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Major basic protein

major basic protein, major basic protein function
1H8U, 2BRS, 4QXX

IdentifiersAliasesPRG2, BMPG, MBP, MBP1, proteoglycan 2, bone marrow natural killer cell activator, eosinophil granule major basic protein, proMBP, proteoglycan 2, pro eosinophil major basic proteinExternal IDsOMIM: 605601 MGI: 103294 HomoloGene: 2044 GeneCards: PRG2
Gene location Human
ChrChromosome 11 human[1]
Band11q121Start57,386,794 bp[1]
End57,390,657 bp[1]
RNA expression pattern
More reference expression data
OrthologsSpeciesHumanMouseEntrez
Ensembl
UniProt
RefSeq mRNA

NM_002728
NM_001243245
NM_001302926
NM_001302927

NM_008920

RefSeq protein

NP_001230174
NP_001289855
NP_001289856
NP_002719

NP_032946

Location UCSCChr 11: 5739 – 5739 MbChr 2: 8498 – 8498 MbPubMed search[3][4]Wikidata
1 Function
  • 2 Structure
  • 3 Interactions
  • 4 See also
  • 5 References
  • 6 External links
  • 7 Further reading
  • Function

    The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A PAPPA, angiotensinogen AGT, and C3dg This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases[5]

    PRG2 is a 117-residue protein that predominates in eosinophil granules It is a potent enzyme against helminths and is toxic towards bacteria and mammalian cells in vitro The eosinophil major basic protein also causes the release of histamine from mast cells and basophils, and activates neutrophils and alveolar macrophages

    Structure

    Structurally the major basic protein MBP is similar to lectins sugar-binding proteins, and has a fold similar to that seen in C-type lectins However, unlike other C-type lectins those that bind various carbohydrates in the presence of calcium, MBP does not bind either calcium or any of the other carbohydrates that this family recognize

    Instead, MBP recognises heparan sulfate proteoglycans Two crystallographic structures of MBP have been determined[6][7]

    Interactions

    Major basic protein has been shown to interact with Pregnancy-associated plasma protein A[8][9][10]

    See also

    arylsulfatase

    References

    1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186652 - Ensembl, May 2017
    2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027073 - Ensembl, May 2017
    3. ^ "Human PubMed Reference:" 
    4. ^ "Mouse PubMed Reference:" 
    5. ^ a b "Entrez Gene: PRG2 proteoglycan 2, bone marrow natural killer cell activator, eosinophil granule major basic protein" 
    6. ^ PDB: 1h8u​; Swaminathan GJ, Weaver AJ, Loegering DA, Checkel JL, Leonidas DD, Gleich GJ, Acharya KR July 2001 "Crystal structure of the eosinophil major basic protein at 18 A An atypical lectin with a paradigm shift in specificity" J Biol Chem 276 28: 26197–26203 doi:101074/jbcM100848200 PMID 11319227 
    7. ^ PDB: 2brs​; Swaminathan GJ, Myszka DG, Katsamba PS, Ohnuki LE, Gleich GJ, Acharya KR November 2005 "Eosinophil-granule major basic protein, a C-type lectin, binds heparin" Biochemistry 44 43: 14152–14158 doi:101021/bi051112b PMID 16245931 
    8. ^ Overgaard, M T; Haaning J; Boldt H B; Olsen I M; Laursen L S; Christiansen M; Gleich G J; Sottrup-Jensen L; Conover C A; Oxvig C October 2000 "Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor" J Biol Chem UNITED STATES 275 40: 31128–31133 doi:101074/jbcM001384200 ISSN 0021-9258 PMID 10913121 
    9. ^ Overgaard MT, Sorensen ES, Stachowiak D, Boldt HB, Kristensen L, Sottrup-Jensen L, Oxvig C January 2003 "Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein Disulfide structure and carbohydrate attachment" J Biol Chem United States 278 4: 2106–2117 doi:101074/jbcM208777200 ISSN 0021-9258 PMID 12421832 
    10. ^ Oxvig, C; Sand O; Kristensen T; Gleich G J; Sottrup-Jensen L June 1993 "Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein" J Biol Chem UNITED STATES 268 17: 12243–6 ISSN 0021-9258 PMID 7685339 

    External links

    • Eosinophil+Major+Basic+Protein at the US National Library of Medicine Medical Subject Headings MeSH

    Further reading

    • Vanhaesebroeck B, Alessi DR 2000 "The PI3K-PDK1 connection: more than just a road to PKB" Biochem J 346 3: 561–76 doi:101042/0264-6021:3460561 PMC 1220886  PMID 10698680 
    • Yoshimatsu K, Ohya Y, Shikata Y, et al 1992 "Purification and cDNA cloning of a novel factor produced by a human T-cell hybridoma: sequence homology with animal lectins" Mol Immunol 29 4: 537–546 doi:101016/0161-58909290012-M PMID 1565101 
    • Barker RL, Loegering DA, Arakawa KC, et al 1990 "Cloning and sequence analysis of the human gene encoding eosinophil major basic protein" Gene 86 2: 285–289 doi:101016/0378-11199090292-Y PMID 2323577 
    • Gabay JE, Scott RW, Campanelli D, et al 1989 "Antibiotic proteins of human polymorphonuclear leukocytes" Proc Natl Acad Sci USA 86 14: 5610–5614 Bibcode:1989PNAS865610G doi:101073/pnas86145610 PMC 297672  PMID 2501794 
    • Wasmoen TL, McKean DJ, Benirschke K, et al 1990 "Evidence of eosinophil granule major basic protein in human placenta" J Exp Med 170 6: 2051–2063 doi:101084/jem17062051 PMC 2189540  PMID 2584934 
    • Barker RL, Gleich GJ, Pease LR 1988 "Acidic precursor revealed in human eosinophil granule major basic protein cDNA" J Exp Med 168 4: 1493–1498 doi:101084/jem16841493 PMC 2189086  PMID 3171483 
    • McGrogan M, Simonsen C, Scott R, et al 1989 "Isolation of a complementary DNA clone encoding a precursor to human eosinophil major basic protein" J Exp Med 168 6: 2295–2308 doi:101084/jem16862295 PMC 2189145  PMID 3199069 
    • Wasmoen TL, Bell MP, Loegering DA, et al 1988 "Biochemical and amino acid sequence analysis of human eosinophil granule major basic protein" J Biol Chem 263 25: 12559–63 PMID 3410852 
    • Weller PF, Ackerman SJ, Smith JA 1988 "Eosinophil granule cationic proteins: major basic protein is distinct from the smaller subunit of eosinophil peroxidase" J Leukoc Biol 43 1: 1–4 PMID 3422083 
    • Kristensen T, Oxvig C, Sand O, et al 1994 "Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA" Biochemistry 33 6: 1592–1598 doi:101021/bi00172a040 PMID 7508748 
    • Oxvig C, Haaning J, Højrup P, Sottrup-Jensen L 1994 "Location and nature of carbohydrate groups in proform of human major basic protein isolated from pregnancy serum" Biochem Mol Biol Int 33 2: 329–36 PMID 7524900 
    • Bonno M, Oxvig C, Kephart GM, et al 1994 "Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta" Lab Invest 71 4: 560–6 PMID 7526035 
    • Li MS, Sun L, Satoh T, et al 1995 "Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters" Biochem J 305 3: 921–7 PMC 1136346  PMID 7531438 
    • Oxvig C, Haaning J, Kristensen L, et al 1995 "Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma" J Biol Chem 270 23: 13645–13651 doi:101074/jbc2702313645 PMID 7539791 
    • Oxvig C, Sand O, Kristensen T, et al 1993 "Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein" J Biol Chem 268 17: 12243–6 PMID 7685339 
    • Levi-Schaffer F, Lacy P, Severs NJ, et al 1995 "Association of granulocyte-macrophage colony-stimulating factor with the crystalloid granules of human eosinophils" Blood 85 9: 2579–86 PMID 7727786 
    • Oxvig C, Gleich GJ, Sottrup-Jensen L 1994 "Localization of disulfide bridges and free sulfhydryl groups in human eosinophil granule major basic protein" FEBS Lett 341 2–3: 213–217 doi:101016/0014-57939480459-1 PMID 8137941 
    • Shikata Y, Hayashi Y, Yoshimatsu K, et al 1993 "Pro-major basic protein has three types of sugar chains at the pro-portion" Biochim Biophys Acta 1163 3: 243–9 doi:101016/0167-48389390158-N PMID 8507662 
    • Nittoh T, Watanabe M, Okayama H, et al 1996 "Cloning of cDNA for rat eosinophil major basic protein" Biochim Biophys Acta 1264 3: 261–4 doi:101016/0167-47819500183-2 PMID 8547309 
    • Delcommenne M, Tan C, Gray V, et al 1998 "Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase" Proc Natl Acad Sci USA 95 19: 11211–11216 Bibcode:1998PNAS9511211D doi:101073/pnas951911211 PMC 21621  PMID 9736715 

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