Non-specific interstitial pneumonia


Non-specific interstitial pneumonia NSIP is a form of idiopathic interstitial pneumonia

Contents

  • 1 Symptoms
  • 2 Causes
  • 3 Classification
  • 4 Prognosis
  • 5 References

Symptomsedit

Symptoms include cough, difficulty breathing, and fatigue1

Causesedit

It has been suggested that idiopathic nonspecific interstitial pneumonia has an autoimmune mechanism, and is a possible complication of undifferentiated connective tissue disease2

Classificationedit

Lung biopsies performed on patients with NSIP reveal two different disease patterns - cellular and fibrosing - which are associated with different prognoses The cellular pattern displays chronic inflammation with minimal fibrosis The fibrosing pattern displays interstitial fibrosis with various inflammation levels Both patterns are uniform and lack the prominent fibroblastic foci that are found in other types of idiopathic interstitial pneumonia3

Prognosisedit

The fibrosing pattern of NSIP has a five year survival rate of 86% to 92%, while the cellular pattern of NSIP has a 100% five year survival rate Patients with NSIPwhether cellular or fibrosing, have a better prognosis than those with usual interstitial pneumonia UIP4

Referencesedit

  1. ^ Cottin, V; Donsbeck, AV; Revel, D; Loire, R; Cordier, JF October 1998 "Nonspecific interstitial pneumonia Individualization of a clinicopathologic entity in a series of 12 patients" American journal of respiratory and critical care medicine 158 4: 1286–93 PMID 9769293 doi:101164/ajrccm15849802119 
  2. ^ Kinder, Brent W; Collard, Harold R; Koth, Laura; Daikh, David I; Wolters, Paul J; Elicker, Brett; Jones, Kirk D; King, Talmadge E October 2007 "Idiopathic Nonspecific Interstitial Pneumonia" American Journal of Respiratory and Critical Care Medicine 176 7: 691–697 PMC 1994238  PMID 17556720 doi:101164/rccm200702-220OC 
  3. ^ Travis, William D; Hunninghake, Gary; King, Talmadge E; Lynch, David A; Colby, Thomas V; Galvin, Jeffrey R; Brown, Kevin K; Chung, Man Pyo; Cordier, Jean-François; du Bois, Roland M; Flaherty, Kevin R; Franks, Teri J; Hansell, David M; Hartman, Thomas E; Kazerooni, Ella A; Kim, Dong Soon; Kitaichi, Masanori; Koyama, Takashi; Martinez, Fernando J; Nagai, Sonoko; Midthun, David E; Müller, Nestor L; Nicholson, Andrew G; Raghu, Ganesh; Selman, Moisés; Wells, Athol 15 June 2008 "Idiopathic Nonspecific Interstitial Pneumonia" American Journal of Respiratory and Critical Care Medicine 177 12: 1338–1347 PMID 18388353 doi:101164/rccm200611-1685OC 
  4. ^ Travis, William D; Matsui, Kazuhiro; Moss, Joel; Ferrans, Victor J January 2000 "Idiopathic Nonspecific Interstitial Pneumonia: Prognostic Significance of Cellular and Fibrosing Patterns" The American Journal of Surgical Pathology 24 1: 19 PMID 10632484 doi:101097/00000478-200001000-00003 




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