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pseudohypoaldosteronism, pseudohyperaldosteronism symptoms
Pseudohyperaldosteronism also pseudoaldosteronism is a medical condition that mimics hyperaldosteronism Like hyperaldosteronism, it produces hypertension associated with low plasma renin activity, and metabolic alkalosis associated with hypokalemia Unlike hyperaldosteronism, it involves aldosterone levels that are normal or low hypoaldosteronism


  • 1 Presentation
  • 2 Causes
  • 3 Diagnosis
  • 4 Treatment
  • 5 See also
  • 6 References
  • 7 External links


This condition is characterized by hypertension, kaliuresis and reduced plasma renin


This condition has several known causes, dietary and genetic Dietary causes include the chronic excessive ingestion of licorice Licorice inhibits the 11-beta hydroxysteroid dehydrogenase type II Protein:HSD11B2 enzyme resulting in inappropriate stimulation of the mineralocorticoid receptor by cortisol

Genetic causes include Liddle's syndrome



See also

  • Apparent mineralocorticoid excess syndrome
  • Pseudohypoaldosteronism


  1. ^ Armanini D, Calò L, Semplicini A June 2003 "Pseudohyperaldosteronism: pathogenetic mechanisms" Crit Rev Clin Lab Sci 40 3: 295–335 doi:101080/713609355 PMID 12892318 
  2. ^ Sigurjonsdottir HA, Axelson M, Johannsson G, Manhem K, Nyström E, Wallerstedt S 2006 "The liquorice effect on the RAAS differs between the genders" Blood Press 15 3: 169–72 doi:101080/08037050600593060 PMID 16864159 
  3. ^ Takeuchi K, Abe K, Sato M, et al February 1989 "Plasma aldosterone level in a female case of pseudohyperaldosteronism Liddle's syndrome" Endocrinol Jpn 36 1: 167–73 doi:101507/endocrj195436167 PMID 2659310 

External links

Classification V · T · D
  • ICD-10: I151
  • OMIM: 177200
  • MeSH: D056929
  • DiseasesDB: 7471
External resources
  • Orphanet: 526

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Pseudohyperaldosteronism Information about


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