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Smooth muscle tumor of uncertain malignant potential

smooth muscle tumor of uncertain malignant potential, smooth muscle tumor of uncertain malignant potential stump
Smooth muscle tumor of uncertain malignant potential, abbreviated STUMP, is an uncommon tumor of the uterine smooth muscle that may behave like a benign tumor or a cancerous tumor

This tumor should not be confused with the prostatic stromal tumor of uncertain malignant potential which may be abbreviated the same way STUMP

The Bell criteria were developed to help categorize them and differentiate them from their main differential diagnoses, leiomyosarcoma and uterine leiomyoma

Contents

  • 1 Bell Criteria
    • 11 Atypia
    • 12 Mitotic figures
    • 13 Necrosis
    • 14 Algorithm
  • 2 See also
  • 3 References

Bell Criteriaedit

Atypiaedit

  • none
  • minimal: smooth nuclei, smooth contours, minimal variation in nuclear size, shape, and evenly distributed chromatin
  • moderate: many large, plump, irregular nuclei, 1-2 mitotic figures
  • severe: obvious pleomorphism, enlarged bizarre nuclei with dense chromatin, giant cells, often multinucleated, enlarged, atypical nucleoli

Mitotic figuresedit

Evaluation of the mitotic figures in a STUMP requires evaluation of 3 specific criteria

  1. Hairy extensions of chromatin must be present, extending from a central clot-like dense mass of chromosomes Hairy extensions from an empty center favor a non-mitosis Count 4 sets of 10 fields in the area of highest mitotic activity and use the highest count
  2. No nuclear membrane
  3. Rule out lymphocytes, mast cells, stripped nuclei, degenerated cells, and precipitated hematoxylin

Necrosisedit

Coagulative tumor cell necrosis is common in clinically malignant smooth muscle cell tumors It consists of an abrupt transition between necrotic cells and preserved cells Ghost nuclei from necrotic cells are often seen, but inflammatory cells are uncommon Hyalinizing necrosis is more common in leiomyomas It consists of a zone of hyalinized collagen between dead cells and preserved cells, commonly eosinophilic If dead nuclei present, they are uniform and the chromatin is often Necrosis secondary to ulceration in submucous leiomyomas features acute inflammatory cells and a peripheral reparative process, whereas ghost outlines of nuclei are usually inconspicuous or absent

Algorithmedit

  • Bell's criteria do not apply to extrauterine tumors
  • No or mild atypia, no tumor cell necrosis ⇒ leiomyoma If 5 or more mitotic figures are present in 10 high powered fields but the behavior still appears benign, may append “with significant mitotic activity”
  • Moderate to severe atypia without tumor cell necrosis
    • atypical leiomyoma if < 10 mitotic figures per high power field or
    • leiomyosarcoma if ≥ 10 mitotic figures per high power field
  • Moderate to severe atypia and tumor cell necrosis ⇒ leiomyosarcoma mitotic figures don’t matter

See alsoedit

  • Prostatic stromal tumor of uncertain malignant potential

Referencesedit

  • Guntupalli SR, Ramirez PT, Anderson ML, Milam MR, Bodurka DC, Malpica A June 2009 "Uterine smooth muscle tumor of uncertain malignant potential: a retrospective analysis" Gynecol Oncol 113 3: 324–6 PMID 19342083 doi:101016/jygyno200902020 
  • Ng JS, Han A, Chew SH, Low J August 2010 "A clinicopathologic study of uterine smooth muscle tumours of uncertain malignant potential STUMP" PDF Ann Acad Med Singap 39 8: 625–8 PMID 20838704 
  • Ip PP, Cheung AN, Clement PB July 2009 "Uterine smooth muscle tumors of uncertain malignant potential STUMP: a clinicopathologic analysis of 16 cases" Am J Surg Pathol 33 7: 992–1005 PMID 19417585 doi:101097/PAS0b013e3181a02d1c 
  • Chen WY, Yang AH, Liu HC April 1991 "Spindle cell stromal tumors of gastrointestinal tract: a histological and immunohistochemical study" Zhonghua Yi Xue Za Zhi Taipei 47 4: 219–27 PMID 1710946 
  • full citation needed http://wwwpathologyoutlinescom/topic/uterusSTUMPhtml

smooth muscle tumor of uncertain malignant potential, smooth muscle tumor of uncertain malignant potential stump


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    29.10.2014


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