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Methylpiperidinopyrazole


Methylpiperidinopyrazole MPP is a synthetic, nonsteroidal, and highly selective antagonist of ERα that is used in scientific research to study the function of this receptor It has 200-fold selectivity for ERα over ERβ and 1000-fold selectivity for blocking ERα-mediated gene transcription relative to that of ERβ

See also

  • Glyceollin
  • Propylpyrazoletriol PPT
  • Diarylpropionitrile DPN
  • Prinaberel ERB-041
  • Liquiritigenin
  • Menerba
  • PHTPP
  • R,R-Tetrahydrochrysene R,R-THC

References

  1. ^ Tony M Plant; Anthony J Zeleznik 15 November 2014 Knobil and Neill's Physiology of Reproduction: Two-Volume Set Academic Press pp 2311– ISBN 978-0-12-397769-4 
  2. ^ Cytoplasmic and Nuclear Receptors—Advances in Research and Application: 2012 Edition ScholarlyEditions 26 December 2012 pp 220– ISBN 978-1-4649-9741-9 
  3. ^ Synthesis of Non-steroidal Estrogen Receptor Proteolysis Targeting Chimeric Molecules PROTACS ProQuest 2008 pp 11– ISBN 978-0-549-90990-3 
  4. ^ Eckhard Ottow; Hilmar Weinmann 8 September 2008 Nuclear Receptors as Drug Targets John Wiley & Sons pp 50– ISBN 978-3-527-62330-3 




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