Wed . 18 Nov 2018

Steen Willadsen

steen willadsen, steen willadsen 1984
Steen Malte Willadsen born 1943 in Copenhagen, Denmark is a scientist credited with being the first to clone a mammal using nuclear transfer

Willadsen graduated from the Royal Veterinary College of Copenhagen 1969, and received a PhD in reproductive physiology from there 1973 In 1984, at the British Agricultural Research Council's Institute of Animal Physiology, Cambridge, he successfully used cells from early embryos to clone sheep by nuclear transfer[2][3] The procedure he developed was essentially the one used a decade later by Wilmut et al to produce Dolly, the sheep, although in the latter case, nuclei from a mature sheep, ie not from sheep embryos, were used Prior to the nuclear transfer experiments, Willadsen had developed methods for freezing sheep and cow embryos,[4] and embryo manipulation methods for producing genetically identical animals, primarily identical twins in sheep, cattle, pigs, and horses,[5] and for producing mammalian chimaeras, including interspecies chimaeras[6]

References

  1. ^ Reproduction, Fertility and Development 2005, 17
  2. ^ Nuclear transplantation in sheep embryos
  3. ^ Willadsen, SM 1989: Cloning of sheep and cow embryos Genome 31, 956 - 962
  4. ^ Willadsen, SM 1977: Factors affecting the survival of sheep embryos during deep-freezing and thawing in The Freezing of Mammalian Embryos Ciba Found Symp 52,NS, Eds Elliott and Whelan, Elsevier/ Excpt Medica/ NHolland, Amsterdam, 175 - 189
  5. ^ Willadsen, SM 1979: A method for culture of micromanipulated sheep embryos, and its use to produce monozygotic twins Nature, Lond 277,298 - 300
  6. ^ Fehilly, CB, Willadsen, SM, and Tucker, EM 1984: Inter-specific chimaerism between domestic sheep Ovis ariesand domestic goat Capra hircus Nature, Lond 307, 634 - 636

External links

  • Scientist Profile : Steen Willadsen


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    29.10.2014


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