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Mesothelin

mesothelin protein, mesothelin level
4F3F

Identifiers Aliases MSLN, MPF, SMRP, mesothelin External IDs OMIM: 601051 MGI: 1888992 HomoloGene: 4249 GeneCards: MSLN Orthologs Species Human Mouse Entrez
Ensembl
UniProt
RefSeq mRNA

NM_001177355
NM_005823
NM_013404

NM_018857

RefSeq protein

NP_001170826
NP_005814
NP_037536

NP_061345

Location UCSC Chr 16: 076 – 077 Mb Chr 17: 2575 – 2575 Mb PubMed search 1 2 Wikidata
  • ^ "Human PubMed Reference:" 
  • ^ "Mouse PubMed Reference:" 
  • ^ Kojima T, Oh-eda M, Hattori K, Taniguchi Y, Tamura M, Ochi N, Yamaguchi N September 1995 "Molecular cloning and expression of megakaryocyte potentiating factor cDNA" J Biol Chem 270 37: 21984–90 PMID 7665620 doi:101074/jbc2703721984 
  • ^ Chang K, Pastan I January 1996 "Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers" Proc Natl Acad Sci USA 93 1: 136–40 PMC 40193  PMID 8552591 doi:101073/pnas931136 
  • ^ Chang K, Pai LH, Batra JK, Pastan I, Willingham MC January 1992 "Characterization of the Antigen CAK1 Recognized by Monoclonal Antibody K1 Present on Ovarian Cancers and Normal Mesothelium" Cancer Res 52 1: 181–6 PMID 1727378 
  • ^ a b Hassan R, Bera T, Pastan I June 2004 "Mesothelin: a new target for immunotherapy" Clin Cancer Res 10 12 Pt 1: 3937–42 PMID 15217923 doi:101158/1078-0432CCR-03-0801 
  • ^ Bera TK, Pastan I 2000 "Mesothelin is not required for normal mouse development or reproduction" Molecular and Cellular Biology 20 8: 2902–6 PMC 85523  PMID 10733593 doi:101128/MCB2082902-29062000 
  • ^ a b Hassan R, Ho M January 2008 "Mesothelin targeted cancer immunotherapy" Eur J Cancer 44 1: 46–53 PMC 2265108  PMID 17945478 doi:101016/jejca200708028 
  • ^ Morello A, Sadelain M, Adusumilli PS 2016 "Mesothelin-Targeted CARs: Driving T Cells to Solid Tumors" Cancer Discovery 6 2: 133–46 PMC 4744527  PMID 26503962 doi:101158/2159-8290CD-15-0583 
  • ^ Scholler N, Fu N, Yang Y, Ye Z, Goodman GE, Hellström KE, Hellström I September 1999 "Soluble members of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma" Proc Natl Acad Sci USA 96 20: 11531–6 Bibcode:1999PNAS9611531S PMC 18068  PMID 10500211 doi:101073/pnas962011531 
  • ^ Maeda M, Hino O 2006 "Blood tests for asbestos-related mesothelioma" Oncology 71 1–2: 26–31 PMID 17344668 doi:101159/000100446 
  • ^ a b Hassan R, Remaley AT, Sampson ML, Zhang J, Cox DD, Pingpank J, Alexander R, Willingham M, Pastan I, Onda M January 2006 "Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer" Clin Cancer Res 12 2: 447–53 PMID 16428485 doi:101158/1078-0432CCR-05-1477 
  • ^ a b Iwahori K, Osaki T, Serada S, Fujimoto M, Suzuki H, Kishi Y, Yokoyama A, Hamada H, Fujii Y, Yamaguchi K, Hirashima T, Matsui K, Tachibana I, Nakamura Y, Kawase I, Naka T October 2008 "Megakaryocyte potentiating factor as a tumor marker of malignant pleural mesothelioma: evaluation in comparison with mesothelin" Lung Cancer 62 1: 45–54 PMID 18394747 doi:101016/jlungcan200802012 
  • ^ Johnston FM, Tan MC, Tan BR, Porembka MR, Brunt EM, Linehan DC, Simon PO, Plambeck-Suess S, Eberlein TJ, Hellstrom KE, Hellstrom I, Hawkins WG, Goedegebuure P November 2009 "Circulating mesothelin protein and cellular antimesothelin immunity in patients with pancreatic cancer" Clin Cancer Res 15 21: 6511–8 PMC 2782601  PMID 19843662 doi:101158/1078-0432CCR-09-0565 
  • ^ a b Sharon E, Zhang J, Hollevoet K, Steinberg SM, Pastan I, Onda M, Gaedcke J, Ghadimi BM, Ried T, Hassan R April 2012 "Serum mesothelin and megakaryocyte potentiating factor in pancreatic and biliary cancers" Clin Chem Lab Med 50 4: 721–5 PMID 22149739 doi:101515/CCLM2011816 
  • Further readingedit

    • Alvarez H, Rojas PL, Yong KT, Ding H, Xu G, Prasad PN, Wang J, Canto M, Eshleman JR, Montgomery EA, Maitra A December 2008 "Mesothelin is a specific biomarker of invasive cancer in the Barrett-associated adenocarcinoma progression model: translational implications for diagnosis and therapy" Nanomedicine 4 4: 295–301 PMC 2606904  PMID 18691948 doi:101016/jnano200806006 
    • Cristaudo A, Foddis R, Bonotti A, Simonini S, Vivaldi A, Guglielmi G, Bruno R, Landi D, Gemignani F, Landi S April 2010 "Polymorphisms in the putative micro-RNA-binding sites of mesothelin gene are associated with serum levels of mesothelin-related protein" Occup Environ Med 67 4: 233–6 PMID 19858537 doi:101136/oem2009049205 
    • Pu RT, Pang Y, Michael CW January 2008 "Utility of WT-1, p63, MOC31, mesothelin, and cytokeratin K903 and CK5/6 immunostains in differentiating adenocarcinoma, squamous cell carcinoma, and malignant mesothelioma in effusions" Diagn Cytopathol 36 1: 20–5 PMID 18064689 doi:101002/dc20747 
    • Inami K, Kajino K, Abe M, Hagiwara Y, Maeda M, Suyama M, Watanabe S, Hino O December 2008 "Secretion of N-ERC/mesothelin and expression of C-ERC/mesothelin in human pancreatic ductal carcinoma" Oncol Rep 20 6: 1375–80 PMID 19020717 doi:103892/or_00000155 
    • Roe OD, Creaney J, Lundgren S, Larsson E, Sandeck H, Boffetta P, Nilsen TI, Robinson B, Kjaerheim K August 2008 "Mesothelin-related predictive and prognostic factors in malignant mesothelioma: a nested case-control study" Lung Cancer 61 2: 235–43 PMID 18281122 doi:101016/jlungcan200712025 
    • Johnson MD, Vito F, O'Connell MJ June 2008 "Mesothelin expression in the leptomeninges and meningiomas" J Histochem Cytochem 56 6: 579–85 PMC 2386771  PMID 18347077 doi:101369/jhc2008950477 
    • Schneider J, Hoffmann H, Dienemann H, Herth FJ, Meister M, Muley T November 2008 "Diagnostic and prognostic value of soluble mesothelin-related proteins in patients with malignant pleural mesothelioma in comparison with benign asbestosis and lung cancer" J Thorac Oncol 3 11: 1317–24 PMID 18978568 doi:101097/JTO0b013e318187491c 
    • Pass HI, Wali A, Tang N, Ivanova A, Ivanov S, Harbut M, Carbone M, Allard J January 2008 "Soluble mesothelin-related peptide level elevation in mesothelioma serum and pleural effusions" Ann Thorac Surg 85 1: 265–72; discussion 272 PMID 18154821 doi:101016/jathoracsur200707042 
    • Sapede C, Gauvrit A, Barbieux I, Padieu M, Cellerin L, Sagan C, Scherpereel A, Dabouis G, Grégoire M March 2008 "Aberrant splicing and protease involvement in mesothelin release from epithelioid mesothelioma cells" Cancer Sci 99 3: 590–4 PMID 18167128 doi:101111/j1349-7006200700715x 
    • Li M, Bharadwaj U, Zhang R, Zhang S, Mu H, Fisher WE, Brunicardi FC, Chen C, Yao Q February 2008 "Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer" Mol Cancer Ther 7 2: 286–96 PMC 2929838  PMID 18281514 doi:101158/1535-7163MCT-07-0483 
    • Uehara N, Matsuoka Y, Tsubura A February 2008 "Mesothelin promotes anchorage-independent growth and prevents anoikis via extracellular signal-regulated kinase signaling pathway in human breast cancer cells" Mol Cancer Res 6 2: 186–93 PMID 18245228 doi:101158/1541-7786MCR-07-0254 
    • Iwahori K, Osaki T, Serada S, Fujimoto M, Suzuki H, Kishi Y, Yokoyama A, Hamada H, Fujii Y, Yamaguchi K, Hirashima T, Matsui K, Tachibana I, Nakamura Y, Kawase I, Naka T October 2008 "Megakaryocyte potentiating factor as a tumor marker of malignant pleural mesothelioma: evaluation in comparison with mesothelin" Lung Cancer 62 1: 45–54 PMID 18394747 doi:101016/jlungcan200802012 
    • Creaney J, Yeoman D, Demelker Y, Segal A, Musk AW, Skates SJ, Robinson BW August 2008 "Comparison of osteopontin, megakaryocyte potentiating factor, and mesothelin proteins as markers in the serum of patients with malignant mesothelioma" J Thorac Oncol 3 8: 851–7 PMID 18670302 doi:101097/JTO0b013e318180477b 
    • Shiomi K, Hagiwara Y, Sonoue K, Segawa T, Miyashita K, Maeda M, Izumi H, Masuda K, Hirabayashi M, Moroboshi T, Yoshiyama T, Ishida A, Natori Y, Inoue A, Kobayashi M, Sakao Y, Miyamoto H, Takahashi K, Hino O March 2008 "Sensitive and specific new enzyme-linked immunosorbent assay for N-ERC/mesothelin increases its potential as a useful serum tumor marker for mesothelioma" Clin Cancer Res 14 5: 1431–7 PMID 18316566 doi:101158/1078-0432CCR-07-1613 
    • Kaneko O, Gong L, Zhang J, Hansen JK, Hassan R, Lee B, Ho M February 2009 "A binding domain on mesothelin for CA125/MUC16" J Biol Chem 284 6: 3739–49 PMC 2635045  PMID 19075018 doi:101074/jbcM806776200 
    • Chang MC, Chen CA, Hsieh CY, Lee CN, Su YN, Hu YH, Cheng WF December 2009 "Mesothelin inhibits paclitaxel-induced apoptosis through the PI3K pathway" Biochem J 424 3: 449–58 PMID 19747165 doi:101042/BJ20082196 
    • Cheng WF, Huang CY, Chang MC, Hu YH, Chiang YC, Chen YL, Hsieh CY, Chen CA April 2009 "High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma" Br J Cancer 100 7: 1144–53 PMC 2669998  PMID 19293794 doi:101038/sjbjc6604964 
    • Hellstrom I, Hellstrom KE 2008 "SMRP and HE4 as biomarkers for ovarian carcinoma when used alone and in combination with CA125 and/or each other" Adv Exp Med Biol Advances in Experimental Medicine and Biology 622: 15–21 ISBN 978-0-387-68966-1 PMID 18546615 doi:101007/978-0-387-68969-2_2 
    • Bharadwaj U, Li M, Chen C, Yao Q 2008 "Mesothelin-Induced Pancreatic Cancer Cell Proliferation Involves Alteration of Cyclin E via Activation of Stat3" Mol Cancer Res 6 11: 1755–65 PMC 2929833  PMID 19010822 doi:101158/1541-7786MCR-08-0095 

    External linksedit

    • MSLN human gene location in the UCSC Genome Browser
    • MSLN human gene details in the UCSC Genome Browser

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    Mesothelin Information about

    Mesothelin


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      Mesothelin beatiful post thanks!

      29.10.2014


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