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sialolithiasis, sialolithiasis pictures
Sialolithiasis also termed salivary calculi,1 or salivary stones,1 is a condition where a calcified mass or sialolith forms within a salivary gland, usually in the duct of the submandibular gland also termed "Wharton's duct" Less commonly the parotid gland or rarely the sublingual gland or a minor salivary gland may develop salivary stones

The usual symptoms are pain and swelling of the affected salivary gland, both of which get worse when salivary flow is stimulated, eg with the sight, thought, smell or taste of food, or with hunger or chewing This is often termed "mealtime syndrome"2 Inflammation or infection of the gland may develop as a result Sialolithiasis may also develop because of the presence of existing chronic infection of the glands, dehydration eg use of phenothiazines, Sjögren's syndrome and/or increased local levels of calcium, but in many instances the cause is idiopathic unknown

The condition is usually managed by removing the stone, and several different techniques are available Rarely, removal of the submandibular gland may become necessary in cases of recurrent stone formation Sialolithiasis is common, accounting for about 50% of all disease occurring in the major salivary glands and causing symptoms in about 045% of the general population Persons aged 30–60 and males are more likely to develop sialolithiasis2


  • 1 Classification
  • 2 Signs and symptoms
  • 3 Causes
  • 4 Diagnosis
  • 5 Treatment
  • 6 Epidemiology
  • 7 References


The term is derived from the Greek words sialon saliva and lithos stone, and the Latin -iasis meaning "process" or "morbid condition" A calculus plural calculi is a hard, stone-like concretion that forms within an organ or duct inside the body They are usually made from mineral salts, and other types of calculi include tonsiloliths tonsil stones and renal calculi kidney stones Sialolithiasis refers to the formation of calculi within a salivary gland If a calculus forms in the duct that drains the saliva from a salivary gland into the mouth, then saliva will be trapped in the gland This may cause painful swelling and inflammation of the gland Inflammation of a salivary gland is termed sialadenitis Inflammation associated with blockage of the duct is sometimes termed "obstructive sialadenitis" Because saliva is stimulated to flow more with the thought, sight or smell of food, or with chewing, pain and swelling will often get suddenly worse just before and during a meal "peri-prandial", and then slowly decrease after eating, this is termed meal time syndrome However, calculi are not the only reasons that a salivary gland may become blocked and give rise to the meal time syndrome Obstructive salivary gland disease, or obstructive sialadenitis, may also occur due to fibromucinous plugs, duct stenosis, foreign bodies, anatomic variations, or malformations of the duct system leading to a mechanical obstruction associated with stasis of saliva in the duct2

Salivary stones may be divided according to which gland they form in About 85% of stones occur in the submandibular gland,3 and between 5-10% occur in the parotid gland2 In about 0-5% of cases, the sublingual gland or a minor salivary gland is affected2 When minor glands are rarely involved, caliculi are more likely in the minor glands of the buccal mucosa and the maxillary labial mucosa4 Submandibular stones are further classified as anterior or posterior in relation to an imaginary transverse line drawn between the mandibular first molar teeth Stones may be radiopaque, ie they will show up on conventional radiographs, or radiolucent, where they not be visible on radiographs although some of their effects on the gland may still be visible They may also symptomatic or asymptomatic, according to whether they cause any problems or not

Signs and symptomsedit

Swelling of the submandibular gland as seen from the outside The stone seen in the submandicular duct on the persons right side

Signs and symptoms are variable and depend largely upon whether the obstruction of the duct is complete or partial, and how much resultant pressure is created within the gland1 The development of infection in the gland also influences the signs and symptoms

  • Pain, which is intermittent, and may suddenly get worse before mealtimes, and then slowly get better partial obstruction3
  • Swelling of the gland, also usually intermittent, often suddenly appearing or increasing before mealtimes, and then slowly going down partial obstruction3
  • Tenderness of the involved gland3
  • Palpable hard lump, if the stone is located near the end of the duct13 If the stone is near the submandibular duct orifice, the lump may be felt under the tongue
  • Lack of saliva coming from the duct total obstruction3
  • Erythema redness of the floor of the mouth infection3
  • Pus discharging from the duct infection3
  • Cervical lymphadenitis infection3

Rarely, when stones form in the minor salivary glands, there is usually only slight local swelling in the form of a small nodule and tenderness1


The major salivary glands paired on each side 1 Parotid gland, 2 Submandibular gland, 3 Sublingual gland

There are thought to be a series of stages that lead to the formation of a calculus lithogenesis Initially, factors such as abnormalities in calcium metabolism,3 dehydration,2 reduced salivary flow rate,2 altered acidity pH of saliva caused by oropharyngeal infections,2 and altered solubility of crystalloids,2 leading to precipitation of mineral salts, are involved Other sources state that no systemic abnormality of calcium or phosphate metabolism is responsible1

The next stage involves the formation of a nidus which is successively layered with organic and inorganic material, eventually forming a calcified mass23 In about 15-20% of cases the sialolith will not be sufficiently calcified to appear radiopaque on a radiograph,3 and therefore be difficult to detect

Other sources suggest a retrograde theory of lithogenesis, where food debris, bacteria or foreign bodies from the mouth enter the ducts of a salivary gland and are trapped by abnormalities in the sphincter mechanism of the duct opening the papilla, which are reported in 90% of cases Fragments of bacteria from salivary calculi were reported to be Streptococci species which are part of the normal oral microbiota and are present in dental plaque2

Stone formation occurs most commonly in the submandibular gland for several reasons The concentration of calcium in saliva produced by the submandibular gland is twice that of the saliva produced by the parotid gland3 The submandibular gland saliva is also relatively alkaline and mucous The submandibular duct Wharton's duct is long, meaning that saliva secretions must travel further before being discharged into the mouth3 The duct possesses two bends, the first at the posterior border of the mylohyoid muscle and the second near the duct orifice3 The flow of saliva from the submandibular gland is often against gravity due to variations in the location of the duct orifice3 The orifice itself is smaller than that of the parotid3 These factors all promote slowing and stasis of saliva in the submandibular duct, making the formation of an obstruction with subsequent calcification more likely

Salivary calculi sometimes are associated with other salivary diseases, eg sialoliths occur in two thirds of cases of chronic sialadenitis,4 although obstructive sialadenitis is often a consequence of sialolithiasis Gout may also cause salivary stones,4 although in this case they are composed of uric acid crystals rather than the normal composition of salivary stones


Ultrasound image of sialolithiasis Play media Stone resulting in inflammation and dilation of the duct5

Diagnosis is usually made by characteristic history and physical examination Diagnosis can be confirmed by x-ray 80% of salivary gland calculi are visible on x-ray, by sialogram, or by ultrasound


Salivary gland stone and the hole left behind from the operation

Some current treatment options are:

  • Non-invasive:
    • For small stones, hydration, moist heat therapy, NSAIDs nonsteroidal anti-inflammatory drugs occasionally, and having the patient take any food or beverage that is bitter and/or sour Sucking on citrus fruits, such as a lemon or orange, may increase salivation and promote spontaneous expulsion of the stone
    • Some stones may be massaged out by a specialist
    • Shock wave therapy Extracorporeal shock wave lithotripsy6
  • Minimally invasive:
    • Sialendoscopy
  • Surgical:
    • An ENT or oral/maxillofacial surgeon may cannulate the duct to remove the stone sialectomy
    • A surgeon may make a small incision near the stone to remove it
    • In some cases when stones continually reoccur the offending salivary duct is removed
  • Supporting treatment:
    • To prevent infection while the stone is lodged in the duct, antibiotics are sometimes used


The prevalence of salivary stones in the general population is about 12% according to post mortem studies, but the prevalence of salivary stones which cause symptoms is about 045% in the general population2 Sialolithiasis accounts for about 50% of all disease occurring in major salivary glands, and for about 66% of all obstructive salivary gland diseases Salivary gland stones are twice as common in males as in females The most common age range in which they occur is between 30 and 60, and they are uncommon in children2


  1. ^ a b c d e f Neville BW, Damm DD, Allen CA, Bouquot JE 2002 Oral & maxillofacial pathology 2nd ed Philadelphia: WB Saunders pp 393–395 ISBN 0721690033 
  2. ^ a b c d e f g h i j k l m Capaccio, P; Torretta, S; Ottavian, F; Sambataro, G; Pignataro, L August 2007 "Modern management of obstructive salivary diseases" Acta Otorhinolaryngologica Italica 27 4: 161–72 PMC 2640028  PMID 17957846 
  3. ^ a b c d e f g h i j k l m n o p q Hupp JR, Ellis E, Tucker MR 2008 Contemporary oral and maxillofacial surgery 5th ed St Louis, Mo: Mosby Elsevier pp 398, 407–409 ISBN 9780323049030 
  4. ^ a b c Rice, DH February 1984 "Advances in diagnosis and management of salivary gland diseases" The Western journal of medicine 140 2: 238–49 PMC 1021605  PMID 6328773 
  5. ^ "UOTW #70 - Ultrasound of the Week" Ultrasound of the Week 24 April 2016 Retrieved 27 May 2017 
  6. ^ 1 – Overview of stones by the National Institutes of Health US

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