Löffler's syndrome

Löffler's syndrome or Loeffler's syndrome is a disease in which eosinophils accumulate in the lung in response to a parasitic infection

It was first described in 1932 by Wilhelm Löffler1 in cases of eosinophilic pneumonia caused by the parasites Ascaris lumbricoides,2 Strongyloides stercoralis and the hookworms Ancylostoma duodenale and Necator americanus

Although Löffler only described eosinophilic pneumonia in the context of infection, many authors give the term "Löffler's syndrome" to any form of acute onset pulmonary eosinophilia no matter what the underlying cause If the cause is unknown, it is specified and called "simple pulmonary eosinophilia" Cardiac damage caused by the damaging effects of eosinophil granule proteins ex major basic protein is known as Loeffler endocarditis and can be caused by idiopathic eosinophilia or eosinophilia in response to parasitic infectioncitation needed

See alsoedit

  • Eosinophilic pneumonia
  • Parasitic pneumonia
  • Pneumonia


  1. ^ Löffler, W 1932 "Zur Differential-Diagnose der Lungenifiltrierungen I Frühfiltrate unter besonerer Berücksichtigung der Rückbildungszeiten" Beiträge zum Klinik der Tuberkulose 79: 338–367 
    Löffler, W 1932 "Zur Differential-Diagnose der Lungenifiltrierungen II Über flüchtige Succedan-Infiltrate mit Eosinophilie" Beiträge zum Klinik der Tuberkulose 79: 368–382 
    Löffler, W 1935 "Flüchtige Lungeninfiltrate mit Eosinophilia" Klinische Wochenschrift 14 9: 297–9 doi:101007/BF01782394 
  2. ^ "Loeffler's syndrome" GPnotebook 

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