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Schwannoma

schwan noma, schwannomas tumors
A schwannoma is a benign nerve sheath tumor composed of Schwann cells, which normally produce the insulating myelin sheath covering peripheral nerves

Contents

  • 1 Overview
  • 2 Additional images
  • 3 See also
  • 4 References

Overviewedit

Schwannomas are homogeneous tumors, consisting only of Schwann cells The tumor cells always stay on the outside of the nerve, but the tumor itself may either push the nerve aside and/or up against a bony structure thereby possibly causing damage Schwannomas are relatively slow-growing For reasons not yet understood, schwannomas are mostly benign and less than 1% become malignant, degenerating into a form of cancer known as neurofibrosarcoma These masses are generally contained within a capsule, and so surgical removal is often successful3

Schwannomas can be associated with neurofibromatosis type II, which may be due to a loss-of-function mutation in the protein merlin4 They are universally S-100 positive, which is a marker for cells of neural crest cell origin

Schwannomas of the head and neck are a fairly common occurrence and can be found incidentally in 3–4% of patients at autopsy4 Most common of these is a vestibular schwannoma, a tumor of the vestibulocochlear nerve that may lead to tinnitus and hearing loss on the affected side Outside the cranial nerves, schwannomas may present on the flexor surfaces of the limbs Rare occurrences of these tumors in the penis have been documented in the literature5

Verocay bodies are seen histologically in schwannomas

Additional imagesedit

See alsoedit

  • Intranodal palisaded myofibroblastoma
  • List of inclusion bodies that aid in diagnosis of cutaneous conditions
  • Neurofibroma

Referencesedit

  1. ^ James, William; Berger, Timothy; Elston, Dirk 2005 Andrews' Diseases of the Skin: Clinical Dermatology 10th ed Saunders ISBN 0-7216-2921-0
  2. ^ a b c Rapini, Ronald P; Bolognia, Jean L; Jorizzo, Joseph L 2007 Dermatology: 2-Volume Set St Louis: Mosby ISBN 1-4160-2999-0 
  3. ^ Biswas, Deb September 2007 "Extracranial head and neck schwannomas—A 10-year review" Auris Nasus Larynx 34 3: 353–359 doi:101016/janl200701006 
  4. ^ a b Hanemann, CO December 2006 "News on the genetics, epidemiology, medical care and translational research of Schwannomas" Journal of Neurology 253 12: 1533–1541 PMID 17219030 doi:101007/s00415-006-0347-0 
  5. ^ Nguyen, Austin Huy; Smith, Megan; Maranda, Eric; Punnen, Sanoj 24 December 2015 "Clinical Features and Treatment of Penile Schwannoma: A Systematic Review" Clinical Genitourinary Cancer 14: 198–202 doi:101016/jclgc201512018 

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Schwannoma Information about

Schwannoma


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    Schwannoma beatiful post thanks!

    29.10.2014


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