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Specific granule

specific granule dietní cena, specific granule deficiency
Specific granules are secretory vesicles found exclusively in cells of the immune system called granulocytes

It is sometimes described as applying specifically to neutrophils,[1] and sometimes the term is applied to other types of cells[2]

These granules store a mixture of cytotoxic molecules, including many enzymes and antimicrobial peptides, that are released by a process called degranulation following activation of the granulocyte by an immune stimulus

Specific granules are also known as "secondary granules"[3]


  • 1 Contents
  • 2 Clinical significance
  • 3 References
  • 4 External links


Examples of cytotoxic molecule stored by specific granules in different granulocytes include:

  • Neutrophil: alkaline phosphatase, lactoferrin, lysozyme, NADPH oxidase
  • Eosinophil: cathepsin, major basic protein
  • Basophil: heparin, histamine not directly cytotoxic

Clinical significance

A specific granule deficiency can be associated with CEBPE[4]


  1. ^ "Definition: specific granule from Online Medical Dictionary" 
  2. ^ Okuda M, Takenaka T, Kawabori S, Ogami Y July 1981 "Ultrastructural study of the specific granule of the human eosinophil" J Submicrosc Cytol 13 3: 465–71 PMID 7334549 
  3. ^ John P Greer; Maxwell Myer Wintrobe 1 December 2008 Wintrobe's clinical hematology Lippincott Williams & Wilkins pp 173– ISBN 978-0-7817-6507-7 Retrieved 10 November 2010 
  4. ^ Online Mendelian Inheritance in Man OMIM SPECIFIC GRANULE DEFICIENCY; SGD -245480

External links

  • Neutrophil granules at savsk

specific granule, specific granule deficiency, specific granule dietní cena, specific granules, specific granules of neutrophils

Specific granule Information about

Specific granule

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