Thu . 19 Apr 2019

Membrane glucocorticoid receptor

membrane glucocorticoid receptor antagonist, membrane glucocorticoid receptor signaling
Membrane glucocorticoid receptors mGRs are a group of receptors which bind and are activated by glucocorticoids such as cortisol and corticosterone, as well as certain exogenous glucocorticoids such as dexamethasone Unlike the classical nuclear glucocorticoid receptor GR, which mediates its effects via genomic mechanisms, mGRs are cell surface receptors which rapidly alter cell signaling via modulation of intracellular signaling cascades The identities of the mGRs have yet to be fully elucidated, but are thought to include membrane-associated classical GRs as well as yet-to-be-characterized G protein-coupled receptors GPCRs Rapid effects of dexamethasone were found not be reversed by the GR antagonist mifepristone, indicating additional receptors besides just the classical GR

mGRs have been implicated in the rapid effects of glucocorticoids in the early central stress response via modulating neuronal activity in the hypothalamus, hippocampus, amygdala, and prefrontal cortex, among other areas In accordance, glucocorticoids are known to affect cognition, stress-adaptive behavior, and neuroendocrine output eg, suppression of oxytocin and vasopressin secretion within minutes mGRs appear to be partially involved in the anti-inflammatory and immunosuppressant effects of glucocorticoids mGRs are present in and appear to regulate many major bodily systems and organs, including the cardiovascular, immune, endocrine, and nervous systems, smooth and skeletal muscle, the liver, and fat tissue mGRs appear to cooperate with, complement, and synergize with classical nuclear GRs in various ways

See also

  • Membrane steroid receptor

References

  1. ^ a b Tasker JG, Di S, Malcher-Lopes R 2006 "Minireview: rapid glucocorticoid signaling via membrane-associated receptors" Endocrinology 147 12: 5549–56 doi:101210/en2006-0981 PMC 3280589  PMID 16946006 
  2. ^ a b Stahn C, Buttgereit F 2008 "Genomic and nongenomic effects of glucocorticoids" Nat Clin Pract Rheumatol 4 10: 525–33 doi:101038/ncprheum0898 PMID 18762788 
  3. ^ a b c Grzanka A, Jarzab J 2009 "" Pneumonol Alergol Pol in Polish 77 4: 387–93 PMID 19722144 
  4. ^ a b c Di S, Tasker JG 2008 "Rapid synapse-specific regulation of hypothalamic magnocellular neurons by glucocorticoids" Prog Brain Res 170: 379–88 doi:101016/S0079-61230800431-7 PMID 18655897 
  5. ^ a b Löwenberg M, Stahn C, Hommes DW, Buttgereit F 2008 "Novel insights into mechanisms of glucocorticoid action and the development of new glucocorticoid receptor ligands" Steroids 73 9-10: 1025–9 doi:101016/jsteroids200712002 PMID 18221974 
  6. ^ Wang C, Liu Y, Cao JM 2014 "G protein-coupled receptors: extranuclear mediators for the non-genomic actions of steroids" Int J Mol Sci 15 9: 15412–25 doi:103390/ijms150915412 PMC 4200746  PMID 25257522 
  7. ^ a b c Groeneweg FL, Karst H, de Kloet ER, Joëls M 2011 "Rapid non-genomic effects of corticosteroids and their role in the central stress response" J Endocrinol 209 2: 153–67 doi:101530/JOE-10-0472 PMID 21357682 
  8. ^ Song IH, Buttgereit F 2006 "Non-genomic glucocorticoid effects to provide the basis for new drug developments" Mol Cell Endocrinol 246 1-2: 142–6 doi:101016/jmce200511012 PMID 16388891 
  9. ^ a b Kawata M, Hirahara-Wada Y, Matsuda K 2008 "" Nippon Rinsho in Japanese 66 1: 55–62 PMID 18193544 
  10. ^ Stellato C 2004 "Post-transcriptional and nongenomic effects of glucocorticoids" Proc Am Thorac Soc 1 3: 255–63 doi:101513/pats200402-015MS PMID 16113443 
  11. ^ Urbach V, Verriere V, Grumbach Y, Bousquet J, Harvey BJ 2006 "Rapid anti-secretory effects of glucocorticoids in human airway epithelium" Steroids 71 4: 323–8 doi:101016/jsteroids200509014 PMID 16298406 
  12. ^ Sarabdjitsingh RA, Joëls M, de Kloet ER 2012 "Glucocorticoid pulsatility and rapid corticosteroid actions in the central stress response" Physiol Behav 106 1: 73–80 doi:101016/jphysbeh201109017 PMID 21971364 
  13. ^ Groeneweg FL, Karst H, de Kloet ER, Joëls M 2012 "Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling" Mol Cell Endocrinol 350 2: 299–309 doi:101016/jmce201106020 PMID 21736918 
  14. ^ Löwenberg M, Verhaar AP, van den Brink GR, Hommes DW 2007 "Glucocorticoid signaling: a nongenomic mechanism for T-cell immunosuppression" Trends Mol Med 13 4: 158–63 doi:101016/jmolmed200702001 PMID 17293163 
  15. ^ Samarasinghe RA, Witchell SF, DeFranco DB 2012 "Cooperativity and complementarity: synergies in non-classical and classical glucocorticoid signaling" Cell Cycle 11 15: 2819–27 doi:104161/cc21018 PMC 3419059  PMID 22801547 


membrane glucocorticoid receptor antagonist, membrane glucocorticoid receptor corticosteroids, membrane glucocorticoid receptor signaling, membrane glucocorticoid receptor structure


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Membrane glucocorticoid receptor


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    29.10.2014


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