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Membrane glucocorticoid receptor

membrane glucocorticoid receptor antagonist, membrane glucocorticoid receptor signaling
Membrane glucocorticoid receptors mGRs are a group of receptors which bind and are activated by glucocorticoids such as cortisol and corticosterone, as well as certain exogenous glucocorticoids such as dexamethasone Unlike the classical nuclear glucocorticoid receptor GR, which mediates its effects via genomic mechanisms, mGRs are cell surface receptors which rapidly alter cell signaling via modulation of intracellular signaling cascades The identities of the mGRs have yet to be fully elucidated, but are thought to include membrane-associated classical GRs as well as yet-to-be-characterized G protein-coupled receptors GPCRs Rapid effects of dexamethasone were found not be reversed by the GR antagonist mifepristone, indicating additional receptors besides just the classical GR

mGRs have been implicated in the rapid effects of glucocorticoids in the early central stress response via modulating neuronal activity in the hypothalamus, hippocampus, amygdala, and prefrontal cortex, among other areas In accordance, glucocorticoids are known to affect cognition, stress-adaptive behavior, and neuroendocrine output eg, suppression of oxytocin and vasopressin secretion within minutes mGRs appear to be partially involved in the anti-inflammatory and immunosuppressant effects of glucocorticoids mGRs are present in and appear to regulate many major bodily systems and organs, including the cardiovascular, immune, endocrine, and nervous systems, smooth and skeletal muscle, the liver, and fat tissue mGRs appear to cooperate with, complement, and synergize with classical nuclear GRs in various ways

See also

  • Membrane steroid receptor


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  6. ^ Wang C, Liu Y, Cao JM 2014 "G protein-coupled receptors: extranuclear mediators for the non-genomic actions of steroids" Int J Mol Sci 15 9: 15412–25 doi:103390/ijms150915412 PMC 4200746  PMID 25257522 
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  13. ^ Groeneweg FL, Karst H, de Kloet ER, Joëls M 2012 "Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling" Mol Cell Endocrinol 350 2: 299–309 doi:101016/jmce201106020 PMID 21736918 
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  15. ^ Samarasinghe RA, Witchell SF, DeFranco DB 2012 "Cooperativity and complementarity: synergies in non-classical and classical glucocorticoid signaling" Cell Cycle 11 15: 2819–27 doi:104161/cc21018 PMC 3419059  PMID 22801547 

membrane glucocorticoid receptor antagonist, membrane glucocorticoid receptor corticosteroids, membrane glucocorticoid receptor signaling, membrane glucocorticoid receptor structure

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Membrane glucocorticoid receptor

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