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Philip Ingham

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Philip William Ingham FRS, FMedSci, Hon FRCP born 19 March 1955 Liverpool is a British geneticist, currently Director of the Living Systems Institute at the University of Exeter, UK[1] Previously, he was Vice Dean, Research and Toh Kian Chui Distinguished Professor at the Lee Kong Chian School of Medicine,[2] a partnership between Nanyang Technological University, Singapore and Imperial College, London

Contents

  • 1 Career
  • 2 Scientific Contributions
  • 3 Publications
  • 4 References
  • 5 External links

Career

Ingham was educated at Merchant Taylors' School, Crosby[3] near Liverpool and then at Queens' College in the University of Cambridge[citation needed] where after initially reading Philosophy and Theology he graduated in Genetics He gained his Doctorate of Philosophy from the University of Sussex under the supervision of J Robert S Whittle[4] before moving to the Laboratoire de Génétique Moleculaire des Eukaryotes in Strasbourg, France, as a Royal Society European Exchange Programme fellow He returned to the UK in 1982, joining the Imperial Cancer Research Fund ICRF, now known as Cancer Research UK as a post-doctoral research fellow in the laboratory of David Ish-Horowicz After a brief spell as a Research Scientist at the MRC Laboratory of Molecular Biology in Cambridge,[5] he re-joined the ICRF as a staff scientist, remaining there for ten years before moving to the University of Sheffield, where he established the MRC Centre for Developmental and Biomedical Genetics[6] He was elected a member of the European Molecular Biology Organization in 1995,[7] a Fellow of the Academy of Medical Sciences in 2001 and Fellow of the Royal Society in 2002[8] In 2005 he became the second recipient of the Medal of the Genetics Society of Great Britain[9] and in 2007 was elected an Honorary Fellow of the Royal College of Physicians He has served on numerous international Scientific Advisory Boards and funding committees and is currently President of the International Society of Developmental Biologists In 2014 he was awarded the Waddington Medal by the British Society for Developmental Biology[10] He has lived and worked in Singapore since 2005

Scientific Contributions

As a graduate student, Ingham isolated a novel homoeotic mutation in Drosophila, which he named trithorax trx[11] Using genetic mosaic analysis, he showed that the trx gene is required for the maintenance of the determined state of cells,[12] presaging the current understanding of the Trithorax-group proteins as key epigenetic regulators throughout the animal kingdom Subsequently, he pioneered the molecular analysis of the process of segmentation in the Drosophila embryo, through the simultaneous analysis the expression of patterns of pair rule genes using the technique of in situ hybridisation[13] These studies led to his interest in what is now known as the Hedgehog signalling pathway; Ingham's genetic studies identified the core components of this pathway[14] and in particular the role of the Patched protein as the receptor for the Hedgehog ligand[15] In 1993, in collaboration with Andy McMahon and Cliff Tabin, Ingham's research group discovered the vertebrate homologues of the Drosophila hedgehog gene, including Sonic hedgehog[16] This finding set in train a surge of interest in this pathway, leading amongst other things, to the recognition of its role in a number of human cancers and to the development of a novel anti-cancer drug that specifically targets the pathway[17] Ingham was in the vanguard of researchers to adopt the zebrafish, Danio rerio, as a model for the analysis of vertebrate development and more recently for the study of processes related to human diseases

Publications

Ingham has authored or co-authored over 170 peer-reviewed scientific primary research papers and review articles Notable amongst the latter are his 1988 review of the Molecular Genetics of embryonic Pattern formation in Drosophila[18] and his 2001 review, co-authored with Andy McMahon, on the Principles and Paradigms of Hedgehog signalling[19]

References

  1. ^ https://wwwexeteracuk/livingsystems/
  2. ^ "Archived copy" Archived from the original on 15 June 2014 Retrieved 15 June 2014 
  3. ^ › Alumni Career Profiles › Philip Ingham 1973 Leaver – Professor of Developmental Biology Archived 21 November 2015 at the Wayback Machine
  4. ^ List of University of Sussex alumni – Wikipedia, the free encyclopedia
  5. ^ Alumni | MRC Laboratory of Molecular Biology
  6. ^ Our History | The Bateson Centre Archived 8 June 2014 at Archiveis
  7. ^ "EMBO members elected 1995" EMBO J 14 13: 3288 PMC 394391  
  8. ^ http://wwwthe-scientistcom/articlesview/articleNo/21247/title/2002-Royal-Society-Fellows/
  9. ^ Genetics Society Website > Prizes > Genetics Society Medal 2005
  10. ^ An interview with Phil Ingham
  11. ^ Ingham, Philip & Robert Whittle 1980 "Trithorax: a new homoeotic mutation of Drosophila melanogaster causing transformations of abdominal and thoracic imaginal segments" Molecular and General Genetics 179 3: 607–614 doi:101007/bf00271751 
  12. ^ Ingham, PW 1985 "A clonal analysis of the requirement for the trithorax gene in the diversification of segments in Drosophila" Journal of Embryology and Experimental Morphology 89: 349 
  13. ^ Howard, K & Ingham, P 1986 "Regulatory interactions between the segmentation genes fushi tarazu, hairy, and engrailed in the Drosophila blastoderm" Cell 44 6: 949–957 doi:101016/0092-86748690018-8 
  14. ^ Forbes, AJ; Nakano, Y; Taylor, AM & Ingham, PW 1993 "Genetic analysis of hedgehog signalling in the Drosophila embryo" Development 119: 115 
  15. ^ Ingham, PW; Taylor, AM & Nakano, Y "Role of the Drosophila patched gene in positional signalling" 184–187 
  16. ^ Biologists Find Key Genes That Shape Patterning of Embryos – New York Times
  17. ^ Pin by Cancer Research UK on Skin Cancer | Pinterest
  18. ^ Ingham PW 1988 "The molecular genetics of embryonic pattern formation in Drosophila" Nature 335 6185: 25–34 doi:101038/335025a0 
  19. ^ Ingham PW, McMahon AP 2001 "Hedgehog signaling in animal development: paradigms and principles" Genes & Development 15 23: 3059–87 doi:101101/gad938601 PMID 11731473 

External links

  • Ncbinlmnihgov
  • Scienceblogcancerresearchukorg

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