Fri . 20 Jul 2020
TR | RU | UK | KK | BE |

T helper cell

t helper cells, t helper cell markers
The T helper cells Th cells are a type of T cell that play an important role in the immune system, particularly in the adaptive immune system They help the activity of other immune cells by releasing T cell cytokines These cells help suppress or regulate immune responses They are essential in B cell antibody class switching, in the activation and growth of cytotoxic T cells, and in maximizing bactericidal activity of phagocytes such as macrophages

Mature Th cells express the surface protein CD4 and are referred to as CD4+ T cells Such CD4+ T cells are generally treated as having a pre-defined role as helper T cells within the immune system For example, when an antigen-presenting cell expresses an antigen on MHC class II, a CD4+ cell will aid those cells through a combination of cell to cell interactions eg CD40 protein and CD40L and through cytokines

CD154, also called CD40 ligand or CD40L, is a cell surface protein that mediates T cell helper function in a contact-dependent process1 and is a member of the TNF superfamily of molecules It binds to CD40 on antigen-presenting cells APC, which leads to many effects depending on the target cell type CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells TFH cells2 On TFH cells, CD154 promotes B cell maturation and function by engaging CD40 on the B cell surface and therefore facilitating cell-cell communication3 A defect in this gene results in an inability to undergo immunoglobulin class switching and is associated with hyper IgM syndrome4 Absence of CD154 also stops the formation of germinal centers and therefore prohibiting antibody affinity maturation, an important process in the adaptive immune system

The importance of helper T cells can be seen from HIV, a virus that primarily infects CD4+ T cells In the advanced stages of HIV infection, loss of functional CD4+ T cells leads to the symptomatic stage of infection known as the acquired immunodeficiency syndrome AIDS When the HIV virus is detected early in blood or other bodily fluids, continuous therapy can delay the time at which this fall happens Therapy can also better manage the course of AIDS if and when it occurs There are other rare disorders such as lymphocytopenia which result in the absence or dysfunction of CD4+ T cells These disorders produce similar symptoms, many of which are fatal


  • 1 Activation of naïve helper T cells
    • 11 Recognition signal 1
    • 12 Verification signal 2
    • 13 Proliferation
  • 2 Effector function
  • 3 Determination of the effector T cell response
    • 31 Th1/Th2 model
    • 32 Th17 helper cells
    • 33 THαβ helper cells
    • 34 Limitations to the Th1/Th2 model
  • 4 Role in disease
    • 41 Antitumor immunity
    • 42 Hypersensitivity
    • 43 HIV infection
  • 5 See also
  • 6 References
  • 7 External links

Activation of naïve helper T cellsedit

Following T cell development, matured, naïve T cells leave the thymus and begin to spread throughout the body, including the lymph nodes Naïve T cells are those T cells that have never been exposed to the antigen that they are programmed to respond to Like all T cells, they express the T cell receptor-CD3 complex The T cell receptor TCR consists of both constant and variable regions The variable region determines what antigen the T cell can respond to CD4+ T cells have TCRs with an affinity for Class II MHC, and CD4 is involved in determining MHC affinity during maturation in the thymus Class II MHC proteins are generally only found on the surface of specialised antigen-presenting cells APCs Specialised antigen presenting cells are primarily dendritic cells, macrophages and B cells, although dendritic cells are the only cell group that expresses MHC Class II constitutively at all times Some APCs also bind native or unprocessed antigens to their surface, such as follicular dendritic cells, but unprocessed antigens do not interact with T cells and are not involved in their activation The antigens that bind to MHC proteins are always short peptides, 8-10 amino acids long for MHC Class I, and up to 25 or so for MHC Class II

Recognition signal 1edit

Antigen presentation stimulates naïve CD8+ and CD4+ T cells to respectively become mature "cytotoxic" CD8+ cells and "helper" CD4+ cells

During an immune response, professional antigen-presenting cells APCs endocytose foreign material typically bacteria or viruses, which undergoes processing, then travel from the infection site to the lymph nodes Once at the lymph nodes, the APC begin to present antigen peptides that are bound to Class II MHC, allowing CD4+ T cells that express the specific TCRs against the peptide/MHC complex to activate

When a Th cell encounters and recognises the antigen on an APC, the TCR-CD3 complex binds strongly to the peptide-MHC complex present on the surface of professional APCs CD4, a co-receptor of the TCR complex, also binds to a different section of the MHC molecule These interactions bring these proteins closer together, allowing the intracellular kinases present on the TCR, CD3 and CD4 proteins to activate each other via phosphorylation With the assistance of a phosphatase present on the intracellular section of CD45 common leukocyte antigen, these molecules activate major Th cell intracellular pathways These active pathways are known as Signal 1 of T cell activation, as it is the first and primary pro-activation signal in a Th cell Upon subsequent encounters with a given antigen, memory T cells are re-activated using the same TCR pathways

The binding of the antigen-MHC to the TCR complex and CD4 may also help the APC and the Th cell adhere during Th cell activation, but the integrin protein LFA-1 on the T cell and ICAM on the APC are the primary molecules of adhesion in this cell interaction

It is unknown what role the relatively bulky extracellular region of CD45 plays during cell interactions, but CD45 has various isoforms that change in size depending on the Th cell's activation and maturation status For example, CD45 shortens in length following Th activation CD45RA+ to CD45RO+, but whether this change in length influences activation is unknown It has been proposed that the larger CD45RA+ may decrease the accessibility of the T cell receptor for the antigen-MHC molecule, thereby necessitating an increase in the affinity and specificity of the T cell for activation Once the activation has occurred however, CD45 shortens, allowing easier interactions and activation as an effector T helper cellcitation needed

Verification signal 2edit

Having received the first TCR/CD3 signal, the naïve T cell must activate a second independent biochemical pathway, known as Signal 2 This verification step is a protective measure to ensure that a T cell is responding to a foreign antigen If this second signal is not present during initial antigen exposure, the T cell presumes that it is auto-reactive This results in the cell becoming anergic anergy is generated from the unprotected biochemical changes of Signal 1 Anergic cells will not respond to any antigen in the future, even if both signals are present later on These cells are generally believed to circulate throughout the body with no value until they undergo apoptosis

The second signal involves an interaction between CD28 on the CD4+ T cell and the proteins CD80 B71 or CD86 B72 on the professional APCs Both CD80 and CD86 activate the CD28 receptor These proteins are also known as co-stimulatory molecules

Although the verification stage is necessary for the activation of naïve helper T cells, the importance of this stage is best demonstrated during the similar activation mechanism of CD8+ cytotoxic T cells As naïve CD8+ T cells have no true bias towards foreign sources, these T cells must rely on the activation of CD28 for confirmation that they recognise a foreign antigen as CD80/CD86 is only expressed by active APC's CD28 plays an important role in decreasing the risk of T cell auto-immunity against host antigens

Once the naïve T cell has both pathways activated, the biochemical changes induced by Signal 1 are altered, allowing the cell to activate instead of anergise The second signal is then obsolete; only the first signal is necessary for future activation This is also true for memory T cells, which is one example of learned immunity Faster responses occur upon reinfection because memory T cells have already undergone confirmation and can produce effector cells much sooner


Once the two-signal activation is complete the T helper cell Th then allows itself to proliferate It achieves this by releasing a potent T cell growth factor called interleukin 2 IL-2 which acts upon itself in an autocrine fashion Activated T cells also produce the alpha sub-unit of the IL-2 receptor CD25 or IL-2R, enabling a fully functional receptor that can bind with IL-2, which in turn activates the T cell's proliferation pathways

The autocrine or paracrine secretion of IL-2 can bind to that same Th cell or neighboring Th's via the IL-2R thus driving proliferation and clonal expansion The Th cells receiving both signals of activation and proliferation will then become Th0 cells T helper 0 cell that secrete IL-2, IL-4 and interferon gamma IFN-γ The Th0 cells will then differentiate into Th1 or Th2 cells depending on cytokine environment IFN-γ drives Th1 cell production while IL-10 and IL-4 inhibit Th1 cell production Conversely, IL-4 drives Th2 cell production and IFN-γ inhibits Th2 cells It should be noted that these cytokines are pleiotropic and carry out many other functions of the immune response

Effector functionedit

In 1991, three groups reported discovering CD154, which is the molecular basis of T cell helper function Seth Lederman at Columbia University generated an murine monoclonal antibody, 5c8 that inhibited contact-dependent T cell helper function in human cells which characterized the 32 kDa surface protein transiently expressed on CD4+ T cells1 Richard Armitage at Immunex cloned a cDNA encoding CD154 by screening an expression library with CD40-Ig5 Randolph Noelle at Dartmouth Medical School generated an antibody that bound a 39 kDa protein on murine T cells and inhibited helper function6

Determination of the effector T cell responseedit

Helper T cells are capable of influencing a variety of immune cells, and the T cell response generated including the extracellular signals such as cytokines can be essential for a successful outcome from infection In order to be effective, helper T cells must determine which cytokines will allow the immune system to be most useful or beneficial for the host Understanding exactly how helper T cells respond to immune challenges is currently of major interest in immunology, because such knowledge may be very useful in the treatment of disease and in increasing the effectiveness of vaccination

Th1/Th2 modeledit

Proliferating helper T cells that develop into effector T cells differentiate into two major subtypes of cells known as Th1 and Th2 cells also known as Type 1 and Type 2 helper T cells, respectively

Th1 helper cells are the host immunity effectors against intracellular bacteria and protozoa They are triggered by IL-12, IL-2 and their effector cytokine is IFN-γ The main effector cells of Th1 immunity are macrophages as well as CD8 T cells, IgG B cells, and IFN-γ CD4 T cells The key Th1 transcription factors are STAT4 and T-bet IFN-γ secreted by CD4 T cells can activate macrophages to phagocytose and digest intracellular bacteria and protozoa In addition, IFN-γ can activate iNOS to produce NOx free radicals to directly kill intracellular bacteria and protozoa Th1 overactivation against autoantigens will cause Type 4 delayed-type hypersensitivity Tuberculin reaction or Type 1 diabetes belong to this category of autoimmunity7

Th2 helper cells are the host immunity effectors against extracellular parasites including helminths They are triggered by IL-4 and their effector cytokines are IL-4, IL-5, IL-9, IL-10 and IL-13 The main effector cells are eosinophils, basophils, and mast cells as well as B cells, and IL-4/IL-5 CD4 T cells The key Th2 transcription factors are STAT6 and GATA38 IL-4 is the positive feedback cytokine for Th2 cells differentiation Besides, IL-4 stimulates B-cells to produce IgE antibodies, which in turn stimulate mast cells to release histamine, serotonin, and leukotriene to cause broncho-constriction, intestinal peristalsis, gastric fluid acidification to expel helminths IL-5 from CD4 T cells will activate eosinophils to attack helminths IL-10 suppresses Th1 cells differentiation and function of dendritic cells Th2 overactivation against autoantigen will cause Type1 IgE-mediated allergy and hypersensitivity Allergic rhinitis, atopic dermatitis, and asthma belong to this category of autoimmunity7 In addition to expressing different cytokines, Th2 cells also differ from Th1 cells in their cell surface glycans oligosaccharides, which makes them less susceptible to some inducers of cell death910

Th1/Th2 Model for helper T cells An antigen is ingested and processed by an APC It presents fragments from it to T cells The upper, Th0, is a T helper cell The fragment is presented to it by MHC211 IFN-γ, interferon γ; TGF-β, transforming growth factor β; mø, macrophage; IL-2, interleukin 2; IL-4, interleukin 4 Th1/Th2 dichotomy
Type 1/ Th1 Type 2/ Th27
Main partner cell type Macrophage, CD8+ T cell B-cell, eosinophil, mast cell
Cytokines produced interferon-γ and TNF-β Interleukin-2 interleukin-10 production has been reported in activated Th1 cell12 interleukin-4, interleukin-5, interleukin-6, interleukin-9, interleukin-10, interleukin-13
Immune stimulation promoted Cellular immune system Maximizes the killing efficacy of the macrophages and the proliferation of cytotoxic CD8+ T cells Also promotes the production of IgG, an opsonizing antibody Humoral immune system Stimulates B-cells into proliferation, to induce B-cell antibody class switching, and to increase neutralizing antibody production IgG, IgM and IgA as well as IgE antibodies
Other functions The Type 1 cytokine IFN-γ increases the production of interleukin-12 by dendritic cells and macrophages, and via positive feedback, IL-12 stimulates the production of IFN-γ in helper T cells, thereby promoting the Th1 profile IFN-gamma also inhibits the production of cytokines such as interleukin-4, an important cytokine associated with the Type 2 response, and thus it also acts to preserve its own response The Type 2 response promotes its own profile using two different cytokines Interleukin-4 acts on helper T cells to promote the production of Th2 cytokines including itself; it is auto-regulatory, while interleukin-10 IL-10 inhibits a variety of cytokines including interleukin-2 and IFN-γ in helper T cells and IL-12 in dendritic cells and macrophages The combined action of these two cytokines suggests that once the T cell has decided to produce these cytokines, that decision is preserved and also encourages other T cells to do the same

While we know about the types of cytokine patterns helper T cells tend to produce, we understand less about how the patterns themselves are decided Various evidence suggests that the type of APC presenting the antigen to the T cell has a major influence on its profile Other evidence suggests that the concentration of antigen presented to the T cell during primary activation influences its choice The presence of some cytokines such as the ones mentioned above will also influence the response that will eventually be generated, but our understanding is nowhere near complete

Th17 helper cellsedit

Main article: T helper 17 cell

Th17 helper cells are a subset of T helper cells developmentally distinct from Th1 and Th2 lineages producing interleukin 17 IL-17

THαβ helper cellsedit

THαβ helper cells provide the host immunity against viruses Their differentiation is triggered by IFN α/β or IL-10 Their key effector cytokine is IL-10 Their main effector cells are NK cells as well as CD8 T cells, IgG B cells, and IL-10 CD4 T cells The key THαβ transcription factors are STAT1 and STAT3 as well as IRFs IL-10 from CD4 T cells activate NK cells' ADCC to apoptose virus-infected cells and to induce host as well as viral DNA fragmentation IFN alpha/beta can suppress transcription to avoid virus replication and transmission Overactivation of THαβ against autoantigen will cause type 2 antibody-dependent cytotoxic hypersensitivity Myasthenia gravis or Graves' disease belong to this category13

Limitations to the Th1/Th2 modeledit

The interactions between cytokines from the Th1/Th2 model can be more complicated in some animals For example, the Th2 cytokine IL-10 inhibits cytokine production of both Th subsets in humans Human IL-10 hIL-10 suppresses the proliferation and cytokine production of all T cells and the activity of macrophages, but continues to stimulate plasma cells, ensuring that antibody production still occurs As such, hIL-10 is not believed to truly promote the Th2 response in humans, but acts to prevent over-stimulation of helper T cells while still maximising the production of antibodies

There are also other types of T cells that can influence the expression and activation of helper T cells, such as natural regulatory T cells, along with less common cytokine profiles such as the Th3 subset of helper T cells Terms such as "regulatory" and "suppression" have become ambiguous after the discovery that helper CD4+ T cells are also capable of regulating and suppressing their own responses outside of dedicated regulatory T cells

One major difference between regulatory T cells and effector T cells is that regulatory T cells typically serve to modulate and deactivate the immune response, while effector T cell groups usually begin with immune-promoting cytokines and then switch to inhibitory cytokines later in their life cycle The latter is a feature of Th3 cells, which transform into a regulatory subset after its initial activation and cytokine production

Both regulatory T cells and Th3 cells produce the cytokine transforming growth factor-beta TGF-β and IL-10 Both cytokines are inhibitory to helper T cells; TGF-β suppresses the activity of most of the immune system There is evidence to suggest that TGF-β may not suppress activated Th2 cells as effectively as it might suppress naive cells, but it is not typically considered a Th2 cytokine

The characterisation of another novel T helper subtype, T helper 17 cells Th1714 has cast further doubt on the basic Th1/Th2 model These IL-17 producing cells were initially described as a pathogenic population implicated in autoimmunity but are now thought to have their own distinct effector and regulatory functions Of note, recent evidence suggest that functional plasticity is an intrinsic capacity of T helper cells Indeed, a study in mice demonstrated that Th17 cells transform into Th1 cells in vivo15 A subsequent study furthermore showed that extensive T helper cell plasticity is also prominent in man16

Many of the cytokines in this article are also expressed by other immune cells see individual cytokines for details, and it is becoming clear that while the original Th1/Th2 model is enlightening and gives insight into the functions of helper T cells, it is far too simple to define its entire role or actions Some immunologists question the model completely, as some in vivo studies suggest that individual helper T cells usually do not match the specific cytokine profiles of the Th model, and many cells express cytokines from both profiles17 That said, the Th model has still played an important part in developing our understanding of the roles and behaviour of helper T cells and the cytokines they produce during an immune response

Recent scientific studies by Stockinger et al revealed that another T helper subset may exist Th9 cells are claimed to be an IL9 interleukin 9–producing T cell subset focused on defending helminth infections18

Role in diseaseedit

Considering the diverse and important role helper T cells play in the immune system, it is not surprising that these cells often influence the immune response against disease They also appear to make occasional mistakes, or generate responses that would be politely considered non-beneficial In the worst-case scenario, the helper T cell response could lead to a disaster and the fatality of the host Fortunately this is a very rare occurrence

Antitumor immunityedit

Main article: CD4+ T cells and antitumor immunity


The immune system must achieve a balance of sensitivity in order to respond to foreign antigens without responding to the antigens of the host itself When the immune system responds to very low levels of antigen that it usually shouldn't respond to, a hypersensitivity response occurs Hypersensitivity is believed to be the cause of allergy and some auto-immune disease

Hypersensitivity reactions can be divided into four types:

  • Type 1 hypersensitivity includes common immune disorders such as asthma, allergic rhinitis hay fever, eczema, urticaria hives and anaphylaxis These reactions all involve IgE antibodies, which require a Th2 response during helper T cell development Preventive treatments, such as corticosteroids and montelukast, focus on suppressing mast cells or other allergic cells; T cells do not play a primary role during the actual inflammatory response It's important to note that the numeral allocation of hypersensitivity "types" does not correlate and is completely unrelated to the "response" in the Th model
  • Type 2 and Type 3 hypersensitivity both involve complications from auto-immune or low affinity antibodies In both of these reactions, T cells may play an accomplice role in generating these auto-specific antibodies, although some of these reactions under Type 2 hypersensitivity would be considered normal in a healthy immune system for example, Rhesus factor reactions during child-birth is a normal immune response against child antigens The understanding of the role of helper T cells in these responses is limited but it is generally thought that Th2 cytokines would promote such disorders For example, studies have suggested that lupus SLE and other auto-immune diseases of similar nature can be linked to the production of Th2 cytokines
  • Type 4 hypersensitivity, also known as delayed type hypersensitivity, are caused via the over-stimulation of immune cells, commonly lymphocytes and macrophages, resulting in chronic inflammation and cytokine release Antibodies do not play a direct role in this allergy type T cells play an important role in this hypersensitivity, as they activate against the stimulus itself and promote the activation of other cells; particularly macrophages via Th1 cytokines

Other cellular hypersensitivities include cytotoxic T cell mediated auto-immune disease, and a similar phenomenon; transplant rejection Helper T cells are required to fuel the development of these diseases In order to create sufficient auto-reactive killer T cells, interleukin-2 must be produced, and this is supplied by CD4+ T cells CD4+ T cells can also stimulate cells such as natural killer cells and macrophages via cytokines such as interferon-gamma, encouraging these cytotoxic cells to kill host cells in certain circumstances

The mechanism that killer T cells use during auto-immunity is almost identical to their response against viruses, and some viruses have been accused of causing auto-immune diseases such as Type 1 diabetes mellitus Cellular auto-immune disease occurs because the host antigen recognition systems fail, and the immune system believes, by mistake, that a host antigen is foreign As a result, the CD8+ T cells treat the host cell presenting that antigen as infected, and go on to destroy all host cells or in the case of transplant rejection, transplant organ that express that antigen

Some of this section is a simplification Many auto-immune diseases are more complex A well-known example is rheumatoid arthritis, where both antibodies and immune cells are known to play a role in the pathology Generally the immunology of most auto-immune diseases is not well understood

HIV infectionedit

Perhaps the best example of the importance of CD4+ T cells is demonstrated with human immunodeficiency virus HIV infection HIV mainly targets lymphoid CD4+ T cells, but can infect other cells that express CD4 such as macrophages and dendritic cells both groups express CD4 at low levels

It has been proposed that during the non-symptomatic phase of HIV infection, the virus has a relatively low affinity towards T cells and has a higher affinity for macrophages, resulting in a slow kill rate of CD4+ T cells by the immune systemcitation needed This is initially compensated for via the production of new helper T cells from the thymus originally from the bone marrow Once the virus becomes lymphotropic or T-tropic however, it begins to infect CD4+ T cells far more efficiently likely due to a change in the co-receptors it binds to during infection, and the immune system is overwhelmed Of note, recent studies suggest that only ~5% of the lymphoid-derived CD4 T cells targeted by HIV are permissive and become productively infected with the virus More than 95% of the CD4 T cells that die are resting and are unable to support productive infection These cells undergo abortive infection with HIV19 Cell death is triggered when the host cell detects HIV foreign DNA intermediates and initiates a suicidal death pathway in an attempt to protect the host, leading to caspase-1 activation in inflammasomes, thus causing pyroptosis a highly inflammatory form of programmed cell death2021

At this point chronic inflammation ensues, and functional CD4+ T cell levels begin to decrease, eventually to a point where the CD4+ T cell population is too small to recognize the full range of antigens that could potentially be detected The depletion of CD4 T cells and the development of chronic inflammation are signature processes in HIV pathogenesis that propel progression to acquired immune deficiency syndrome AIDS CD4 T cell depleted to the cell count of less than 200cell/μL in blood during AIDS allows various pathogens to escape T cell recognition, thus allowing opportunistic infections that would normally elicit a helper T cell response to bypass the immune system22 While these complete bypass situations only occur when the helper T cell response is absolutely necessary for infection clearance, most infections increase in severity and/or duration because the immune system's helper T cells provide less efficient immune response

Two components of the immune system are particularly affected in AIDS, due to its CD4+ T cell dependency:

  1. CD8+ T cells are not stimulated as effectively during the AIDS stage of HIV infection, making AIDS patients very susceptible to most viruses, including HIV itself This decline in killing of CD4+ T cells results in the virus being produced for a longer period the infected CD4+ T cells are not killed as quickly, increasing the proliferation of the virus, and accelerating the development of the disease
  2. Antibody class switching declines significantly once helper T cell function fails The immune system loses its ability to improve the affinity of their antibodies, and are unable to generate B cells that can produce antibody groups such as IgG and IgA These effects are primarily due to the loss of any helper T cell that can interact with the B lymphocyte correctly Another symptom of AIDS is the reduction in antibody levels due to a decrease in Th2 cytokines and less interactions by helper T cells All of these complications result in an increased susceptibility to aggressive bacterial infections, especially in areas of the body not accessible by IgM antibodies

If the patient does not respond to or does not receive HIV treatment they will succumb usually to either cancers or infections; the immune system finally reaches a point where it is no longer coordinated or stimulated enough to deal with the disease

Inhibition of CD4 T-cell expansion during HIV infection may occur due to microbial translocation in an IL-10-dependent way Triggering PD-1 expressed on activated monocytes by its ligand PD-L1, induces IL-10 production which inhibits CD4 T-cell function23

See alsoedit

  • CD4+/CD8+ ratio
  • CD4+ T cells and antitumor immunity
  • CD8+ T cells


  1. ^ a b Lederman S, Yellin MJ, Krichevsky A, Belko J, Lee JJ, Chess L April 1992 "Identification of a novel surface protein on activated CD4+ T cells that induces contact-dependent B cell differentiation help" The Journal of Experimental Medicine 175 4: 1091–101 PMC 2119166  PMID 1348081 doi:101084/jem17541091 
  2. ^ Lederman S, Yellin MJ, Inghirami G, Lee JJ, Knowles DM, Chess L December 1992 "Molecular interactions mediating T-B lymphocyte collaboration in human lymphoid follicles Roles of T cell-B-cell-activating molecule 5c8 antigen and CD40 in contact-dependent help" Journal of Immunology 149 12: 3817–26 PMID 1281189 
  3. ^ Lederman S, Yellin MJ, Cleary AM, Pernis A, Inghirami G, Cohn LE, Covey LR, Lee JJ, Rothman P, Chess L March 1994 "T-BAM/CD40-L on helper T lymphocytes augments lymphokine-induced B cell Ig isotype switch recombination and rescues B cells from programmed cell death" Journal of Immunology 152 5: 2163–71 PMID 7907632 
  4. ^ "Entrez Gene: CD40LG CD40 ligand TNF superfamily, member 5, hyper-IgM syndrome" 
  5. ^ Armitage RJ, Fanslow WC, Strockbine L, Sato TA, Clifford KN, Macduff BM, Anderson DM, Gimpel SD, Davis-Smith T, Maliszewski CR, et al May 1992 "Molecular and biological characterization of a murine ligand for CD40" Nature 357 6373: 80–2 PMID 1374165 doi:101038/357080a0 
  6. ^ Noelle RJ, Roy M, Shepherd DM, Stamenkovic I, Ledbetter JA, Aruffo A July 1992 "A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells" Proc Natl Acad Sci U S A 89 14: 6550–4 PMC 49539  PMID 1378631 doi:101073/pnas89146550 
  7. ^ a b c Zhu, J; Paul, W E 2008 "CD4 T cells: Fates, functions, and faults" Blood 112 5: 1557–69 PMC 2518872  PMID 18725574 doi:101182/blood-2008-05-078154 
  8. ^ Wan, Yisong Y 2014-06-01 "GATA3: a master of many trades in immune regulation" Trends in Immunology 35 6: 233–242 PMC 4045638  PMID 24786134 doi:101016/jit201404002 
  9. ^ Maverakis E, Kim K, Shimoda M, Gershwin M, Patel F, Wilken R, Raychaudhuri S, Ruhaak LR, Lebrilla CB 2015 "Glycans in the immune system and The Altered Glycan Theory of Autoimmunity" J Autoimmun 57 6: 1–13 PMC 4340844  PMID 25578468 doi:101016/jjaut201412002 
  10. ^ Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD, Zwirner NW, Poirier F, Riley EM, Baum LG, Rabinovich GA 2007 "Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death" Nat Immunol 8: 825–34 
  11. ^ Rang, H P 2003 Pharmacology Edinburgh: Churchill Livingstone ISBN 0-443-07145-4  Page 223
  12. ^ Saraiva M; Christensen JR; Veldhoen M; Murphy TL; Murphy KM; O'Garra A 2009 "Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose" Immunity 31 2: 209–219 PMC 2791889  PMID 19646904 doi:101016/jimmuni200905012 
  13. ^ Hu, Wanchung 2007 Microarray analysis of PBMC gene expression profiles after Plasmodium falciparum malarial infection PhD thesis Johns Hopkins University 
  14. ^ Harrington, LE; Hatton, RD; Mangan, PR; Turner, Henrietta; Murphy, Theresa L; Murphy, Kenneth M; Weaver, Casey T 2005 "Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages" Nature Immunology 6 11: 1023–32 PMID 16200070 doi:101038/ni1254 
  15. ^ Hirota K, Duarte JH, Veldhoen M, Hornsby E, Li Y, Cua DJ, Ahlfors H, Wilhelm C, Tolaini M, Menzel U, Garefalaki A, Potocnik AJ, Stockinger B Nat Immunol; Duarte; Veldhoen; Hornsby; Li; Cua; Ahlfors; Wilhelm; Tolaini; Menzel; Garefalaki; Potocnik; Stockinger 2011 "Fate mapping of IL-17-producing T cells in inflammatory responses" Nature Immunology 12 3: 255–63 PMC 3040235  PMID 21278737 doi:101038/ni1993 CS1 maint: Multiple names: authors list link
  16. ^ Larsen M, Arnaud L, Hie M, Parizot C, Dorgham K, Shoukry M, Kemula M, Barete S, Derai D, Sauce D, Amoura Z, Pene J, Yssel H, Gorochov G Eur J Immunol; Arnaud; Hié; Parizot; Dorgham; Shoukry; Kemula; Barete; Derai; Sauce; Amoura; Pène; Yssel; Gorochov 2011 "Multiparameter grouping delineates heterogeneous populations of human IL-17 and/or IL-22 T-cell producers that share antigen specificities with other T-cell subsets" European Journal of Immunology UPMC Paris 06 Institut National de la Santé et de la Recherche Médicale Inserm UMR-S 945 41 9: 2596–2605 PMID 21688259 doi:101002/eji201041131 CS1 maint: Multiple names: authors list link
  17. ^ Nakayamada S; Takahashi H; Kanno Y; O'Shea JJ 2012 "Helper T cell diversity and plasticity" Current Opinion in Immunology 24 3: 297–302 PMC 3383341  PMID 22341735 doi:101016/jcoi201201014 
  18. ^ Veldhoen and Stockinger, Dardalhon and Kuchroo both papers from Nature Immunology 2008
  19. ^ Doitsh G; et al 2010 "Abortive HIV Infection Mediates CD4 T Cell Depletion and Inflammation in Human Lymphoid Tissue" Cell 143 5: 789–801 PMC 3026834  PMID 21111238 doi:101016/jcell201011001 
  20. ^ Doitsh, G; Galloway, N L; Geng, X; Yang, Z; Monroe, K M; Zepeda, O; Hunt, P W; Hatano, H; Sowinski, S; Muñoz-Arias, I; Greene, W C 2014 "Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection" Nature 505 7484: 509–14 PMC 4047036  PMID 24356306 doi:101038/nature12940 
  21. ^ Monroe KM; et al 2013 "IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV" Science 343 6169: 428–32 PMC 3976200  PMID 24356113 doi:101126/science1243640 
  22. ^ "CD4 Count" wwwaidsgov Retrieved 2015-04-30 
  23. ^ Said EA; Dupuy FP; Trautmann L; Zhang Y; Shi Y; El-Far M; Hill BJ; Noto A; Ancuta P; Peretz Y; Fonseca SG; Van Grevenynghe J; Boulassel MR; Bruneau J; Shoukry NH; Routy JP; Douek DC; Haddad EK; Sekaly RP 2010 "Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection" Nature Medicine 16 4: 452–459 PMC 4229134  PMID 20208540 doi:101038/nm2106 
  • Kanno Y, Vahedi G, Hirahara K, Singleton K, O'Shea JJ 2012 "Transcriptional and Epigenetic Control of T Helper Cell Specification: Molecular Mechanisms Underlying Commitment and Plasticity" Annual Review of Immunology 30: 707–731 PMC 3314163  PMID 22224760 doi:101146/annurev-immunol-020711-075058 
  • In SLE patients, T helper type 1 polarisation is more abundant rather than type 2, where the main cytokine profile are Inf gama from T cells and its consequence interferon alpha high range production by DC

External linksedit

  • "T-cell Group" T-Cells Cardiff University 
  • Doitsh G, Greene WC 2016 "Dissecting How CD4 T Cells Are Lost During HIV Infection" Cell Host Microbe 19 3: 280–91 PMC 4835240  PMID 26962940 doi:101016/jchom201602012 

t helper cell (th)-2 type, t helper cell 2, t helper cell activation, t helper cell and associated markers, t helper cell and phagocytosis, t helper cell differentiation, t helper cell function, t helper cell markers, t helper cell videos, t helper cells

T helper cell Information about

T helper cell

  • user icon

    T helper cell beatiful post thanks!


T helper cell
T helper cell
T helper cell viewing the topic.
T helper cell what, T helper cell who, T helper cell explanation

There are excerpts from wikipedia on this article and video

Random Posts



A book is a set of written, printed, illustrated, or blank sheets, made of ink, paper, parchment, or...
Boston Renegades

Boston Renegades

Boston Renegades was an American women’s soccer team, founded in 2003 The team was a member of the U...
Sa Caleta Phoenician Settlement

Sa Caleta Phoenician Settlement

Sa Caleta Phoenician Settlement can be found on a rocky headland about 10 kilometers west of Ibiza T...

Bodybuildingcom is an American online retailer based in Boise, Idaho, specializing in dietary supple...