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Karl Deisseroth

karl deisseroth, karl deisseroth optogenetics
Karl Deisseroth born 18 November 1971 is the D H Chen Professor of Bioengineering and of Psychiatry and Behavioral Sciences at Stanford University He earned his AB in biochemical sciences from Harvard University and his MD/PhD in neuroscience from Stanford University in 1998, and completed medical internship and psychiatry residency at Stanford Medical School He is known for creating and developing the technologies of CLARITY and optogenetics, and for applying integrated optical and genetic strategies to study normal neural circuit function as well as dysfunction in neurological and psychiatric disease He has led his laboratory at Stanford University since 2004, serves as an attending physician at Stanford Hospital and Clinics, and has been affiliated with the Howard Hughes Medical Institute HHMI since 2009[1][2] Since 2014 he is a foreign Adjunct Professor at Sweden's prestigious Karolinska medical institute

Contents

  • 1 Research
  • 2 Honors and awards
  • 3 References
  • 4 External links

Research

In 2005 Deisseroth's laboratory, including graduate students Edward Boyden and Feng Zhang, published the first demonstration of the use of microbial opsin genes to achieve optogenetic control of neurons, allowing reliable control of action potentials with light at millisecond precision[3] Deisseroth named this field "optogenetics" in 2006 and followed up with optogenetic technology development work, leading to many applications including to psychiatry and neurology In 2010, the journal Nature Methods named optogenetics "Method of the Year"[4] In 2013, Deisseroth was senior author of a paper on a new technology named CLARITY, with first author postdoctoral fellow in his lab Kwanghun Chung, which makes biological tissues such as mammalian brains translucent and accessible to molecular probes[5][6]

On November 29, 2015, he was awarded the Breakthrough Prize in Life Sciences[7]

He has received the 2015 BBVA Foundation Frontiers of Knowledge Award in Biomedicine, jointly with Edward Boyden and Gero Miesenböck, for the development of optogenetics, the most precise technique for studying the brain today

Honors and awards

  • 2005 NIH Pioneer Award
  • 2010 HFSP Nakasone Award
  • 2010 Koetser Award
  • 2011 W Alden Spencer Award,[8]
  • 2012 Perl-UNC Neuroscience Prize
  • 2013 Goldman-Rakic Prize for Cognitive Neuroscience Research, Brain & Behavior Research Foundation
  • 2013 Richard Lounsbery Award
  • 2013 Jacob Heskel Gabbay Award[9]
  • 2013 Brain Prize, Lundbeckfonden[10]
  • 2014 Keio prize in medicine[11]
  • 2015 Albany Medical Center Prize[12]
  • 2015 Lurie Prize in Biomedical Sciences [13]
  • 2015 Breakthrough Prize in Life Sciences [7]
  • 2016 Harvey Prize [14]
  • 2016 Massry Prize
  • 2017 The Fresenius Research Prize
  • 2018 Gairdner Foundation International Award

Deisseroth is a member of the National Academy of Medicine, and the National Academy of Sciences Deisseroth is also a Brain & Behavior Research Foundation Scientific Council Member and NARSAD Grantee

References

  1. ^ "Karl Deisseroth, MD, PhD" HHMIorg Retrieved 2016-03-01 
  2. ^ Smith, Kerri 29 May 2013 "Neuroscience: Method man" Nature News Retrieved 27 February 2014 
  3. ^ Boyden ES; Zhang F; Bamberg E; Nagel G; Deisseroth K September 2005 "Millisecond-timescale, genetically targeted optical control of neural activity" Nature Neuroscience 8 9: 1263–8 doi:101038/nn1525 PMID 16116447 
  4. ^ "Method of the Year 2010" Nature Methods 8 1: 1–1 20 December 2010 doi:101038/nmethf321 
  5. ^ Brains as Clear as Jell-O for Scientists to Explore, April 10, 2013 The New York Times
  6. ^ Chung, Kwanghun; Wallace, Jenelle; Kim, Sung-Yon; Kalyanasundaram, Sandhiya; Andalman, Aaron S; Davidson, Thomas J; Mirzabekov, Julie J; Zalocusky, Kelly A; Mattis, Joanna; Denisin, Aleksandra K; Pak, Sally; Bernstein, Hannah; Ramakrishnan, Charu; Grosenick, Logan; Gradinaru, Viviana; Deisseroth, Karl 10 April 2013 "Structural and molecular interrogation of intact biological systems" Nature 497 7449: 332–337 doi:101038/nature12107 PMC 4092167  PMID 23575631 
  7. ^ a b "Breakthrough Prize" Breakthrough Prize Retrieved 2016-03-01 
  8. ^ "34th Annual W Alden Spencer Award and Lecture" Columbia University Retrieved 24 August 2012 
  9. ^ http://wwwbrandeisedu/rosenstiel/gabbayaward/pasthtml
  10. ^ http://wwwthebrainprizeorg/flx/prize_winners/prize_winners_2013/
  11. ^ Optogenetics earns Stanford professor Karl Deisseroth the Keio prize in medicine, Stanford, 2014
  12. ^ "Albany Medical College: AlbanyPrize" Amcedu 2015-08-14 Retrieved 2016-03-01 
  13. ^ "LURIE PRIZE OVERVIEW" Foundation for the National Institutes of Health Archived from the original on 1 September 2015 Retrieved 14 August 2015 
  14. ^ Harvey Prize 2016

External links

  • Academic home page, with links to resource pages
  • Howard Hughes Medical Institute bio
  • Stanford OTL Inventor Portfolio - Karl Deisseroth

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