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parvalbumin allergy, parvalbumin
Parvalbumin is a calcium-binding albumin protein with low molecular weight typically 9-11 kDa

It has three EF hand motifs and is structurally related to calmodulin and troponin C Parvalbumin is found in fast-contracting muscles, where its levels are highest, as well as in the brain and some endocrine tissues

Parvalbumin is a small, stable protein containing EF-hand type calcium binding sites It is involved in calcium signaling Typically, this protein is broken into three domains, domains AB, CD and EF, each individually containing a helix-loop-helix motif[3] The AB domain houses a two amino-acid deletion in the loop region, whereas domains CD and EF contain the N-terminal and C-terminal, respectively[3]

Calcium binding proteins like parvalbumin play a role in many physiological processes, namely cell-cycle regulation, second messenger production, muscle contraction, organization of microtubules and phototransduction[1] Alterations in the function of parvalbumin-expressing neurons have been implicated in various areas of clinical interest such as Alzheimer's disease,[4] age-related cognitive defects and some forms of cancer[3]


  • 1 Location and function
  • 2 Role in pathology
  • 3 References
  • 4 External links

Location and function

Pvalb is expressed in the reticular nucleus of the thalamus in the postnatal day 56 mouse Allen Brain Atlases In the cerebellum of adult mice Pvalb is expressed in Purkinje cells and molecular layer interneurons Allen Brain Atlases

Parvalbumin PV is present in GABAergic interneurons in the nervous system, especially the reticular thalamus,[5] and expressed predominantly by chandelier and basket cells in the cortex In the cerebellum, PV is expressed in Purkinje cells and molecular layer interneurons[6] In the hippocampus, PV+ interneurons are subdivided into basket, axo-axonic, bistratified, and oriens-lacunosum moleculare O-LM cells, each subtype targeting distinct domains of pyramidal cells[7]

PV interneurons' connections are mostly perisomatic around the cell body of neurons Most of the PV interneurons are fast-spiking They are also thought to give rise to gamma waves recorded in EEG

PV-expressing interneurons represent approximately 25% of GABAergic cells in the primate DLPFC[8][9] Other calcium-binding protein markers are calretinin most abundant subtype in DLPFC, about 50% and calbindin Interneurons are also divided into subgroups by the expression of neuropeptides such as somatostatin, neuropeptide Y, cholecystokinin

Role in pathology

Decreased PV and GAD67 expression was found in PV+ GABAergic interneurons in schizophrenia[10][11] PV has been identified as an allergen causing fish allergy[12]


  1. ^ a b Cates MS, Berry MB, Ho EL, Li Q, Potter JD, Phillips GN October 1999 "Metal-ion affinity and specificity in EF-hand proteins: coordination geometry and domain plasticity in parvalbumin" Structure 7 10: 1269–78 doi:101016/S0969-21260080060-X PMID 10545326 
  2. ^ Smargiassi, M T; Daghfous, G; Leroy, B; Legreneur, P; Toubeau, G; Bels, V; Wattiez, R 2012 Permyakov, Eugene A, ed "Chemical Basis of Prey Recognition in Thamnophiine Snakes: The Unexpected New Roles of Parvalbumins" PLoS ONE 7 6: e39560 doi:101371/journalpone0039560 PMC 3384659  PMID 22761824 
  3. ^ a b c Cates MS, Teodoro ML, Phillips GN March 2002 "Molecular mechanisms of calcium and magnesium binding to parvalbumin" Biophys J 82 3: 1133–46 doi:101016/S0006-34950275472-6 PMC 1301919  PMID 11867433 
  4. ^ Verret L, Mann EO, Hang GB, Barth AM, Cobos I, Ho K, Devidze N, Masliah E, Kreitzer AC, Mody I, Mucke L, Palop JJ 2012 "Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model" Cell 149 3: 708–21 doi:101016/jcell201202046 PMC 3375906  PMID 22541439 
  5. ^ Cowan, Ronald L; Wilson, Charles J; Emson, Piers C; Heizmann, Claus W 8 December 1990 "Parvalbumin-containing gabaergic interneurons in the rat neostriatum" The Journal of Comparative Neurology 302 2: 197–205 doi:101002/cne903020202 
  6. ^ Schwaller B, Meyer M, Schiffmann S 2002 "'New' functions for 'old' proteins: the role of the calcium-binding proteins calbindin D-28k, calretinin and parvalbumin, in cerebellar physiology Studies with knockout mice" Cerebellum 1 4: 241–58 doi:101080/147342202320883551 PMID 12879963 
  7. ^ Klausberger T, Marton LF, O'Neill J, Huck JH, Dalezios Y, Fuentealba P, Suen WY, Papp E, Kaneko T, Watanabe M, Csicsvari J, Somogyi P 2005 "Complementary roles of cholecystokinin- and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations" J Neurosci 25 42: 9782–93 doi:101523/JNEUROSCI3269-052005 PMID 16237182 free full text
  8. ^ Condé F, Lund JS, Jacobowitz DM, Baimbridge KG, Lewis DA 1994 "Local circuit neurons immunoreactive for calretinin, calbindin D-28k or parvalbumin in monkey prefrontal cortex: distribution and morphology" J Comp Neurol 341 1: 95–116 doi:101002/cne903410109 PMID 8006226 
  9. ^ Gabbott PL, Bacon SJ 1996 "Local circuit neurons in the medial prefrontal cortex areas 24a,b,c, 25 and 32 in the monkey: II Quantitative areal and laminar distributions" J Comp Neurol 364 4: 609–36 doi:101002/SICI1096-986119960122364:4<609::AID-CNE2>30CO;2-7 PMID 8821450 
  10. ^ Hashimoto T, Volk DW, Eggan SM, Mirnics K, Pierri JN, Sun Z, Sampson AR, Lewis DA 2003 "Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia" J Neurosci 23 15: 6315–26 PMID 12867516 
  11. ^ Nakazawa, K; Zsiros, V; Jiang, Z; Nakao, K; Kolata, S; Zhang, S; Belforte, JE 2011 "GABAergic interneuron origin of schizophrenia pathophysiology" Neuropharmacology 62 3: 1574–83 doi:101016/jneuropharm201101022 PMC 3090452  PMID 21277876 
  12. ^ Swoboda I, Bugajska-Schretter A, Verdino P, Keller W, Sperr WR, Valent P, Valenta R, Spitzauer S 2002 "Recombinant carp parvalbumin, the major cross-reactive fish allergen: a tool for diagnosis and therapy of fish allergy" J Immunol 168 9: 4576–84 doi:104049/jimmunol16894576 PMID 11971005 

External links

  • Parvalbumins at the US National Library of Medicine Medical Subject Headings MeSH
  • Baig, I; Bertini, I; Del Bianco, C; Gupta, Y K; Lee, Y M; Luchinat, C; Quattrone, A 2004 "Paramagnetism-Based Refinement Strategy for the Solution Structure of Human α-Parvalbumin†" Biochemistry 43 18: 5562–5573 doi:101021/bi035879k PMID 15122922 

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