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Tazobactam

tazobactam piperacillin, tazobactam
Tazobactam is a pharmaceutical drug that inhibits the action of bacterial β-lactamases, especially those belonging to the SHV-1 and TEM groups It is commonly used as its sodium salt, tazobactam sodium

Tazobactam is combined with the extended spectrum β-lactam antibiotic piperacillin in the drug piperacillin/tazobactam, used in infections due Pseudomonas aeruginosa Tazobactam broadens the spectrum of piperacillin by making it effective against organisms that express β-lactamase and would normally degrade piperacillin

Tazobactam is a heavily modified penicillin and a sulfone

Tazobactam was patented in 1982 and came into medical use in 1992

See also

  • Ceftolozane
  • Sulbactam
  • Clavulanate

References

  1. ^ Yang Y, Rasmussen BA, Shlaes DM 1999 "Class A beta-lactamases—enzyme-inhibitor interactions and resistance" Pharmacol Ther 83: 141–151 doi:101016/S0163-72589900027-3 
  2. ^ Fischer, Janos; Ganellin, C Robin 2006 Analogue-based Drug Discovery John Wiley & Sons p 490 ISBN 9783527607495 


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Tazobactam Information about

Tazobactam


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    Tazobactam beatiful post thanks!

    29.10.2014


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