Retapamulinretapamulin ointment, retapamulin
Retapamulin is a topical antibiotic developed by GlaxoSmithKline It is the first drug in the new class of pleuromutilin antibiotics to be approved for human use It is marketed as an ointment under the brand names Altabax and Altargo
Retapamulin was approved by the United States Food and Drug Administration in April 2007 for the treatment of bacterial skin infections such as impetigo In May 2007, retapamulin received approval in the EU from the European Medicines Agency for the same indication
Clinical trials have demonstrated its efficacy against certain Gram-positive bacteria including MRSA
- 1 Indications
- 2 Pharmacology
- 21 Mechanism of action
- 22 Pharmakinetics
- 3 Contraindications
- 4 Adverse reactions
- 5 References
Retapamulin is indicated for the topical treatment of impetigo due to Staphylococcus aureus methicillin-susceptible only or Streptococcus pyogenes
Mechanism of action
Retapamulin is an antibacterial agent, specifically a protein synthesis inhibitor The medication selectively inhibits bacterial protein synthesis by interacting at a site on the 50S subunit of the bacterial ribosome through an interaction that differs from other antibiotics
Systemic exposure following topical application through intact skin is low
None yet reported
The most common reported adverse reaction was irritation at the application site
- ^ Jones R, Fritsche T, Sader H, Ross J 2006 "Activity of retapamulin SB-275833, a novel pleuromutilin, against selected resistant gram-positive cocci" Antimicrob Agents Chemother 50 7: 2583–6 doi:101128/AAC01432-05 PMC 1489758 PMID 16801451
- ^ a b c d e Borrza, S; Philippi, E, eds 2007 Physicians' Desk Reference 62nd ed pp 1318–20 ISBN 1-56363-660-3
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