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SLPI, splix io
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Identifiers Aliases SLPI, ALK1, ALP, BLPI, HUSI, HUSI-I, MPI, WAP4, WFDC4, secretory leukocyte peptidase inhibitor External IDs MGI: 109297 HomoloGene: 2305 GeneCards: SLPI
Gene location Human
Chr Chromosome 20 human
Band 20q1312 Start 45,252,239 bp
End 45,254,564 bp
RNA expression pattern
More reference expression data
Orthologs Species Human Mouse Entrez
RefSeq mRNA



RefSeq protein



Location UCSC Chr 20: 4525 – 4525 Mb Chr 2: 16435 – 16439 Mb PubMed search Wikidata
  • ^ a b c GRCh38: Ensembl release 89: ENSG00000124107 - Ensembl, May 2017
  • ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017002 - Ensembl, May 2017
  • ^ "Human PubMed Reference:" 
  • ^ "Mouse PubMed Reference:" 
  • ^ Stetler G, Brewer MT, Thompson RC Oct 1986 "Isolation and sequence of a human gene encoding a potent inhibitor of leukocyte proteases" Nucleic Acids Research 14 20: 7883–96 doi:101093/nar/14207883 PMC 311822  PMID 3640338 
  • ^ Clauss A, Lilja H, Lundwall A Nov 2002 "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein" The Biochemical Journal 368 Pt 1: 233–42 doi:101042/BJ20020869 PMC 1222987  PMID 12206714 
  • ^ a b "Entrez Gene: SLPI secretory leukocyte peptidase inhibitor" 
  • ^ a b c McNeely TB, Dealy M, Dripps DJ, Orenstein JM, Eisenberg SP, Wahl SM Jul 1995 "Secretory leukocyte protease inhibitor: a human saliva protein exhibiting anti-human immunodeficiency virus 1 activity in vitro" The Journal of Clinical Investigation 96 1: 456–64 doi:101172/JCI118056 PMC 185219  PMID 7615818 
  • ^ Nagashunmugam T, Malamud D, Davis C, Abrams WR, Friedman HM Dec 1998 "Human submandibular saliva inhibits human immunodeficiency virus type 1 infection by displacing envelope glycoprotein gp120 from the virus" The Journal of Infectious Diseases 178 6: 1635–41 doi:101086/314511 PMID 9815215 
  • ^ Shugars DC, Wahl SM Jul 1998 "The role of the oral environment in HIV-1 transmission" Journal of the American Dental Association 129 7: 851–8 doi:1014219/jadaarchive19980349 PMID 9685760 
  • ^ Malamud D, Friedman HM 1993-01-01 "HIV in the oral cavity: virus, viral inhibitory activity, and antiviral antibodies: a review" Critical Reviews in Oral Biology and Medicine 4 3-4: 461–6 PMID 8373998 
  • ^ Hoffmann M, Quabius ES, Tribius S, Hebebrand L, Görögh T, Halec G, Kahn T, Hedderich J, Röcken C, Haag J, Waterboer T, Schmitt M, Giuliano AR, Kast WM May 2013 "Human papillomavirus infection in head and neck cancer: the role of the secretory leukocyte protease inhibitor" Oncology Reports 29 5: 1962–8 doi:103892/or20132327 PMC 3658815  PMID 23467841 
  • ^ Pierce Campbell CM, Guan W, Sprung R, Koomen JM, O'Keefe MT, Ingles DJ, Abrahamsen M, Giuliano AR Dec 2013 "Quantification of secretory leukocyte protease inhibitor SLPI in oral gargle specimens collected using mouthwash" Journal of Immunological Methods 400-401: 117–21 doi:101016/jjim201310005 PMC 3990009  PMID 24140751 
  • ^ Quabius ES, Möller P, Haag J, Pfannenschmidt S, Hedderich J, Görögh T, Röcken C, Hoffmann M Mar 2014 "The role of the antileukoprotease SLPI in smoking-induced human papillomavirus-independent head and neck squamous cell carcinomas" International Journal of Cancer 134 6: 1323–34 doi:101002/ijc28462 PMID 23996702 
  • ^ Tseng CC, Tseng CP Jun 2000 "Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement" FEBS Letters 475 3: 232–6 doi:101016/s0014-57930001700-2 PMID 10869562 
  • ^ Py B, Basmaciogullari S, Bouchet J, Zarka M, Moura IC, Benhamou M, Monteiro RC, Hocini H, Madrid R, Benichou S 2009-01-01 "The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane" PLOS ONE 4 3: e5006 doi:101371/journalpone0005006 PMC 2659420  PMID 19333378 
  • ^ Ma G, Greenwell-Wild T, Lei K, Jin W, Swisher J, Hardegen N, Wild CT, Wahl SM Nov 2004 "Secretory leukocyte protease inhibitor binds to annexin II, a cofactor for macrophage HIV-1 infection" The Journal of Experimental Medicine 200 10: 1337–46 doi:101084/jem20041115 PMC 2211913  PMID 15545357 
  • ^ Woodham AW, Da Silva DM, Skeate JG, Raff AB, Ambroso MR, Brand HE, Isas JM, Langen R, Kast WM 2012-01-01 "The S100A10 subunit of the annexin A2 heterotetramer facilitates L2-mediated human papillomavirus infection" PLOS ONE 7 8: e43519 doi:101371/journalpone0043519 PMC 3425544  PMID 22927980 
  • Further reading

    • Reviglio VE, Sambuelli RH, Olmedo A, Falco M, Echenique J, O'Brien TP, Kuo IC 2007 "Secretory leukocyte protease inhibitor is an inducible antimicrobial peptide expressed in Staphylococcus aureus endophthalmitis" Mediators of Inflammation 2007: 93857 doi:101155/2007/93857 PMC 2234354  PMID 18274645 
    • Fritz H May 1988 "Human mucus proteinase inhibitor human MPI Human seminal inhibitor I HUSI-I, antileukoprotease ALP, secretory leukocyte protease inhibitor SLPI" Biological Chemistry Hoppe-Seyler 369 Suppl: 79–82 PMID 3060147 
    • Sallenave JM 2003 "The role of secretory leukocyte proteinase inhibitor and elafin elastase-specific inhibitor/skin-derived antileukoprotease as alarm antiproteinases in inflammatory lung disease" Respiratory Research 1 2: 87–92 doi:101186/rr18 PMC 59548  PMID 11667971 
    • Rogaev EI, Keryanov SA, Malyako YK Jul 1992 "Dinucleotide repeat polymorphisms at the P1, HBE1 and MYH7 loci" Human Molecular Genetics 1 4: 285 doi:101093/hmg/14285 PMID 1363870 
    • Abe T, Kobayashi N, Yoshimura K, Trapnell BC, Kim H, Hubbard RC, Brewer MT, Thompson RC, Crystal RG Jun 1991 "Expression of the secretory leukoprotease inhibitor gene in epithelial cells" The Journal of Clinical Investigation 87 6: 2207–15 doi:101172/JCI115255 PMC 296981  PMID 1674946 
    • Sallenave JM, Ryle AP Jan 1991 "Purification and characterization of elastase-specific inhibitor Sequence homology with mucus proteinase inhibitor" Biological Chemistry Hoppe-Seyler 372 1: 13–21 doi:101515/bchm31991372113 PMID 2039600 
    • Eisenberg SP, Hale KK, Heimdal P, Thompson RC May 1990 "Location of the protease-inhibitory region of secretory leukocyte protease inhibitor" The Journal of Biological Chemistry 265 14: 7976–81 PMID 2110563 
    • Grütter MG, Fendrich G, Huber R, Bode W Feb 1988 "The 25 A X-ray crystal structure of the acid-stable proteinase inhibitor from human mucous secretions analysed in its complex with bovine alpha-chymotrypsin" The EMBO Journal 7 2: 345–51 PMC 454325  PMID 3366116 
    • Thompson RC, Ohlsson K Sep 1986 "Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase" Proceedings of the National Academy of Sciences of the United States of America 83 18: 6692–6 doi:101073/pnas83186692 PMC 386575  PMID 3462719 
    • Seemüller U, Arnhold M, Fritz H, Wiedenmann K, Machleidt W, Heinzel R, Appelhans H, Gassen HG, Lottspeich F Apr 1986 "The acid-stable proteinase inhibitor of human mucous secretions HUSI-I, antileukoprotease Complete amino acid sequence as revealed by protein and cDNA sequencing and structural homology to whey proteins and Red Sea turtle proteinase inhibitor" FEBS Letters 199 1: 43–8 doi:101016/0014-57938681220-0 PMID 3485543 
    • Heinzel R, Appelhans H, Gassen G, Seemüller U, Machleidt W, Fritz H, Steffens G Oct 1986 "Molecular cloning and expression of cDNA for human antileukoprotease from cervix uterus" European Journal of Biochemistry / FEBS 160 1: 61–7 doi:101111/j1432-10331986tb09940x PMID 3533531 
    • Westin U, Fryksmark U, Polling A, Ohlsson K Mar 1994 "Localisation of secretory leucocyte proteinase inhibitor mRNA in nasal mucosa" Acta Oto-Laryngologica 114 2: 199–202 doi:103109/00016489409126042 PMID 7515550 
    • Ohlsson K, Bjartell A, Lilja H 1995 "Secretory leucocyte protease inhibitor in the male genital tract: PSA-induced proteolytic processing in human semen and tissue localization" Journal of Andrology 16 1: 64–74 PMID 7539415 
    • Belorgey D, Dirrig S, Amouric M, Figarella C, Bieth JG Jan 1996 "Inhibition of human pancreatic proteinases by mucus proteinase inhibitor, eglin c and aprotinin" The Biochemical Journal 313 Pt 2 2: 555–60 PMC 1216943  PMID 8573092 
    • Kikuchi T, Abe T, Hoshi S, Matsubara N, Tominaga Y, Satoh K, Nukiwa T Dec 1998 "Structure of the murine secretory leukoprotease inhibitor Slpi gene and chromosomal localization of the human and murine SLPI genes" American Journal of Respiratory Cell and Molecular Biology 19 6: 875–80 doi:101165/ajrcmb1963314 PMID 9843921 
    • Westin U, Polling A, Ljungkrantz I, Ohlsson K Apr 1999 "Identification of SLPI secretory leukocyte protease inhibitor in human mast cells using immunohistochemistry and in situ hybridisation" Biological Chemistry 380 4: 489–93 doi:101515/BC1999063 PMID 10355635 
    • Mulligan MS, Lentsch AB, Huber-Lang M, Guo RF, Sarma V, Wright CD, Ulich TR, Ward PA Mar 2000 "Anti-inflammatory effects of mutant forms of secretory leukocyte protease inhibitor" The American Journal of Pathology 156 3: 1033–9 doi:101016/S0002-94401064971-1 PMC 1876846  PMID 10702419 
    • Nyström M, Bergenfeldt M, Ljungcrantz I, Lindeheim A, Ohlsson K 2000 "Production of secretory leucocyte protease inhibitor SLPI in human pancreatic beta-cells" Mediators of Inflammation 8 3: 147–51 doi:101080/09629359990478 PMC 1781797  PMID 10704052 
    • Si-Tahar M, Merlin D, Sitaraman S, Madara JL Jun 2000 "Constitutive and regulated secretion of secretory leukocyte proteinase inhibitor by human intestinal epithelial cells" Gastroenterology 118 6: 1061–71 doi:101016/S0016-50850070359-3 PMID 10833481 
    • Victor E Reviglio, Andres Grenat, Federico Pegoraro, Ruben H Sambuelli, Tayyib Rana, and Irene C Kuo Secretory Leukoprotease Inhibitor: A Native Antimicrobial Protein in the Innate Immune Response in a Rat Model of S aureus Keratitis Journal of OphthalmologyVolume 2009 2009, Article ID 259393, 5 pages doi:101155/2009/259393

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