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properdin deficiency, properdin
1W0R, 1W0S

IdentifiersAliasesCFP, BFD, PFC, PFD, PROPERDIN, complement factor properdin, ProperdinExternal IDsMGI: 97545 HomoloGene: 1969 GeneCards: CFP
Gene location Human
ChrX chromosome human[1]
BandXp1123Start47,623,172 bp[1]
End47,630,305 bp[1]
RefSeq mRNA



RefSeq protein



Location UCSCChr X: 4762 – 4763 MbChr X: 2093 – 2093 MbPubMed search[3][4]Wikidata
The alternative pathway is not dependent on antibodies This branch of the complement system is activated by IgA immune complexes and bacterial endotoxins, polysaccharides, and cell walls, and results in producing anaphylatoxins, opsonins, chemotactic factors, and the membrane attack complex, all of which help fight pathogens


Properdin was discovered in 1954 by Dr Louis Pillemer of the Institute of Pathology now the Department of Pathology at Case Western Reserve University


Properdin deficiency is a rare X-linked disease in which properdin is deficient Affected individuals are susceptible to fulminant meningococcal disease[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126759 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001128 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:" 
  4. ^ "Mouse PubMed Reference:" 
  5. ^ Smith C, Pangburn M, Vogel CW, Müller-Eberhard H 1984 "Molecular Architecture of Human Properdin, a Positive Regulator of the Alternative Pathway of Complement" J Biol Chem 259: R4582–4588 
  6. ^ Hourcade D 2006 "The Role of Properdin in the Assembly of the Alternative Pathway C3 Convertases of Complement" J Biol Chem 281: R2128–2132 doi:101074/jbcm508928200 
  7. ^ Dr Lars Otto Uttenthal Properdin September 01 2005 Archived 2012-04-02 at the Wayback Machine

External links

  • Properdin at the US National Library of Medicine Medical Subject Headings MeSH

properdin, properdin complement, properdin deficiency, properdin dependent opsonization, properdin function, properdin iodine, properdin pathway, properdin pronunciation, properdin protein, properdin system

Properdin Information about


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    Properdin beatiful post thanks!


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Properdin what, Properdin who, Properdin explanation

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