Sulbactamsulbactam ampicillin, sulbactam
Sulbactam is a β-lactamase inhibitor This drug is given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys the antibiotics
- 1 Mechanism
- 2 Uses
- 3 See also
- 4 References
- 5 Further reading
Sulbactam is an irreversible inhibitor of β-lactamase; it binds to the enzyme and does not allow it to degrade the antibiotic
Sulbactam is able to inhibit the most common forms of β-lactamase but is not able to interact with the AmpC cephalosporinase Thus, it confers little protection against bacteria such as Pseudomonas aeruginosa, Citrobacter, Enterobacter, and Serratia, which often express this gene
In the United States, sulbactam is combined to form ampicillin/sulbactam It does possess some antibacterial activity when administered alone, but it is too weak to have any clinical importance Its use in the UK is restricted to hospitals
Recently, its use in treating Acinetobacter septicemia is receiving renewed interest
- ^ Totir MA, Helfand MS, Carey MP, et al August 2007 "Sulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamase" Biochemistry 46 31: 8980–7 doi:101021/bi7006146 PMC 2596720 PMID 17630699
- Singh GS January 2004 "Beta-lactams in the new millennium Part-II: cephems, oxacephems, penams and sulbactam" Mini Rev Med Chem 4 1: 93–109 doi:102174/1389557043487547 PMID 14754446
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