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Maxwell Wintrobe

maxwell wintrobe tube, maxwell wintrobe method
Maxwell Myer Wintrobe October 27, 1901 – December 9, 1986 was an Austrian-born physician who was a 20th-century authority in the medical field of hematology His textbook on hematology was the first dedicated work in the field, and he contributed to the diagnostic approach of anemia and copper metabolism, amongst many other achievements


  • 1 Biography
  • 2 Works
  • 3 References
  • 4 External links


Wintrobe was born in Austria Fred 2007, contrary to previous historical records His family name of reflects the Jewish origin of his parents, Herman and Ethel, who emigrated from Austria with their son Max in 1906 Canadian census records show that the family arrived in Halifax, Nova Scotia in 1906 where Ethel's four brothers were living at the time The family moved to Manitoba in 1912 Wintrobe attended the University of Manitoba from the early age of fifteen, where he graduated in 1921 and obtained his MD in 1926 He married Becky Zamphir, and moved to the United States, where he obtained a PhD at Tulane University in New Orleans, Louisiana in 1929; his thesis was titled "The Erythrocyte in Man"

Initially working in Johns Hopkins Hospital, where he served on the faculty, he was appointed as professor of internal medicine at the College of Medicine of the University of Utah in 1943; he also served as the first Chairman of the Department of Medicine and physician-in-chief for the Salt Lake County General Hospital

In Salt Lake City he led research in hereditary and metabolic disorders 1945–1973 and cardiovascular research 1969–1973 He retired officially in 1965, but remained in function until 1973 Valentine 1990 In that year he was elected to the National Academy of Sciences


In New Orleans, Wintrobe pioneered new ways of measuring the hematocrit, including what are now known as Wintrobe indices: mean cell volume, mean cell hemoglobin, and mean cell hemoglobin concentration, all quantitative measures of the red blood cell population Wintrobe 1932 Much of this work continued in Hopkins and Utah, where he also worked on pernicious anemia, copper metabolism and Wilson's disease, sickle-cell disease and other anemias

Wintrobe was the principal editor of Clinical Hematology, which first appeared in 1942 and is in its eleventh edition Greer et al as of 2003, still bearing his name He was part of the team that pioneered the use of chemotherapy in cancer Goodman et al 1946 He was one of the editors of the first edition 1950 of Harrison's Principles of Internal Medicine

In 1980 he published Blood, pure and eloquent, and in 1985 appeared Hematology, the Blossoming of a Science Both works are historical overviews of his field


  • Fred, H L 2007 "Maxwell Myer Wintrobe: New history and a new appreciation" Texas Heart Institute journal / from the Texas Heart Institute of St Luke's Episcopal Hospital, Texas Children's Hospital 34 3: 328–335 PMC 1995040  PMID 17948084 
  • Goodman, L S; Wintrobe, M M; Dameshek, W; Goodman, M J; Gilman, A; McLennan, M T 1984 "Landmark article Sept 21, 1946: Nitrogen mustard therapy Use of methyl-bisbeta-chloroethylamine hydrochloride and trisbeta-chloroethylamine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders By Louis S Goodman, Maxwell M Wintrobe, William Dameshek, Morton J Goodman, Alfred Gilman and Margaret T McLennan" JAMA: the Journal of the American Medical Association 251 17: 2255–2261 doi:101001/jama251172255 PMID 6368885 
  • Greer JP, Foerster J, Lukens JN Wintrobe's Clinical Hematology, 11th edition Lippincott Williams & Wilkins, 2003 ISBN 0-7817-3650-1
  • Valentine WN Maxwell Myer Wintrobe In "Biographical Memoirs" National Academy of Sciences 1990;59:446-472 ISBN 0-309-04198-8 Fulltext
  • Wintrobe, M M 1990 "The size and hemoglobin content of the erythrocyte Methods of determination and clinical application 1932" The Journal of laboratory and clinical medicine 115 3: 374–387 PMID 2179436 
  • Wintrobe MM Blood, pure and eloquent; a story of discovery, of people and ideas New York: McGraw-Hill, 1980 ISBN 0-07-071135-6
  • Wintrobe MM Hematology, the Blossoming of a Science: A Story of Inspiration and Effort Lippincott Williams & Wilkins, 1985 ISBN 0-8121-0961-9

External links

  • Collection of papers at the University of Utah

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Maxwell Wintrobe

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