Thu . 19 Apr 2019


retapamulin ointment, retapamulin
Retapamulin is a topical antibiotic developed by GlaxoSmithKline It is the first drug in the new class of pleuromutilin antibiotics to be approved for human use It is marketed as an ointment under the brand names Altabax and Altargo

Retapamulin was approved by the United States Food and Drug Administration in April 2007 for the treatment of bacterial skin infections such as impetigo In May 2007, retapamulin received approval in the EU from the European Medicines Agency for the same indication

Clinical trials have demonstrated its efficacy against certain Gram-positive bacteria including MRSA


  • 1 Indications
  • 2 Pharmacology
    • 21 Mechanism of action
    • 22 Pharmakinetics
  • 3 Contraindications
  • 4 Adverse reactions
  • 5 References


Retapamulin is indicated for the topical treatment of impetigo due to Staphylococcus aureus methicillin-susceptible only or Streptococcus pyogenes


Mechanism of action

Retapamulin is an antibacterial agent, specifically a protein synthesis inhibitor The medication selectively inhibits bacterial protein synthesis by interacting at a site on the 50S subunit of the bacterial ribosome through an interaction that differs from other antibiotics


Systemic exposure following topical application through intact skin is low


None yet reported

Adverse reactions

The most common reported adverse reaction was irritation at the application site


  1. ^ Jones R, Fritsche T, Sader H, Ross J 2006 "Activity of retapamulin SB-275833, a novel pleuromutilin, against selected resistant gram-positive cocci" Antimicrob Agents Chemother 50 7: 2583–6 doi:101128/AAC01432-05 PMC 1489758  PMID 16801451 
  2. ^ a b c d e Borrza, S; Philippi, E, eds 2007 Physicians' Desk Reference 62nd ed pp 1318–20 ISBN 1-56363-660-3 

retapamulin, retapamulin 1%, retapamulin and mupirocin, retapamulin cream, retapamulin impetigo, retapamulin impurity, retapamulin mechanism of action, retapamulin ointment, retapamulin pronunciation, retapamulin topical

Retapamulin Information about


  • user icon

    Retapamulin beatiful post thanks!


Retapamulin viewing the topic.
Retapamulin what, Retapamulin who, Retapamulin explanation

There are excerpts from wikipedia on this article and video

Random Posts

Body politic

Body politic

The body politic is a metaphor that regards a nation as a corporate entity,2 likened to a human body...


Kakamega is a town in western Kenya lying about 30 km north of the Equator It is the headquarte...
Academic year

Academic year

An academic year is a period of time which schools, colleges and universities use to measure a quant...
Lucrezia Borgia

Lucrezia Borgia

Lucrezia Borgia Italian pronunciation: luˈkrɛttsja ˈbɔrdʒa; Valencian: Lucrècia Borja luˈkrɛsia...