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N-Acetylmuramic acid

n-acetylmuramic acid, n-acetylmuramic acid structure
N-Acetylmuramic acid, or MurNAc, is the ether of lactic acid and N-acetylglucosamine with a chemical formula of C11H19NO8 It is part of a biopolymer in the bacterial cell wall, which is built from alternating units of N-acetylglucosamine GlcNAc and N-acetylmuramic acid MurNAc, cross-linked with oligopeptides at the lactic acid residue of MurNAc This layered structure is called peptidoglycan

MurNAc is a monosaccharide derivative of N-acetylglucosamine

Clinical significance

N-Acetylmuramic acid MurNAc is part of the peptidoglycan polymer of bacterial cell walls MurNAc is covalently linked to N-acetylglucosamine and may also be linked through the hydroxyl on carbon number 4 to the carbon of L-alanine A pentapeptide composed of L-alanyl-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine is added to the MurNAc in the process of making the peptidoglycan strands of the cell wall

Synthesis is inhibited by fosfomycin

References

  1. ^ Grif K, Dierich MP, Pfaller K, Miglioli PA, Allerberger F 2001 "In vitro activity of fosfomycin in combination with various antistaphylococcal substances" Journal of Antimicrobial Chemotherapy 48 2: 209–217 doi:101093/jac/482209 PMID 11481290 

See also

  • Amino sugar
  • Glucosamine

n-acetylmuramic acid, n-acetylmuramic acid and lactic acid, n-acetylmuramic acid definition, n-acetylmuramic acid fischer, n-acetylmuramic acid structure


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N-Acetylmuramic acid


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    N-Acetylmuramic acid beatiful post thanks!

    29.10.2014


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