Ramoplaninramoplanin clinical trial, ramoplanin oscient
Ramoplanin INN is a glycolipodepsipeptide antibiotic drug derived from strain ATCC 33076 of Actinoplanes
It exerts its bacteriocidal effect by inhibiting cell wall biosynthesis, acting by inhibiting the transglycosylation step of peptidoglycan synthesis
Its development has been fast-tracked by the US Food and Drug Administration as a treatment for multiple antibiotic-resistant Clostridium difficile infection of the gastrointestinal tract, Unlike Vancomycin, it is absorbed in the gastrointestinal tract, although it is unstable in the bloodstream, so can be taken only orally against Clostridium difficile infections of the gastrointestinal tract
- ^ Farver DK, Hedge DD, Lee SC Ramoplanin: a lipoglycodepsipeptide antibiotic Annals of Pharmacotherapy 2005 May;395:863-8 PMID 15784805
- ^ Fang X, Tiyanont K, Zhang Y, Wanner J, Boger D, Walker S The mechanism of action of ramoplanin and enduracidin Molecular Biosystems 2006 Jan;21:69-76 PMID 16880924
- ^ Fulco P, Wenzel RP Ramoplanin: a topical lipoglycodepsipeptide antibacterial agent Expert Review of Anti Infective Therapy 2006 Dec;46:939-45 PMID 17181409
- ^ Scheinfeld N A comparison of available and investigational antibiotics for complicated skin infections and treatment-resistant Staphylococcus aureus and enterococcus Journal of Drugs in Dermatology 2007 Jan;61:97-103 PMID 17373167
- ^ Balagopal A, Sears CL Clostridium difficile: new therapeutic options Current Opinion in Pharmacology 2007 Oct;75:455-8 PMID 17644040
- ^ Gerding DN, Muto CA, Owens RC Jr Treatment of Clostridium difficile infection Clinical Infectious Diseases 2008 Jan 15;46 Suppl 1:S32-42 PMID 18177219
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