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Timeline of myocardial infarction pathology

timeline of myocardial infarction pathology outlines, timeline of myocardial infarction pathology table
This table gives an overview of the pathology seen in myocardial infarction by time after obstruction

Time Gross examination Histopathology
light microscopy
0 - 05 hours None None
05 – 4 hours None
  • Glycogen Depletion, as seen with a PAS Stain
  • Possibly waviness of fibers at border
4 – 12 hours
  • Sometimes dark mottling
  • Initiation of coagulation necrosis
  • Edema
  • Hemorrhage
12 – 24 hours
  • Dark mottling
  • Ongoing coagulation necrosis
  • Karyopyknosis
  • Hypereosinophilia of myocytes
  • Contraction band necrosis in margins
  • Beginning of neutrophil infiltration
1 – 3 days
  • Infarct center becomes yellow-tan
  • Continued coagulation necrosis
  • Loss of nuclei and striations
  • Increased infiltration of neutrophils to interstitium
3 – 7 days
  • Hyperemia at border
  • Softening yellow-tan center
  • Beginning of disintegration of dead muscle fibers
  • Apoptosis of neutrophils
  • Beginning of macrophage removal of dead cells at border
7 – 10 days
  • Maximally soft and yellow-tan
  • Red-tan margins
  • Increased phagocytosis of dead cells at border
  • Beginning of granulation tissue formation at margins
10 – 14 days
  • Red-gray and depressed borders
  • Mature granulation tissue with type I collagen
2 – 8 weeks
  • Gray-white granulation tissue
  • Increased collagen deposition
  • Decreased cellularity
More than 2 months Completed scarring Dense collagenous scar formed
If not else specified in boxes, then reference is nr

Notes

  1. ^ a b For the first ~30 minutes no change at all can be seen by gross examination or by light microscopy in histopathology However, in electron microscopy relaxed myofibrils, as well as glycogen loss and mitochondrial swelling can be observered
  2. ^ It is often possible, however, to highlight the area of necrosis that first becomes apparent after 2 to 3 hours by immersion of tissue slices in a solution of triphenyltetrazolium chloride This dye imparts a brick-red color to intact, noninfarcted myocardium where the dehydrogenase activity is preserved Because dehydrogenases are depleted in the area of ischemic necrosis ie, they leak out through the damaged cell membranes, an infarcted area is revealed as an unstained pale zone Instead of a triphenyltetrazolium chloride dye, a LDH lactate dehydrogenase dye can also be used to visualize an area of necrosis
  3. ^ a b Once scarring is completed, there is yet no common method of discerning the actual age of the infarct, since eg a scar that is four months old looks identical to a scar that is ten years old

References

  1. ^ Bishop JE, Greenbaum R, Gibson DG, Yacoub M, Laurent GJ Enhanced deposition of predominantly type I collagen in myocardial disease J Mol Cell Cardiol 1990;22:1157–1165
  2. ^ Table 11-2 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K; Fausto, Nelson Robbins Basic Pathology Philadelphia: Saunders ISBN 1-4160-2973-7  8th edition

timeline of myocardial infarction pathology outlines, timeline of myocardial infarction pathology table, timeline of myocardial infarction pathology timeline


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Timeline of myocardial infarction pathology


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    Timeline of myocardial infarction pathology beatiful post thanks!

    29.10.2014


Timeline of myocardial infarction pathology
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