Thu . 19 Apr 2019

N-Acetylmuramic acid

n-acetylmuramic acid, n-acetylmuramic acid structure
N-Acetylmuramic acid, or MurNAc, is the ether of lactic acid and N-acetylglucosamine with a chemical formula of C11H19NO8 It is part of a biopolymer in the bacterial cell wall, which is built from alternating units of N-acetylglucosamine GlcNAc and N-acetylmuramic acid MurNAc, cross-linked with oligopeptides at the lactic acid residue of MurNAc This layered structure is called peptidoglycan

MurNAc is a monosaccharide derivative of N-acetylglucosamine

Clinical significance

N-Acetylmuramic acid MurNAc is part of the peptidoglycan polymer of bacterial cell walls MurNAc is covalently linked to N-acetylglucosamine and may also be linked through the hydroxyl on carbon number 4 to the carbon of L-alanine A pentapeptide composed of L-alanyl-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine is added to the MurNAc in the process of making the peptidoglycan strands of the cell wall

Synthesis is inhibited by fosfomycin

References

  1. ^ Grif K, Dierich MP, Pfaller K, Miglioli PA, Allerberger F 2001 "In vitro activity of fosfomycin in combination with various antistaphylococcal substances" Journal of Antimicrobial Chemotherapy 48 2: 209–217 doi:101093/jac/482209 PMID 11481290 

See also

  • Amino sugar
  • Glucosamine

n-acetylmuramic acid, n-acetylmuramic acid and lactic acid, n-acetylmuramic acid definition, n-acetylmuramic acid fischer, n-acetylmuramic acid structure


N-Acetylmuramic acid Information about

N-Acetylmuramic acid


  • user icon

    N-Acetylmuramic acid beatiful post thanks!

    29.10.2014


N-Acetylmuramic acid
N-Acetylmuramic acid
N-Acetylmuramic acid viewing the topic.
N-Acetylmuramic acid what, N-Acetylmuramic acid who, N-Acetylmuramic acid explanation

There are excerpts from wikipedia on this article and video

Random Posts

B♭ (musical note)

B♭ (musical note)

B♭ B-flat; also called si bémol is the eleventh step of the Western chromatic scale starting from C ...
Fourth dimension in art

Fourth dimension in art

New possibilities opened up by the concept of four-dimensional space and difficulties involved in tr...
Holt Renfrew

Holt Renfrew

Holt, Renfrew & Co, Limited, commonly known as Holt Renfrew or Holt's,1 is a chain of high-end C...
Later Silla

Later Silla

Later Silla 668–935, Hangul: 후신라; Hanja: 後新羅; RR: Hushila, Korean pronunciation: ...