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Potocytosis

potocytosis
Potocytosis is a type of receptor-mediated endocytosis in which small molecules are transported across the plasma membrane of a cell The molecules are transported by caveolae rather than clathrin-coated vesicles and are deposited directly into the cytosol

Like other types of receptor-mediated endocytosis, potocytosis typically begins when an extracellular ligand binds to a receptor protein on the surface of a cell, thus beginning the formation of an endocytotic vesicle The ligand is usually of low molecular mass eg vitamins, but some larger molecules such as lipids can also act as ligands

Mechanism

Lipid rafts in the plasma membrane act as membrane microdomains They are enriched in cholesterol and sphingolipids and are involved potocytosis as the lateral compartmentalization of molecules Caveolae are caveolin-1-enriched smooth invaginations found on these lipid rafts that contribute to transportation of molecules Potocytosis works by taking up material into caveolae at the surface of the cell Glycosylphosphatidylinositol-anchored class of membrane proteins generate high concentrations of molecules This may either be by releasing a receptor bound molecule, by converting molecules enzymatically or by releasing them from a carrier protein

References

  1. ^ a b Widmaier, Eric P; Hershel Raff; Kevin T Strang 2008 Vander's Human Physiology, 11th Ed McGraw-Hill p 114 ISBN 978-0-07-304962-5 
  2. ^ Mineo, C; Anderson, RG August 2001 "Potocytosis Robert Feulgen Lecture" Histochem Cell Biology 116 2: 109–18 doi:101007/s004180100289 PMID 11685539 
  3. ^ Lajoie, Patrick; Nabi, Ivan R 2010 "Lipid rafts, caveolae, and their endocytosis" International Review of Cell and Molecular Biology 282: 135–163 doi:101016/S1937-64481082003-9 ISSN 1937-6448 PMID 20630468 
  4. ^ Anderson, R G March 1993 "Potocytosis of small molecules and ions by caveolae" Trends in Cell Biology 3 3: 69–72 ISSN 0962-8924 PMID 14731772 

potocytosis


Potocytosis Information about

Potocytosis


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    Potocytosis beatiful post thanks!

    29.10.2014


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