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Knuckle pads

knuckle pads, knuckle pads on fingers
Knuckle pads also known as "Heloderma", meaning similar to the skin of the Gila monster lizard for which it is named are circumscribed, keratotic, fibrous growths over the dorsa of the interphalangeal joints 1 They are described as well-defined, round, plaque-like, fibrous thickening that may develop at any age, and grow to be 10 to 15mm in diameter in the course of a few weeks or months, then go away over time2

Knuckle pads are sometimes associated with Dupuytren's contracture and camptodactyly,2:595 and histologically, the lesions are fibromas2:595 Knuckle pads are generally non-responsive to treatment, including corticosteroids, and tend to recur after surgery; however, there has been some effectiveness with intralesional fluorouracil3


  1. ^ Mackey, SL; Cobb, MW 1994 "Knuckle pads" Cutis 54 3: 159–160 PMID 7813233 
  2. ^ a b c James, WD; Berger, TG; Elston, DM 2005 Andrews' Diseases of the Skin: Clinical Dermatology 11th ed Saunders p 595 ISBN 0-7216-2921-0  |access-date= requires |url= help
  3. ^ Weiss, E; Amini, S 2007 "A Novel Treatment for Knuckle Pads With Intralesional Fluorouracil" Arch Dermatol 143 11: 1447–1462 doi:101001/archderm143111458 

External Sourcesedit

  • Guberman D; et al 1996 ""Knuckle pads-a forgotten skin condition " report of a case and review of the literature" Cutis 57: 241 CS1 maint: Explicit use of et al link
  • Ly Y; et al 2003 "A novel mutation of keratin 9 in epidermolytic palmoplantar keratoderma combined with knuckle pads" Am J Med Genet 120A: 345 CS1 maint: Explicit use of et al link
  • Peterson CM; et al 2000 "Knuckle pads: does knuckle cracking play an etiologic role" Pediatr Dermatol 17: 450 doi:101046/j1525-1470200001819x CS1 maint: Explicit use of et al link

See alsoedit

  • Skin lesion
  • List of cutaneous conditions
  • Garrod's pad

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Knuckle pads

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