certain plasma proteins in man following estrogen administration: a dose-response relationship" J Clin Endocrinol Metab 25 9: 1163–6 doi:101210/jcem-25-9-1163 PMID 4284083 
  • ^ Torpy DJ, Lundgren BA, Ho JT, Lewis JG, Scott HS, Mericq V January 2012 "CBG Santiago: a novel CBG mutation" J Clin Endocrinol Metab 97 1: E151–5 doi:101210/jc2011-2022 PMID 22013108 
  • ^ Rosen MI, Shnider SM, Levinson G, Hughes 2002 Shnider and Levinson's anesthesia for obstetrics Hagerstwon, MD: Lippincott Williams & Wilkins p 13 ISBN 0-683-30665-0 CS1 maint: Multiple names: authors list link
  • Further reading

    • Rosner W, Beers PC, Awan T, Khan MS 1976 "Identification of corticosteroid-binding globulin in human milk: measurement with a filter disk assay" J Clin Endocrinol Metab 42 6: 1064–73 doi:101210/jcem-42-6-1064 PMID 932172 
    • Smith CL, Power SG, Hammond GL 1992 "A Leu----His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol" J Steroid Biochem Mol Biol 42 7: 671–6 doi:101016/0960-07609290107-T PMID 1504007 
    • Brotherton J 1990 "Cortisol and transcortin in human seminal plasma and amniotic fluid as estimated by modern specific assays" Andrologia 22 3: 197–204 doi:101111/j1439-02721990tb01966x PMID 2240617 
    • Seralini GE, Bérubé D, Gagné R, Hammond GL 1991 "The human corticosteroid binding globulin gene is located on chromosome 14q31-q321 near two other serine protease inhibitor genes" Hum Genet 86 1: 73–5 doi:101007/bf00205177 PMID 2253941 
    • Underhill DA, Hammond GL 1990 "Organization of the human corticosteroid binding globulin gene and analysis of its 5'-flanking region" Mol Endocrinol 3 9: 1448–54 doi:101210/mend-3-9-1448 PMID 2608068 
    • Loric S, Egloff M, Domingo M, et al 1990 "Immunochemical characterization of corticosteroid-binding globulin in human bronchoalveolar fluid" Clin Chim Acta 186 1: 19–23 doi:101016/0009-89818990198-8 PMID 2612005 
    • Heubner A, Belovsky O, Müller W, et al 1987 "Application of liquid-liquid partition chromatography in the simultaneous purification of sex-hormone-binding globulin and corticosteroid-binding globulin" J Chromatogr 397: 419–34 doi:101016/S0021-96730185027-5 PMID 2821037 
    • Kato EA, Hsu BR, Kuhn RW 1988 "Comparative structural analyses of corticosteroid binding globulin" J Steroid Biochem 29 2: 213–20 doi:101016/0022-47318890268-3 PMID 3347061 
    • Bardin CW, Gunsalus GL, Musto NA, et al 1988 "Corticosteroid binding globulin, testosterone-estradiol binding globulin, and androgen binding protein belong to protein families distinct from steroid receptors" J Steroid Biochem 30 1-6: 131–9 doi:101016/0022-47318890085-4 PMID 3386241 
    • Hammond GL, Langley MS 1986 "Identification and measurement of sex hormone binding globulin SHBG and corticosteroid binding globulin CBG in human saliva" Acta Endocrinol 112 4: 603–8 doi:101530/acta01120603 PMID 3751467 
    • Agrimonti F, Frairia R, Fornaro D, et al 1983 "Circadian and circaseptan rhythmicities in corticosteroid-binding globulin CBG binding activity of human milk" Chronobiologia 9 3: 281–90 PMID 7172869 
    • Misao R, Hori M, Ichigo S, et al 1995 "Levels of sex hormone-binding globulin SHBG and corticosteroid-binding globulin CBG messenger ribonucleic acid mRNAs in ovarian endometriosis" Reprod Nutr Dev 35 2: 155–65 doi:101051/rnd:19950204 PMID 7734053 
    • Misao R, Hori M, Ichigo S, et al 1995 "Corticosteroid-binding globulin mRNA levels in human uterine endometrium" Steroids 59 10: 603–7 doi:101016/0039-128X9490055-8 PMID 7878688 
    • Maruyama K, Sugano S 1994 "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides" Gene 138 1-2: 171–4 doi:101016/0378-11199490802-8 PMID 8125298 
    • Avvakumov GV, Hammond GL 1994 "Glycosylation of human corticosteroid-binding globulin Differential processing and significance of carbohydrate chains at individual sites" Biochemistry 33 19: 5759–65 doi:101021/bi00185a012 PMID 8180202 
    • Van Baelen H, Power SG, Hammond GL 1993 "Decreased cortisol-binding affinity of transcortin Leuven is associated with an amino acid substitution at residue-93" Steroids 58 6: 275–7 doi:101016/0039-128X9390072-U PMID 8212073 
    • Misao R, Nakanishi Y, Fujimoto J, et al 1996 "Expression of corticosteroid-binding globulin mRNA in human uterine endometrial cancers" Steroids 60 10: 720–4 doi:101016/0039-128X9500106-Z PMID 8539782 
    • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al 1997 "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library" Gene 200 1-2: 149–56 doi:101016/S0378-11199700411-3 PMID 9373149 

    External links

    • Transcortin at the US National Library of Medicine Medical Subject Headings MeSH
    • The MEROPS online database for peptidases and their inhibitors: I04954
    • SERPINA6 protein, human at the US National Library of Medicine Medical Subject Headings MeSH

    transcortin, transcortin blood test, transcortin elevation, transcortin lab test, transcortin test, transcortina, transcortine élevée

    Transcortin Information about


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