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lipopeptide antibiotics, lipopeptide
A lipopeptide is a molecule consisting of a lipid connected to a peptide Bacteria express these molecules They are able to self-assemble into different structures Certain lipopeptides are used as antibiotics Other lipopeptides are toll-like receptor agonists Certain lipopeptides can have strong antifungal and hemolytic activities It has been demonstrated that their activity is generally linked to interactions with the plasma membrane, and sterol components of the plasma membrane could play a major role in this interaction


  • 1 Examples
  • 2 See also
  • 3 References
  • 4 Further reading


  • Bacillomycins
  • Daptomycin
  • Echinocandins eg, caspofungin
  • Iturin A
  • Mycosubtilin
  • Surfactin

See also

  • Pepducins, lipopeptides aimed at GPCRs


  1. ^ a b Hamley, IW Lipopeptides: From Self-Assembly to Bioactivity Chem Comm 2015, 51, 8574-8583 doi: 101039/c5cc01535a
  2. ^ Kirkham, S; Castelletto, V; Hamley, I W; Inoue, K; Rambo, R; Reza, M; Ruokolainen, J, Self-Assembly of the Cyclic Lipopeptide Daptomycin: Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride Chemphyschem 2016, 17, 2118-2122doi:101002/cphc201600308
  3. ^ a b Hamley, I W; Kirkham, S; Dehsorkhi, A; Castelletto, V; Reza, M; Ruokolainen, J, Toll-Like Receptor Agonist Lipopeptides Self-Assemble into Distinct Nanostructuresdoi:101039/c4cc07511k
  4. ^ US Patent 6911525 - Lipopeptides as antibacterial agents
  5. ^ Daptomycin: a lipopeptide antibiotic for the treatment of serious Gram-positive infections , Judith N Steenbergen, Jeff Alder, Grace M Thorne and Francis P Tally , Journal of Antimicrobial Chemotherapy 2005 553:283-288; doi:101093/jac/dkh546
  6. ^ Maget-Dana, R, & Peypoux, F 1994 Iturins, a special class of pore-forming lipopeptides: biological and physicochemical properties Toxicology, 871-3, 151–74
  7. ^ Nasir, M N, Besson, F, & Deleu, M 2013 Interactions des antibiotiques ituriniques avec la membrane plasmique Apport des systèmes biomimétiques des membranes Biotechnology, Agronomy and Society and Environment, 173, 505–516
  8. ^ Nasir, M N, & Besson, F 2012 Interactions of the antifungal mycosubtilin with ergosterol-containing interfacial monolayers Biochimica et Biophysica Acta BBA - Biomembranes, 18185, 1302–1308
  9. ^ Nasir, M N, & Besson, F F 2011 Specific Interactions of Mycosubtilin with Cholesterol-Containing Artificial Membranes Langmuir : The ACS Journal of Surfaces and Colloids, 2717, 10785–10792

Further reading

  • Giuliani A, Pirri G, Nicoletto S 2007 "Antimicrobial peptides: an overview of a promising class of therapeutics" Cent Eur J Biol 2 1: 1–33 doi:102478/s11535-007-0010-5 
  • Pirri G, Giuliani A, Nicoletto S, Pizutto L, Rinaldi A 2009 "Lipopeptides as anti-infectives: a practical perspective" Cent Eur J Biol 4 3: 258–273 doi:102478/s11535-009-0031-3 

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    Lipopeptide beatiful post thanks!


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