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MUC1

muc1, muc16
1SM3, 2ACM

Identifiers Aliases MUC1, ADMCKD, ADMCKD1, CA 15-3, CD227, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM, mucin 1, cell surface associated External IDs HomoloGene: 136477 GeneCards: MUC1 RNA expression pattern



More reference expression data Orthologs Species Human Mouse Entrez
Ensembl
UniProt
RefSeq mRNA

n/a

RefSeq protein

n/a

Location UCSC Chr 1: 15519 – 15519 Mb n/a PubMed search 1 n/a Wikidata
  • ^ "Human PubMed Reference:" 
  • ^ Gendler SJ, Lancaster CA, Taylor-Papadimitriou J, Duhig T, Peat N, Burchell J, Pemberton L, Lalani EN, Wilson D September 1990 "Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin" J Biol Chem 265 25: 15286–93 PMID 1697589 CS1 maint: Multiple names: authors list link
  • ^ a b Hollingsworth MA, Swanson BJ January 2004 "Mucins in cancer: protection and control of the cell surface" Nature Reviews Cancer 4 1: 45–60 PMID 14681689 doi:101038/nrc1251 
  • ^ Moncada DM, Kammanadiminiti SJ, Chadee K July 2003 "Mucin and Toll-like receptors in host defense against intestinal parasites" Trends Parasitol 19 7: 305–311 PMID 12855381 doi:101016/S1471-49220300122-3 
  • ^ Gendler SJ July 2001 "MUC1, the renaissance molecule" J Mammary Gland Biol Neoplasia 6 3: 339–353 PMID 11547902 doi:101023/A:1011379725811 
  • ^ a b Brayman M, Thathiah A, Carson DD January 2004 "MUC1: a multifunctional cell surface component of reproductive tissue epithelia" Reprod Biol Endocrinol 2: 4 PMC 320498  PMID 14711375 doi:101186/1477-7827-2-4 
  • ^ Hattrup CL, Gendler, SJ 2008 "Structure and Function of the Cell Surface Tethered Mucins" Annu Rev Physiol 70: 431–457 PMID 17850209 doi:101146/annurevphysiol70113006100659 CS1 maint: Multiple names: authors list link
  • ^ "Entrez Gene: SEA Domain of MUC1" 
  • ^ Ligtenberg MJ; Kruijshaar :; Buijs F; van Meijer M; Litvinov SV; Hilkens J March 1992 "Cell-associated episialin is a complex containing two proteins derived from a common precursor" J Biol Chem 267 9: 6171–6177 PMID 1556125 
  • ^ Julian J, Carson DD May 2002 "Formation of MUC1 metabolic complex is conserved in tumor-derived and normal epithelial cells" Biochem Biophys Res Commun 293 4: 1183–1190 PMID 12054500 doi:101016/S0006-291X0200352-2 
  • ^ a b Singh PK, Hollingsworth MA August 2006 "Cell surface-associated mucins in signal transduction" Trends Cell Biol 16 9: 467–476 PMID 16904320 doi:101016/jtcb200607006 
  • ^ Lindén SK, Sheng YH, Every AL, Miles KM, Skoog EC, Florin TH, Sutton P, McGuckin MA October 2009 "MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy" PLoS Pathog 5 10: e1000617 PMC 2752161  PMID 19816567 doi:101371/journalppat1000617 
  • ^ Tolcher AW, Ochoa L, Hammond LA, Patnaik A, Edwards T, Takimoto C, Smith L, de Bono J, Schwartz G, Mays T, Jonak ZL, Johnson R, DeWitte M, Martino H, Audette C, Maes K, Chari RV, Lambert JM, Rowinsky EK January 2003 "Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: a phase I, pharmacokinetic, and biologic correlative study" J Clin Oncol 21 2: 211–22 PMID 12525512 doi:101200/JCO200305137 
  • ^ Cooper K; Leong AS-Y; Leong JW-M 2003 Manual of diagnostic antibodies for immunohistology London: Greenwich Medical Media pp 205–206 ISBN 1-84110-100-1 
  • ^ Li Y, Kufe D February 2001 "The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120ctn" Biochem Biophys Res Commun 281 2: 440–3 PMID 11181067 doi:101006/bbrc20014383 
  • ^ a b Li Y, Yu WH, Ren J, Chen W, Huang L, Kharbanda S, Loda M, Kufe D August 2003 "Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein" Mol Cancer Res 1 10: 765–75 PMID 12939402 
  • ^ a b Schroeder JA, Thompson MC, Gardner MM, Gendler SJ April 2001 "Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland" J Biol Chem 276 16: 13057–64 PMID 11278868 doi:101074/jbcM011248200 
  • ^ a b Pandey P, Kharbanda S, Kufe D September 1995 "Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein" Cancer Res 55 18: 4000–4003 PMID 7664271 
  • ^ Wei X, Xu H, Kufe D February 2005 "Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response" Cancel Cell 7 2: 167–178 PMID 15710329 doi:101016/jccr200501008 
  • ^ Raina D, Kharbanda S, Kufe D May 2004 "The MUC1 oncoprotein activates the anti-apoptotic phosphoinositide 3-kinase/Akt and Bcl-xL pathways in rat 3Y1 fibroblasts" J Biol Chem 279 20: 20607–20612 PMID 14999001 doi:101074/jbcM310538200 
  • ^ Ren J, Bharti A, Raina D, Chen W, Ahmad R, Kufe D January 2006 "MUC1 oncoprotein is targeted to mitochondria by heregulin-induced activation of c-Src and the molecular chaperone HSP90" Oncogene 25 1: 20–31 PMID 16158055 doi:101038/sjonc1209012 
  • ^ Yamamoto M, Bharti A, Li Y, Kufe D May 1997 "Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion" J Biol Chem 272 19: 12492–4 PMID 9139698 doi:101074/jbc2721912492 
  • ^ Li Y, Chen W, Ren J, Yu WH, Li Q, Yoshida K, Kufe D 2003 "DF3/MUC1 signaling in multiple myeloma cells is regulated by interleukin-7" Cancer Biol Ther 2 2: 187–93 PMID 12750561 doi:104161/cbt22282 
  • ^ Li Y, Kuwahara H, Ren J, Wen G, Kufe D March 2001 "The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin" J Biol Chem 276 9: 6061–4 PMID 11152665 doi:101074/jbcC000754200 
  • ^ Li Y, Ren J, Yu W, Li Q, Kuwahara H, Yin L, Carraway KL, Kufe D September 2001 "The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin" J Biol Chem 276 38: 35239–42 PMID 11483589 doi:101074/jbcC100359200 
  • ^ Ren J, Li Y, Kufe D May 2002 "Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling" J Biol Chem 277 20: 17616–22 PMID 11877440 doi:101074/jbcM200436200 
  • ^ Li Y, Bharti A, Chen D, Gong J, Kufe D December 1998 "Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin" Mol Cell Biol 18 12: 7216–24 PMC 109303  PMID 9819408 doi:101128/mcb18127216 
  • ^ Huang L, Chen D, Liu D, Yin L, Kharbanda S, Kufe D November 2005 "MUC1 oncoprotein blocks glycogen synthase kinase 3beta-mediated phosphorylation and degradation of beta-catenin" Cancer Res 65 22: 10413–10422 PMID 16288032 doi:101158/0008-5472CAN-05-2474 
  • ^ Schroeder JA, Adriance MC, Thompson MC, Camenisch TD, Gendler SJ March 2003 "MUC1 alters beta-catenin-dependent tumor formation and promotes cellular invasion" Oncogene 22 9: 1324–32 PMID 12618757 doi:101038/sjonc1206291 
  • ^ Roy LD, Sahraei M, Subramani DB, Besmer D, Nath S, Tinder TL, Bajaj E, Shanmugam K, Lee YY, Hwang SI, Gendler SJ, Mukherjee P March 2011 "MUC1 enhances invasiveness of pancreatic cancer cells by inducing epithelial to mesenchymal transition" Oncogene 30 12: 1449–1459 PMC 3063863  PMID 21102519 doi:101038/onc2010526 
  • ^ Gaidzik N, Westerlind U, Kunz H May 2013 "The development of synthetic antitumour vaccines from mucin glycopeptide antigens" Chem Soc Rev 42 10: 4421–42 PMID 23440054 doi:101039/c3cs35470a 
  • ^ Phase 1 dose escalation of ONT-10, a therapeutic MUC1 vaccine, in patients with advanced cancer 2013
  • Further readingedit

    • Peterson JA, Scallan CD, Ceriani RL, Hamosh M 2002 "Structural and functional aspects of three major glycoproteins of the human milk fat globule membrane" Adv Exp Med Biol 501: 179–87 PMID 11787681 doi:101007/978-1-4615-1371-1_23 
    • Hu XF, Yang E, Li J, Xing PX 2006 "MUC1 cytoplasmic tail: a potential therapeutic target for ovarian carcinoma" Expert Rev Anticancer Ther 6 8: 1261–71 PMID 16925492 doi:101586/14737140681261 
    • Leroy X, Buisine MP, Leteurtre E, et al 2007 "MUC1 EMA: A key molecule of carcinogenesis" Annales de pathologie 26 4: 257–66 PMID 17128152 doi:101016/S0242-64980670718-0 
    • Li Y, Cozzi PJ 2007 "MUC1 is a promising therapeutic target for prostate cancer therapy" Current cancer drug targets 7 3: 259–71 PMID 17504123 doi:102174/156800907780618338 
    • Mahanta S, Fessler SP, Park J, Bamdad C 2008 Cordes, Nils, ed "A Minimal Fragment of MUC1 Mediates Growth of Cancer Cells" PLoS ONE 3 4: e2054 PMC 2329594  PMID 18446242 doi:101371/journalpone0002054 CS1 maint: Multiple names: authors list link
    • Hikita ST, Kosik KS, Clegg DO, Bamdad C 2008 Cordes, Nils, ed "MUC1 mediates the growth of human pluripotent stem cells" PLoS ONE 3 10: e3312 PMC 2553196  PMID 18833326 doi:101371/journalpone0003312 CS1 maint: Multiple names: authors list link
    • Fessler SP, Wotkowicz MT, Mahanta S, Bamdad C 2009 "MUC1 is a determinant of trastuzumab Herceptin resistance in breast cancer cells" Breast Cancer Res Treat 118 1: 113–24 PMID 19415485 doi:101007/s10549-009-0412-3 
    • Zhan XX, Zhao B, Diao C, Cao Y, Cheng RC 2015 "Expression of MUC1 and CD176 Thomsen-Friedenreich antigen in papillary thyroid carcinomas" Endocr Pathol 26 1: 21–6 PMID 25614211 doi:101007/s12022-015-9356-9 

    External linksedit

    • MUC1 protein, human at the US National Library of Medicine Medical Subject Headings MeSH

    This article incorporates text from the United States National Library of Medicine, which is in the public domain

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    MUC1


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      29.10.2014


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