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Ipodate sodium

ipodate sodium bicarbonate, ipodate sodium chloride
Ipodate sodium sodium iopodate is an iodine-containing radiopaque contrast media used for X-rays The drug is given orally and the resulting contrast allows for easy resolution of the bile duct and gall bladder

Contents

  • 1 Other uses
    • 11 Graves' disease
    • 12 Thyroid Storm
  • 2 References

Other uses

Although not FDA approved, ipodate sodium has been used to treat Graves' disease and thyroid storm, an extreme form of hyperthyroidism

Graves' disease

Long-term treatment of Graves' disease with ipodate sodium 500 mg, daily given by mouth reduced levels of T3 and T4 in the patients This was done with minimal side effects, indicating possible clinical usefulness Iodine uptake was also noted to return to normal within seven days, indicating control with ipodate with rapid follow up treatment with 131I is feasible

Thyroid Storm

In emergency situations, ipodate can be administered for thyroid storm As the ipodate is metabolized, it releases iodine into circulation, helping bring the T3 and T4 levels back down Ipodate also inhibits the conversion of T4 to T3 which is more potent It is not considered a first-line approach, as potassium iodide and beta blockers have less potential for side-effects Ipodate sodium lacks FDA approval for this use

References

  1. ^ DC Shen; SY Wu; IJ Chopra; HW Huang; LR Shian; TY Bian; CY Jeng; DH Solomon 1985 "Long term treatment of Graves' hyperthyroidism with sodium ipodate" Journal of Clinical Endocrinology & Metabolism 61 4: 723–727 doi:101210/jcem-61-4-723 PMID 3928675 

ipodate sodium bicarbonate, ipodate sodium carbonate, ipodate sodium chloride, ipodate sodium hydroxide


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Ipodate sodium


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