Tazobactamtazobactam piperacillin, tazobactam
Tazobactam is a pharmaceutical drug that inhibits the action of bacterial β-lactamases, especially those belonging to the SHV-1 and TEM groups It is commonly used as its sodium salt, tazobactam sodium
Tazobactam is combined with the extended spectrum β-lactam antibiotic piperacillin in the drug piperacillin/tazobactam, used in infections due Pseudomonas aeruginosa Tazobactam broadens the spectrum of piperacillin by making it effective against organisms that express β-lactamase and would normally degrade piperacillin
Tazobactam is a heavily modified penicillin and a sulfone
Tazobactam was patented in 1982 and came into medical use in 1992
- ^ Yang Y, Rasmussen BA, Shlaes DM 1999 "Class A beta-lactamases—enzyme-inhibitor interactions and resistance" Pharmacol Ther 83: 141–151 doi:101016/S0163-72589900027-3
- ^ Fischer, Janos; Ganellin, C Robin 2006 Analogue-based Drug Discovery John Wiley & Sons p 490 ISBN 9783527607495
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