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PDPN, pdpn neuropathy
3WSR, 4YO0

Identifiers Aliases PDPN, AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA226, T1A, T1A-2, T1A2, TI1A, podoplanin External IDs MGI: 103098 HomoloGene: 4729 GeneCards: PDPN RNA expression pattern

More reference expression data Orthologs Species Human Mouse Entrez
RefSeq mRNA



RefSeq protein



Location UCSC Chr 1: 1358 – 1362 Mb Chr 4: 14327 – 1433 Mb PubMed search 1 2 Wikidata
^ "Mouse PubMed Reference:" 
  • ^ Zimmer G, Oeffner F, Von Messling V, Tschernig T, Groness HJ, Klenk HD, Herrler G Sep 1999 "Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium" Biochem J 341 Pt 2: 277–84 PMC 1220357  PMID 10393083 doi:101042/0264-6021:3410277 
  • ^ Ma T, Yang B, Matthay MA, Verkman AS Jul 1998 "Evidence against a role of mouse, rat, and two cloned human t1alpha isoforms as a water channel or a regulator of aquaporin-type water channels" Am J Respir Cell Mol Biol 19 1: 143–9 PMID 9651190 doi:101165/ajrcmb1912953 
  • ^ a b "Entrez Gene: PDPN podoplanin" 
  • ^ a b c d Astarita, JL; Acton, SE; Turley, SJ 2012 "Podoplanin: emerging functions in development, the immune system, and cancer" Frontiers in immunology 3: 283 PMC 3439854  PMID 22988448 doi:103389/fimmu201200283 
  • ^ a b Fu J, Gerhardt H, McDaniel JM, Xia B, Liu X, Ivanciu L, Ny A, Hermans K, Silasi-Mansat R, McGee S, Nye E, Ju T, Ramirez MI, Carmeliet P, Cummings RD, Lupu F, Xia L November 2008 "Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice" J Clin Invest 118 11: 3725–37 PMC 2567837  PMID 18924607 doi:101172/JCI36077 
  • ^ Imaizumi Y, Amano I, Tsuruga E, Kojima H, Sawa Y October 2010 "Immunohistochemical examination for the distribution of podoplanin-expressing cells in developing mouse molar tooth germs" Acta Histochem Cytochem 43 5: 115–21 PMC 2965832  PMID 21060740 doi:101267/ahc10023 
  • ^ Herzog, BH; Fu, J; Wilson, SJ; Hess, PR; Sen, A; McDaniel, JM; Pan, Y; Sheng, M; Yago, T; Silasi-Mansat, R; McGee, S; May, F; Nieswandt, B; Morris, AJ; Lupu, F; Coughlin, SR; McEver, RP; Chen, H; Kahn, ML; Xia, L 3 October 2013 "Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2" Nature 502 7469: 105–9 PMC 3791160  PMID 23995678 doi:101038/nature12501 
  • ^ Kitano, H; Kageyama, S; Hewitt, SM; Hayashi, R; Doki, Y; Ozaki, Y; Fujino, S; Takikita, M; Kubo, H; Fukuoka, J October 2010 "Podoplanin expression in cancerous stroma induces lymphangiogenesis and predicts lymphatic spread and patient survival" Archives of pathology & laboratory medicine 134 10: 1520–7 PMID 20923309 doi:101043/2009-0114-OA1 
  • ^ Chuang, WY; Yeh, CJ; Chao, YK; Liu, YH; Chang, YS; Tseng, CK; Chang, HK; Wan, YL; Hsueh, C 2014 "Concordant podoplanin expression in cancer-associated fibroblasts and tumor cells is an adverse prognostic factor in esophageal squamous cell carcinoma" International Journal of Clinical and Experimental Pathology 7 8: 4847–56 PMC 4152045  PMID 25197355 
  • ^ Martín-Villar, E; Borda-d'Agua, B; Carrasco-Ramirez, P; Renart, J; Parsons, M; Quintanilla, M; Jones, GE 20 August 2015 "Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability" Oncogene 34 34: 4531–44 PMC 4430312  PMID 25486435 doi:101038/onc2014388 
  • Further readingedit

    • Wicki A, Christofori G 2007 "The potential role of podoplanin in tumour invasion" Br J Cancer 96 1: 1–5 PMC 2360213  PMID 17179989 doi:101038/sjbjc6603518 
    • Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al 1995 "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening" Genomics 23 1: 42–50 PMID 7829101 doi:101006/geno19941457 
    • Cross SH, Charlton JA, Nan X, Bird AP 1994 "Purification of CpG islands using a methylated DNA binding column" Nat Genet 6 3: 236–44 PMID 8012384 doi:101038/ng0394-236 
    • Bonaldo MF, Lennon G, Soares MB 1997 "Normalization and subtraction: two approaches to facilitate gene discovery" Genome Res 6 9: 791–806 PMID 8889548 doi:101101/gr69791 
    • Strausberg RL, Feingold EA, Grouse LH, et al 2003 "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" Proc Natl Acad Sci USA 99 26: 16899–903 PMC 139241  PMID 12477932 doi:101073/pnas242603899 
    • Kato Y, Fujita N, Kunita A, et al 2004 "Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors" J Biol Chem 278 51: 51599–605 PMID 14522983 doi:101074/jbcM309935200 
    • Kaneko M, Kato Y, Kunita A, et al 2004 "Functional sialylated O-glycan to platelet aggregation on Aggrus T1alpha/Podoplanin molecules expressed in Chinese hamster ovary cells" J Biol Chem 279 37: 38838–43 PMID 15231832 doi:101074/jbcM407210200 
    • Gerhard DS, Wagner L, Feingold EA, et al 2004 "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection MGC" Genome Res 14 10B: 2121–7 PMC 528928  PMID 15489334 doi:101101/gr2596504 
    • Martín-Villar E, Scholl FG, Gamallo C, et al 2005 "Characterization of human PA226 antigen T1alpha-2, podoplanin, a small membrane mucin induced in oral squamous cell carcinomas" Int J Cancer 113 6: 899–910 PMID 15515019 doi:101002/ijc20656 
    • Schacht V, Dadras SS, Johnson LA, et al 2005 "Up-Regulation of the Lymphatic Marker Podoplanin, a Mucin-Type Transmembrane Glycoprotein, in Human Squamous Cell Carcinomas and Germ Cell Tumors" Am J Pathol 166 3: 913–21 PMC 1602360  PMID 15743802 doi:101016/S0002-94401062311-5 
    • Otsuki T, Ota T, Nishikawa T, et al 2007 "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries" DNA Res 12 2: 117–26 PMID 16303743 doi:101093/dnares/122117 
    • Hultgård-Ekwall AK, Mayerl C, Rubin K, et al 2006 "An Interstitial Network of Podoplanin-Expressing Cells in the Human Endolymphatic Duct" J Assoc Res Otolaryngol 7 1: 38–47 PMC 2504586  PMID 16408168 doi:101007/s10162-005-0021-8 
    • Dumoff KL, Chu CS, Harris EE, et al 2006 "Low podoplanin expression in pretreatment biopsy material predicts poor prognosis in advanced-stage squamous cell carcinoma of the uterine cervix treated by primary radiation" Mod Pathol 19 5: 708–16 PMID 16528371 doi:101038/modpathol3800580 
    • Omachi T, Kawai Y, Mizuno R, et al 2007 "Immunohistochemical demonstration of proliferating lymphatic vessels in colorectal carcinoma and its clinicopathological significance" Cancer Lett 246 1–2: 167–72 PMID 16574316 doi:101016/jcanlet200602013 
    • Mishima K, Kato Y, Kaneko MK, et al 2007 "Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progression" Acta Neuropathol 111 5: 483–8 PMID 16596424 doi:101007/s00401-006-0063-y 
    • Wicki A, Lehembre F, Wick N, et al 2006 "Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton" Cancer Cell 9 4: 261–72 PMID 16616332 doi:101016/jccr200603010 
    • Gregory SG, Barlow KF, McLay KE, et al 2006 "The DNA sequence and biological annotation of human chromosome 1" Nature 441 7091: 315–21 PMID 16710414 doi:101038/nature04727 
    • Mishima K, Kato Y, Kaneko MK, et al 2007 "Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinoma" Acta Neuropathol 111 6: 563–8 PMID 16718353 doi:101007/s00401-006-0033-4 

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