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Retapamulin

retapamulin ointment, retapamulin
Retapamulin is a topical antibiotic developed by GlaxoSmithKline It is the first drug in the new class of pleuromutilin antibiotics to be approved for human use It is marketed as an ointment under the brand names Altabax and Altargo

Retapamulin was approved by the United States Food and Drug Administration in April 2007 for the treatment of bacterial skin infections such as impetigo In May 2007, retapamulin received approval in the EU from the European Medicines Agency for the same indication

Clinical trials have demonstrated its efficacy against certain Gram-positive bacteria including MRSA

Contents

  • 1 Indications
  • 2 Pharmacology
    • 21 Mechanism of action
    • 22 Pharmakinetics
  • 3 Contraindications
  • 4 Adverse reactions
  • 5 References

Indications

Retapamulin is indicated for the topical treatment of impetigo due to Staphylococcus aureus methicillin-susceptible only or Streptococcus pyogenes

Pharmacology

Mechanism of action

Retapamulin is an antibacterial agent, specifically a protein synthesis inhibitor The medication selectively inhibits bacterial protein synthesis by interacting at a site on the 50S subunit of the bacterial ribosome through an interaction that differs from other antibiotics

Pharmakinetics

Systemic exposure following topical application through intact skin is low

Contraindications

None yet reported

Adverse reactions

The most common reported adverse reaction was irritation at the application site

References

  1. ^ Jones R, Fritsche T, Sader H, Ross J 2006 "Activity of retapamulin SB-275833, a novel pleuromutilin, against selected resistant gram-positive cocci" Antimicrob Agents Chemother 50 7: 2583–6 doi:101128/AAC01432-05 PMC 1489758  PMID 16801451 
  2. ^ a b c d e Borrza, S; Philippi, E, eds 2007 Physicians' Desk Reference 62nd ed pp 1318–20 ISBN 1-56363-660-3 

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Retapamulin Information about

Retapamulin


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    29.10.2014


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