Tue . 19 May 2019

Interleukin 5

interleukin 5, interleukin 5 eosinophils
3VA2, 1HUL, 3QT2

Identifiers Aliases IL5, EDF, IL-5, TRF, interleukin 5 External IDs OMIM: 147850 MGI: 96557 HomoloGene: 679 GeneCards: IL5
Gene location Human
Chr Chromosome 5 human
Band 5q311 Start 132,541,444 bp
End 132,556,838 bp
RNA expression pattern
More reference expression data
Orthologs Species Human Mouse Entrez
RefSeq mRNA



RefSeq protein



Location UCSC Chr 5: 13254 – 13256 Mb Chr 11: 5372 – 5373 Mb PubMed search Wikidata
^ "Mouse PubMed Reference:" 
  • ^ Milburn MV, Hassell AM, Lambert MH, Jordan SR, Proudfoot AE, Graber P, Wells TN May 1993 "A novel dimer configuration revealed by the crystal structure at 24 A resolution of human interleukin-5" Nature 363 6425: 172–6 doi:101038/363172a0 PMID 8483502 
  • ^ Lee JS, Campbell HD, Kozak CA, Young IG March 1989 "The IL-4 and IL-5 genes are closely linked and are part of a cytokine gene cluster on mouse chromosome 11" Somat Cell Mol Genet 15 2: 143–52 doi:101007/BF01535075 PMID 2784591 
  • ^ van Leeuwen BH, Martinson ME, Webb GC, Young IG April 1989 "Molecular organization of the cytokine gene cluster, involving the human IL-3, IL-4, IL-5, and GM-CSF genes, on human chromosome 5" Blood 73 5: 1142–8 PMID 2564789 
  • ^ Dubucquoi S, Desreumaux P, Janin A, Klein O, Goldman M, Tavernier J, Capron A, Capron M February 1994 "Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion" J Exp Med 179 2: 703–8 doi:101084/jem1792703 PMC 2191391  PMID 8294877 
  • ^ Bradding P, Roberts JA, Britten KM, Montefort S, Djukanovic R, Mueller R, Heusser CH, Howarth PH, Holgate ST May 1994 "Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines" Am J Respir Cell Mol Biol 10 5: 471–80 doi:101165/ajrcmb1058179909 PMID 8179909 
  • ^ Kaminuma O, Mori A, Kitamura N, Hashimoto T, Kitamura F, Inokuma S, Miyatake S 2005 "Role of GATA-3 in IL-5 gene transcription by CD4+ T cells of asthmatic patients" Int Arch Allergy Immunol 137 Suppl 1: 55–9 doi:101159/000085433 PMID 15947486 
  • ^ Shen HH, Ochkur SI, McGarry MP, Crosby JR, Hines EM, Borchers MT, Wang H, Biechelle TL, O'Neill KR, Ansay TL, Colbert DC, Cormier SA, Justice JP, Lee NA, Lee JJ March 2003 "A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse" J Immunol 170 6: 3296–305 doi:104049/jimmunol17063296 PMID 12626589 
  • ^ Sanderson CJ June 1992 "Interleukin-5, eosinophils, and disease" Blood 79 12: 3101–9 PMID 1596561 
  • ^ Giembycz MA, Lindsay MA June 1999 "Pharmacology of the eosinophil" Pharmacol Rev 51 2: 213–340 PMID 10353986 
  • ^ Lopez AF, Begley CG, Williamson DJ, Warren DJ, Vadas MA, Sanderson CJ May 1986 "Murine eosinophil differentiation factor An eosinophil-specific colony-stimulating factor with activity for human cells" J Exp Med 163 5: 1085–99 doi:101084/jem16351085 PMC 2188112  PMID 3486243 
  • ^ Di Biagio E, Sánchez-Borges M, Desenne JJ, Suárez-Chacón R, Somoza R, Acquatella G Jul 1996 "Eosinophilia in Hodgkin's disease: a role for interleukin 5" Int Arch Allergy Immunol 110 3: 244–51 doi:101159/000237294 PMID 8688671 
  • ^ Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF November 1994 "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF" EMBO J 13 21: 5176–85 PMC 395466  PMID 7957082 
  • ^ Johanson K, Appelbaum E, Doyle M, Hensley P, Zhao B, Abdel-Meguid SS, Young P, Cook R, Carr S, Matico R April 1995 "Binding interactions of human interleukin 5 with its receptor alpha subunit Large scale production, structural, and functional studies of Drosophila-expressed recombinant proteins" J Biol Chem 270 16: 9459–71 doi:101074/jbc270169459 PMID 7721873 
  • ^ Murata Y, Takaki S, Migita M, Kikuchi Y, Tominaga A, Takatsu K February 1992 "Molecular cloning and expression of the human interleukin 5 receptor" J Exp Med 175 2: 341–51 doi:101084/jem1752341 PMC 2119102  PMID 1732409 
  • ^ a b Tavernier J, Devos R, Cornelis S, Tuypens T, Van der Heyden J, Fiers W, Plaetinck G September 1991 "A human high affinity interleukin-5 receptor IL5R is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF" Cell 66 6: 1175–84 doi:101016/0092-86749190040-6 PMID 1833065 
  • ^ Takaki S, Murata Y, Kitamura T, Miyajima A, Tominaga A, Takatsu K June 1993 "Reconstitution of the functional receptors for murine and human interleukin 5" J Exp Med 177 6: 1523–9 doi:101084/jem17761523 PMC 2191058  PMID 8496674 
  • ^ Ishino T, Economou NJ, McFadden K, Zaks-Zilberman M, Jost M, Baxter S, Contarino MR, Harrington AE, Loll PJ, Pasut G, Lievens S, Tavernier J, Chaiken I September 2011 "A protein engineering approach differentiates the functional importance of carbohydrate moieties of interleukin-5 receptor α" Biochemistry 50 35: 7546–56 doi:101021/bi2009135 PMID 21770429 
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