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Thyroid peroxidase

thyroid peroxidase antibodies, thyroid peroxidase levels
Thyroid peroxidase, also called thyroperoxidase TPO or iodide peroxidase, is an enzyme expressed mainly in the thyroid where it is secreted into colloid Thyroid peroxidase oxidizes iodide ions to form iodine atoms for addition onto tyrosine residues on thyroglobulin for the production of thyroxine T4 or triiodothyronine T3, the thyroid hormones In humans, thyroperoxidase is encoded by the TPO gene

Contents

  • 1 Catalyzed reaction
  • 2 Function
  • 3 Stimulation and inhibition
  • 4 Clinical significance
  • 5 Diagnostic use
  • 6 References
  • 7 External links

Catalyzed reaction

+ I− + H+ + H2O2 ⇒ + 2 H2O

Iodide is oxidized to iodine radical which immediately reacts with tyrosine

+ I− + H+ + H2O2 ⇒ + 2 H2O

The second iodine atom is added in similar manner to the reaction intermediate 3-iodotyrosine

Function

Thyroid hormone synthesis, with thyroid peroxidase performing the oxidation step seen at center-left in the image

Inorganic iodine enters the body primarily as iodide, I− After entering the thyroid follicle or thyroid follicular cell via a Na+/I− symporter NIS on the basolateral side, iodide is shuttled across the apical membrane into the colloid via pendrin, after which thyroid peroxidase oxidizes iodide to atomic iodine I or iodinium I+ The "organification of iodine," the incorporation of iodine into thyroglobulin for the production of thyroid hormone, is nonspecific; that is, there is no TPO-bound intermediate, but iodination occurs via reactive iodine species released from TPO The chemical reactions catalyzed by thyroid peroxidase occur on the outer apical membrane surface and are mediated by hydrogen peroxide

Stimulation and inhibition

TPO is stimulated by TSH, which upregulates gene expression

TPO is inhibited by the thioamide drugs, such as propylthiouracil and methimazole In laboratory rats with insufficient iodine intake, genistein has demonstrated inhibition of TPO

Clinical significance

Thyroid peroxidase is a frequent epitope of autoantibodies in autoimmune thyroid disease, with such antibodies being called anti-thyroid peroxidase antibodies anti-TPO antibodies This is most commonly associated with Hashimoto's thyroiditis Thus, an antibody titer can be used to assess disease activity in patients that have developed such antibodies

Diagnostic use

In diagnostic immunohistochemistry, the expression of thyroid peroxidase TPO is lost in papillary thyroid carcinoma

References

  1. ^ Ruf J, Carayon P Jan 2006 "Structural and functional aspects of thyroid peroxidase" Archives of Biochemistry and Biophysics 445 2: 269–77 doi:101016/jabb200506023 PMID 16098474 
  2. ^ Kimura S, Kotani T, McBride OW, Umeki K, Hirai K, Nakayama T, Ohtaki S Aug 1987 "Human thyroid peroxidase: complete cDNA and protein sequence, chromosome mapping, and identification of two alternately spliced mRNAs" Proceedings of the National Academy of Sciences of the United States of America 84 16: 5555–9 doi:101073/pnas84165555 PMC 298901  PMID 3475693 
  3. ^ Walter F, PhD Boron 2003 Medical Physiology: A Cellular And Molecular Approaoch Elsevier/Saunders p 1300 ISBN 1-4160-2328-3 
  4. ^ Kessler J, Obinger C, Eales G Jul 2008 "Factors influencing the study of peroxidase-generated iodine species and implications for thyroglobulin synthesis" Thyroid 18 7: 769–74 doi:101089/thy20070310 PMID 18631006 
  5. ^ Nagasaka A, Hidaka H Jul 1976 "Effect of antithyroid agents 6-propyl-2-thiouracil and 1-mehtyl-2-mercaptoimidazole on human thyroid iodine peroxidase" The Journal of Clinical Endocrinology and Metabolism 43 1: 152–8 doi:101210/jcem-43-1-152 PMID 947933 
  6. ^ Doerge DR, Sheehan DM Jun 2002 "Goitrogenic and estrogenic activity of soy isoflavones" Environmental Health Perspectives 110 Suppl 3: 349–53 doi:101289/ehp02110s3349 PMC 1241182  PMID 12060828 
  7. ^ McLachlan SM, Rapoport B 2000 "Autoimmune response to the thyroid in humans: thyroid peroxidase--the common autoantigenic denominator" International Reviews of Immunology 19 6: 587–618 doi:103109/08830180009088514 PMID 11129117 
  8. ^ Chardès T, Chapal N, Bresson D, Bès C, Giudicelli V, Lefranc MP, Péraldi-Roux S Jun 2002 "The human anti-thyroid peroxidase autoantibody repertoire in Graves' and Hashimoto's autoimmune thyroid diseases" Immunogenetics 54 3: 141–57 doi:101007/s00251-002-0453-9 PMID 12073143 
  9. ^ Tanaka T, Umeki K, Yamamoto I, Sugiyama S, Noguchi S, Ohtaki S May 1996 "Immunohistochemical loss of thyroid peroxidase in papillary thyroid carcinoma: strong suppression of peroxidase gene expression" The Journal of Pathology 179 1: 89–94 doi:101002/SICI1096-9896199605179:1<89::AID-PATH546>30CO;2-R PMID 8691351 

External links

  • Thyroid Peroxidase at the US National Library of Medicine Medical Subject Headings MeSH
  • Molecular and Cellular Biology portal

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Thyroid peroxidase


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    Thyroid peroxidase beatiful post thanks!

    29.10.2014


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