Pemphigus vulgarispemphigus vulgaris, pemphigus vulgaris pictures
Pemphigus vulgaris is a rare chronic blistering skin disease and the most common form of pemphigus It is classified as a type II hypersensitivity reaction in which antibodies are formed against desmosomes, components of the skin that function to keep certain layers of skin bound to each other As desmosomes are attacked, the layers of skin separate and the clinical picture resembles a blister Over time the condition inevitably progresses without treatment: lesions increase in size and distribution throughout the body, behaving physiologically like a severe burn
Before the advent of modern treatments, mortality for the disease was close to 90% Today, the mortality rate with treatment is between 5-15%
- 1 Signs and symptoms
- 2 Pathophysiology
- 3 Diagnosis
- 4 Treatment
- 5 Research
- 6 See also
- 7 References
- 8 External links
Signs and symptomsedit
Pemphigus vulgaris most commonly presents with oral blisters buccal and palatine mucosa, especially, but also includes cutaneous blisters Other mucosal surfaces, the conjunctiva, nose, esophagus, penis, vulva, vagina, cervix, and anus, may also be affected Flaccid blisters over the skin are frequently seen with sparing of the skin covering the palms and soles1
Blisters commonly erode and leave ulcerated lesions and erosions A positive Nikolsky sign induction of blistering in normal skin or at the edge of a blister is indicative of the disease 1
Severe pain with chewing can lead to weight loss and malnutrition1
Pemphigus is an autoimmune disease caused by antibodies directed against both desmoglein 1 and desmoglein 3 present in desmosomes Loss of desmosomes results in loss of cohesion between keratinocytes in the epidermis, and a disruption of the barrier function served by intact skin The process is classified as a type II hypersensitivity reaction in which antibodies bind to antigens on the body's own tissues On histology, the basal keratinocytes are usually still attached to the basement membrane leading to a characteristic appearance called "tombstoning" Transudative fluid accumulates in between the keratinocytes and the basal layer suprabasal split, forming a blister and resulting in what is known as a positive Nikolsky's sign This is a contrasting feature from bullous pemphigoid, which is thought to be due to anti-hemidesmosome antibodies, and where the detachment occurs between the epidermis and dermis subepidermal bullae Clinically, pemphigus vulgaris is characterized by extensive flaccid blisters and mucocutaneous erosions The severity of the disease, as well as the mucosal lesions, is believed to be directly proportional to the levels of desmoglein 3 Milder forms of pemphigus like foliacious and erythematoses are more anti-desmoglein 1 heavy
The disease arises most often in middle-aged or older people, usually starting with a blister that ruptures easily It can also start with blisters in the mouth The lesions can become quite extensive
Because it is a rare disease, diagnosis is often complicated and takes a long time Early in the disease patients may have erosions in the mouth or blisters on the skin These blisters can be itchy or painful Theoretically, the blisters should demonstrate a positive Nikolsky's sign, in which the skin sloughs off from slight rubbing, but this is not always reliable The gold standard for diagnosis is a punch biopsy from the area around the lesion that is examined by direct immunofluorescent staining, in which cells are acantholytic, that is, lacking the normal intercellular connections that hold them together These can also be seen on a Tzanck smear These cells are basically rounded, nucleated keratinocytes formed due to antibody mediated damage to cell adhesion protein desmoglein
Pemphigus vulgaris is easily confused with impetigo and candidiasis IgG4 is considered pathogenic The diagnosis can be confirmed by testing for the infections that cause these other conditions, and by a lack of response to antibiotic treatment2
Corticosteroids and other immunosuppressive medications have historically been employed to reduce pemphigus symptoms, yet steroids are associated with serious and long-lasting side effects and their use should be limited as much as possible Intravenous immunoglobulin, mycophenolate mofetil, methotrexate, azathioprine, and cyclophosphamide have also been used with varying degrees of success
An established alternative to steroids are monoclonal antibodies such as rituximab, which are increasingly being used as first-line treatment In numerous case series, many patients achieve remission after one cycle of rituximab Treatment is more successful if initiated early on in the course of disease, perhaps even at diagnosis Rituximab treatment combined with monthly IV immune globulin infusion has resulted in long-term remission with no recurrence of disease in 10 years after treatment was halted3 This was a small trial study of 11 patients with 10 patients followed to completion
Research into using genetically modified T-cells to treat pemphigus vulgaris in mice was reported in 201645 Rituximab indiscriminately attacks all B cells, which reduces the body's ability to control infections In the experimental treatment, human T cells are genetically engineered to recognize only those B cells that produce antibodies to desmoglein 3
- List of conditions caused by problems with junctional proteins
- List of cutaneous conditions
- List of immunofluorescence findings for autoimmune bullous conditions
- ^ a b c "Pathogenesis, clinical manifestations, and diagnosis of pemphigus" wwwuptodatecom Retrieved 2017-04-03
- ^ Kaplan DL 2009 "Dermclinic" Consultant 49 3
- ^ Ahmed, A Razzaque; Kaveri, Srini; Spigelman, Zachary December 31, 2015 "Long-Term Remissions in Recalcitrant Pemphigus Vulgaris" The New England Journal of Medicine 373: 2693–2694 doi:101056/NEJMc1508234
- ^ Gallagher, James 2016-07-01 "'Civil war' in immune system can fight disease" BBC News, Health Retrieved 2016-07-01
- ^ Ellebrecht, Christoph T; Bhoj, Vijay G; Nace, Arben; Choi, Eun Jung; Mao, Xuming; Cho, Michael Jeffrey; Zenzo, Giovanni Di; Lanzavecchia, Antonio; Seykora, John T 2016-06-30 "Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease" Science 353: aaf6756 ISSN 0036-8075 PMID 27365313 doi:101126/scienceaaf6756
- International Pemphigus Pemphigoid Foundation
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