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Omics

omicsonline.org, omics international
The English-language neologism omics informally refers to a field of study in biology ending in -omics, such as genomics, proteomics or metabolomics The related suffix -ome is used to address the objects of study of such fields, such as the genome, proteome or metabolome respectively Omics aims at the collective characterization and quantification of pools of biological molecules that translate into the structure, function, and dynamics of an organism or organisms

Functional genomics aims at identifying the functions of as many genes as possible of a given organism It combines different -omics techniques such as transcriptomics and proteomics with saturated mutant collections

The suffix -ome as used in molecular biology refers to a totality of some sort; it is an example of a "neo-suffix" formed by abstraction from various Greek terms in -ωμα, a sequence that does not form an identifiable suffix in Greek

Contents

  • 1 Origin
  • 2 Kinds of omics studies
    • 21 Genomics
    • 22 Lipidomics
    • 23 Proteomics
    • 24 Glycomics
    • 25 Foodomics
    • 26 Transcriptomics
    • 27 Metabolism
    • 28 Nutrition, pharmacology, and toxicology
    • 29 Culture
    • 210 Miscellaneous
  • 3 Unrelated words in -omics
  • 4 Current usage
  • 5 See also
  • 6 Notes
  • 7 Further reading
  • 8 External links

Origin

"Omicum":Building of the Estonian Biocentre which houses the Estonian Genome Centre and Institute of Molecular and Cell Biology at the University of Tartu in Tartu, Estonia

The Oxford English Dictionary OED distinguishes three different fields of application for the -ome suffix:

  1. in medicine, forming nouns with the sense "swelling, tumour"
  2. in botany or zoology, forming nouns in the sense "a part of an animal or plant with a specified structure"
  3. in cellular and molecular biology, forming nouns with the sense "all constituents considered collectively"

The -ome suffix originated as a variant of -oma, and became productive in the last quarter of the 19th century It originally appeared in terms like sclerome or rhizome All of these terms derive from Greek words in -ωμα, a sequence that is not a single suffix, but analyzable as -ω-μα, the -ω- belonging to the word stem usually a verb and the -μα being a genuine Greek suffix forming abstract nouns

The OED suggests that its third definition originated as a back-formation from mitome, Early attestations include biome 1916 and genome first coined as German Genom in 1920

The association with chromosome in molecular biology is by false etymology The word chromosome derives from the Greek stems χρωματ- "colour" and σωματ- "body" While σωμα "body" genuinely contains the -μα suffix, the preceding -ω- is not a stem-forming suffix but part of the word's root Because genome refers to the complete genetic makeup of an organism, a neo-suffix -ome suggested itself as referring to "wholeness" or "completion"

Bioinformaticians and molecular biologists figured amongst the first scientists to apply the "-ome" suffix widely Early advocates included bioinformaticians in Cambridge, UK, where there were many early bioinformatics labs such as the MRC centre, Sanger centre, and EBI European Bioinformatics Institute For example, the MRC centre carried out the first genome and proteome projects

Kinds of omics studies

Genomics

  • Genomics:Study of the genomes of organisms
    • Cognitive genomics examines the changes in cognitive processes associated with genetic profiles
    • Comparative genomics:Study of the relationship of genome structure and function across different biological species or strains
    • Functional genomics:Describes gene and protein functions and interactions often uses transcriptomics
    • Metagenomics:Study of metagenomes, ie, genetic material recovered directly from environmental samples
    • Neurogenomics:Study of genetic influences on the development and function of the nervous system
    • Personal genomics:Branch of genomics concerned with the sequencing and analysis of the genome of an individual Once the genotypes are known, the individual's genotype can be compared with the published literature to determine likelihood of trait expression and disease risk Helps in Personalized Medicine
  • Epigenomics:Study of the complete set of epigenetic modifications on the genetic material of a cell, known as the epigenome ChIP-Chip and ChIP-Seq technologies used

Lipidomics

Lipidome is the entire complement of cellular lipids, including the modifications made to a particular set of lipids, produced by an organism or system

  • Lipidomics:Large-scale study of pathways and networks of lipids Mass spectrometry techniques are used

Proteomics

Proteome is the entire complement of proteins, including the modifications made to a particular set of proteins, produced by an organism or system

  • Proteomics:Large-scale study of proteins, particularly their structures and functions Mass spectrometry techniques are used
    • Immunoproteomics:study of large sets of proteins proteomics involved in the immune response
    • Nutriproteomics:Identifying the molecular targets of nutritive and non-nutritive components of the diet Uses proteomics mass spectrometry data for protein expression studies
    • Proteogenomics:An emerging field of biological research at the intersection of proteomics and genomics Proteomics data used for gene annotations
    • Structural genomics:Study of 3-dimensional structure of every protein encoded by a given genome using a combination of experimental and modeling approaches

Glycomics

Glycomics is the comprehensive study of the glycome ie sugars and carbohydrates

Foodomics

Foodomics was defined in 2009 as "a discipline that studies the Food and Nutrition domains through the application and integration of advanced -omics technologies to improve consumer's well-being, health, and knowledge"

Transcriptomics

Transcriptome is the set of all RNA molecules, including mRNA, rRNA, tRNA, and other non-coding RNA, produced in one or a population of cells

  • Transcriptomics:Study of transcriptomes, their structures and functions

Metabolism

  • Metabolomics:Scientific study of chemical processes involving metabolites It is a "systematic study of the unique chemical fingerprints that specific cellular processes leave behind", the study of their small-molecule metabolite profiles
  • Metabonomics:The quantitative measurement of the dynamic multiparametric metabolic response of living systems to pathophysiological stimuli or genetic modification

Nutrition, pharmacology, and toxicology

  • Nutritional genomics:A science studying the relationship between human genome, nutrition and health
    • Nutrigenetics studies the effect of genetic variations on the interaction between diet and health with implications to susceptible subgroups
    • Nutrigenomics:Study of the effects of foods and food constituents on gene expression Studies the effect of nutrients on the genome, proteome, and metabolome
  • Pharmacogenomics investigates the effect of the sum of variations within the human genome on drugs;
  • Pharmacomicrobiomics investigates the effect of variations within the human microbiome on drugs
  • Toxicogenomics:a field of science that deals with the collection, interpretation, and storage of information about gene and protein activity within particular cell or tissue of an organism in response to toxic substances

Culture

Inspired by foundational questions in evolutionary biology, a Harvard team around Jean-Baptiste Michel and Erez Lieberman Aiden created the American neologism culturomics for the application of big data collection and analysis to cultural studies

Miscellaneous

  • Mitointeractome
  • Psychogenomics:Process of applying the powerful tools of genomics and proteomics to achieve a better understanding of the biological substrates of normal behavior and of diseases of the brain that manifest themselves as behavioral abnormalities Applying psychogenomics to the study of drug addiction, the ultimate goal is to develop more effective treatments for these disorders as well as objective diagnostic tools, preventive measures, and eventually cures
  • Stem cell genomics:Helps in stem cell biology Aim is to establish stem cells as a leading model system for understanding human biology and disease states and ultimately to accelerate progress toward clinical translation
  • Connectomics:The study of the connectome, the totality of the neural connections in the brain
  • Microbiomics:the study of the genomes of the communities of microorganisms that live in the digestive tracts of animals
  • Cellomics:Is the quantitative cell analysis and study using bioimaging methods and bioinformatics
  • Tomomics:A combination of tomography and omics methods to understand tissue or cell biochemistry at high spatial resolution, typically using imaging mass spectrometry data
  • Ethomics:Is the high-throughput machine measurement of animal behaviour
  • Videomics or vide-omics:A video analysis paradigm inspired by genomics principles, where a continuous image sequence or video can be interpreted as the capture of a single image evolving through time through mutations revealing ‘a scene’

Unrelated words in -omics

Further information:-nomics

The word “comic” does not use the "omics" suffix; it derives from Greek “κωμο-” merriment + “-ικο-” an adjectival suffix, rather than presenting a truncation of “σωματ-”

Similarly, the word “economy” is assembled from Greek “οικο-” household + “νομο-” law or custom, and “economics” from “οικο-” + “νομο-” + “-ικο-” The suffix -omics is sometimes used to create names for schools of economics, such as Reaganomics

Current usage

Main article:List of omics topics in biology

Many “omes” beyond the original “genome” have become useful and have been widely adopted by research scientists “Proteomics” has become well-established as a term for studying proteins at a large scale "Omes" can provide an easy shorthand to encapsulate a field; for example, an interactomics study is clearly recognisable as relating to large-scale analyses of gene-gene, protein-protein, or protein-ligand interactions Researchers are rapidly taking up omes and omics, as shown by the explosion of the use of these terms in PubMed since the mid '90s

See also

  • Systems biology
  • Panomics

Notes

  1. ^ Holtorf, Hauke; Guitton, Marie-Christine; Reski, Ralf 2002 "Plant functional genomics" Naturwissenschaften 89 6:235–249 doi:101007/s00114-002-0321-3 
  2. ^ "scleroma, n :Oxford English Dictionary" Retrieved 2011-04-25 
  3. ^ "rhizome, n :Oxford English Dictionary" Retrieved 2011-04-25 
  4. ^ "-oma, comb form :Oxford English Dictionary" Retrieved 2011-04-25 
  5. ^ "Home :Oxford English Dictionary" Retrieved 2011-04-25 
  6. ^ "biome, n :Oxford English Dictionary" Retrieved 2011-04-25 
  7. ^ Hans Winkler 1920 Verbreitung und Ursache der Parthenogenesis im Pflanzen - und Tierreiche Verlag Fischer, Jena p 165 Ich schlage vor, für den haploiden Chromosomensatz, der im Verein mit dem zugehörigen Protoplasma die materielle Grundlage der systematischen Einheit darstellt den Ausdruck:das Genom zu verwenden" In English:" I propose the expression Genom for the haploid chromosome set, which, together with the pertinent protoplasm, specifies the material foundations of the species  
  8. ^ a b Coleridge, H; et alii The Oxford English Dictionary
  9. ^ Liddell, HG; Scott, R; et alii A Greek-English LexiconSearch at Perseus Project
  10. ^ Cumpson, Peter; Fletcher, Ian; Sano, Naoko; Barlow, Anders 2016 "Rapid multivariate analysis of 3D ToF-SIMSdata:graphical processor units GPUs and low-discrepancy subsampling for large-scale principal component analysis" Surface and Interface Analysis 48 12:1328 doi:101002/sia6042 Retrieved 20 March 2017 
  11. ^ Reiser, Michael 2009 "The ethomics era" Nature Methods 6 6:413–414 doi:101038/nmeth0609-413 
  12. ^ Kazantzidis, Ioannis; Florez-Revuelta, Francisco; Dequidt, Mickael; Hill, Natasha; Nebel, Jean-Christophe 2018 "Vide-omics:A genomics-inspired paradigm for video analysis" Computer Vision and Image Understanding 166:28–40 doi:101016/jcviu201710003 
  13. ^ Omes Table, Gerstein Lab

Further reading

  • Lederberg, Joshua; McCray, Alexa T April 2, 2001 "Commentary:'Ome Sweet 'Omics — A Genealogical Treasury of Words" The Scientist 15 7:8 Retrieved 1 June 2014 
  • Hotz, Robert Lee 13 August 2012 "Here's an Omical Tale:Scientists Discover Spreading Suffix" The Wall Street Journal 

External links

  • List of omics, including references/origins Maintained by the CHI Cambridge Health Institute
  • Omicsorg The omics terms list portal

omics conferences, omics group, omics international, omics journal, omics meaning, omics publishing group, omics technologies, omics tools, omicsoft, omicsonline.org


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    Omics beatiful post thanks!

    29.10.2014


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