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Low copy repeats

low copy repeats, low copy number repeats
Low copy repeats LCRs, also known as segmental duplications SDs, are highly homologous sequence elements within the eukaryotic genome They are typically 10–300 kb in length, and bear greater than 95% sequence identity Though rare in most mammals, LCRs comprise a large portion of the human genome owing to a significant expansion during primate evolution[1]

Misalignment of LCRs during non-allelic homologous recombination NAHR[2] is an important mechanism underlying the chromosomal microdeletion disorders as well as their reciprocal duplication partners[3] Many LCRs are concentrated in "hotspots", such as the 17p11-12 region, 27% of which is composed of LCR sequence NAHR and non-homologous end joining NHEJ within this region are responsible for a wide range of disorders, including Charcot–Marie–Tooth syndrome type 1A,[4] hereditary neuropathy with liability to pressure palsies,[4] Smith–Magenis syndrome,[5] and Potocki–Lupski syndrome[2]

See also

  • Segmental duplication

References

  1. ^ Johnson, ME 2008 Primate Gene and Genome Evolution Driven by Segmental Duplication of Chromosome 16 PDF PhD Case Western Reserve University 
  2. ^ a b Zhang, F; Potocki, L; Sampson, JB; Liu, P; Sanchez-Valle, A; Robbins-Furman, P; Navarro, AD; Wheeler, PG; Spence, JE; Brasington, CK; Withers, MA; Lupski, JR 12 March 2010 "Identification of uncommon recurrent Potocki-Lupski syndrome-associated duplications and the distribution of rearrangement types and mechanisms in PTLS" PDF American Journal of Human Genetics 86 3: 462–70 doi:101016/jajhg201002001 PMC 2833368  PMID 20188345 
  3. ^ Shaikh, TH; Kurahashi, H; Saitta, SC; O'Hare, AM; Hu, P; Roe, BA; Driscoll, DA; McDonald-McGinn, DM; Zackai, EH; Budarf, ML; Emanuel, BS 1 March 2000 "Chromosome 22-specific low copy repeats and the 22q112 deletion syndrome: genomic organization and deletion endpoint analysis" Human Molecular Genetics 9 4: 489–501 doi:101093/hmg/94489 PMID 10699172 
  4. ^ a b Inoue, K; Dewar, K; Katsanis, N; Reiter, LT; Lander, ES; Devon, KL; Wyman, DW; Lupski, JR; Birren, B June 2001 "The 14-Mb CMT1A duplication/HNPP deletion genomic region reveals unique genome architectural features and provides insights into the recent evolution of new genes" Genome Research 11 6: 1018–33 doi:101101/gr180401 PMC 311111  PMID 11381029 
  5. ^ Shaw, CJ; Withers, MA; Lupski, JR July 2004 "Uncommon deletions of the Smith-Magenis syndrome region can be recurrent when alternate low-copy repeats act as homologous recombination substrates" American Journal of Human Genetics 75 1: 75–81 doi:101086/422016 PMC 1182010  PMID 15148657 


lcr low copy repeats, low copy number repeats, low copy repeats, what are low copy repeats


Low copy repeats Information about

Low copy repeats


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    Low copy repeats beatiful post thanks!

    29.10.2014


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