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Sarcoma botryoides

sarcoma botryoides, sarcoma botryoides images
Sarcoma botryoides or botryoid sarcoma1 or botryoid rhabdomyosarcoma is a subtype of embryonal rhabdomyosarcoma, that can be observed in the walls of hollow, mucosa lined structures such as the nasopharynx, common bile duct, urinary bladder of infants and young children or the vagina in females, typically younger than age 8 The name comes from the gross appearance of "grape bunches" botryoid in Greek


  • 1 Histology
  • 2 Clinical characteristics
  • 3 Epidemiology
  • 4 Treatment and prognosis
  • 5 References
  • 6 External links


Under the microscope one can see rhabdomyoblasts that may contain cross-striations Tumor cells are crowded in a distinct layer beneath the vaginal epithelium cambium layer

Spindle-shaped tumor cells that are desmin positive

Clinical characteristicsedit

For botryoid rhabdomyosarcoma of the vagina, the most common clinical finding is vaginal bleeding2 but vaginal bleeding is not specific for sarcoma botryoides: other vaginal cancers are possible They may appear as a polypoid mass, somewhat yellow in color and are friable: thus, they possibly may break off, leading to vaginal bleeding or infections


Sarcoma botryoides normally is found in children under 8 years of age Onset of symptoms occurs at age 3 years 383 months on average3 Cases of older women with this condition have also been reported4

Treatment and prognosisedit

The disease used to be uniformly fatal, with a 5-year survival rate between 10 and 35%5 As a result, treatment was radical surgery New multidrug chemotherapy regimens with or without radiation therapy are now used in combination with less radical surgery with good results, although outcome data are not yet available6


  1. ^ "botryoid sarcoma" at Dorland's Medical Dictionary
  2. ^ Rahaman, J and Cohen, CJ Gynecologic Sarcomas in Holland-Frei Cancer Medicine - 6th Ed Kufe, DW et al editors BC Decker Inc, Hamilton, Ontario, 2003
  3. ^ Hilgers R 1975 "Pelvic exenteration for vaginal embryonal rhabdomyosarcoma: a review" Obstet Gynecol 45 2: 175–80 PMID 1090863 
  4. ^ Reynolds E, Logani S, Moller K, Horowitz I 2006 "Embryonal rhabdomyosarcoma of the uterus in a postmenopausal woman Case report and review of the literature" Gynecol Oncol 103 2: 736–9 PMID 16684558 doi:101016/jygyno200603033 
  5. ^ Piver M, Rose P 1988 "Long-term follow-up and complications of infants with vulvovaginal embryonal rhabdomyosarcoma treated with surgery, radiation therapy, and chemotherapy" Obstet Gynecol 71 3 Pt 2: 435–7 PMID 3347430 
  6. ^ Rotmensch, J and Yamada, SD Neoplasms of the Vulva and Vagina in Holland-Frei Cancer Medicine - 6th Ed Kufe, DW et al editors BC Decker Inc, Hamilton, Ontario, 2003

External linksedit

  • humpathcom #12369

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Sarcoma botryoides

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