Lymphokine-activated killer celllymphokine-activated killer cell, lymphokine-activated killer cells
In cell biology, a lymphokine-activated killer cell also known as a LAK cell is a white blood cell that has been stimulated to kill tumor cells1 If lymphocytes are cultured in the presence of Interleukin 2, it results in the development of effector cells which are cytotoxic to tumor cells2
- 1 Mechanism
- 2 Cancer Treatment
- 3 Notes and references
- 4 External links
It has been shown that lymphocytes, when exposed to Interleukin 2, are capable of lysing fresh, non-cultured cancer cells, both primary and metastatic3 LAK cells respond to these lymphokines, particularly IL-2, by lysing tumor cells that were already known to be resistant to NK cell activity4
The mechanism of LAK cells is distinctive from that of natural killer cells because they can lyse cells that NK cells cannot4 LAK cells are also capable of acting against cells that do not display the major histocompatibility complex, as has been shown by the ability to cause lysis in non-immunogenic, allogeneic and syngeneic tumors4 LAK cells are specific to tumor cells and do not display activity against normal cells4
LAK cells, along with the administration of IL-2 have been experimentally used to treat cancer in mice and humans, but there is very high toxicity with this treatment5
Notes and referencesedit
- ^ "Definition of lymphokine-activated killer cell" National Cancer Institute Retrieved 2007-03-06
- ^ "Medical Dictionary: Lymphokine-activated killer cell" Wrong Diagnosis Retrieved 2007-03-06
- ^ E A Fagan and A L Eddleston 1987 "Immunotherapy for cancer: the use of lymphokine activated killer LAK cells" Gut 28 2: 113–116 PMC 1432985 PMID 3549471 doi:101136/gut282113
- ^ a b c d Lafreniere R, Rosenberg SA 1985 "Successful immunotherapy of murine experimental hepatic metastases with lymphokine-activated killer cells and recombinant Interleukin 2" Cancer Res 45: 3735–41
- ^ Rosenberg SA, Lotze MT, Muul LM, et al 1985 "Observations on the systemic administration of autologous lymohokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer" New England Journal of Medicine 313: 1485–92 PMID 3903508 doi:101056/nejm198512053132327
- Lymphokine-Activated Killer Cells at the US National Library of Medicine Medical Subject Headings MeSH
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