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Thiouracil

thiouracil drug, thiouracil
Thiouracil refers both to a specific molecule consisting of a sulfated uracil, and a family of molecules based upon that structure

Medical use

The substance is a historically relevant anti-thyroid preparation Astwood EB used it in 1943 as therapy of Graves' disease for the first time It remains in use

Thiouracil inhibits thyroid activity by blocking the enzyme thyroid peroxidase Its use in recent times has been replaced by advent of more potent and safer antithyroid drugs

References

  1. ^ Gerabek, W 2005 Enzyklopädie Medizingeschichte p 152 ISBN 9783110157147 
  2. ^ Nagasaka, A; Hidaka, H 1976 "Effect of Antithyroid Agents 6-Propyl-2-Thiouracil and l-Methyl-2-Mercaptoimidazole on Human Thyroid Iodide Peroxidase" Journal of Clinical Endocrinology & Metabolism 43 1:152–8 doi:101210/jcem-43-1-152 PMID 947933 


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Thiouracil Information about

Thiouracil


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    29.10.2014


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