Thu . 18 Sep 2018

Interleukin 3

interleukin 3, interleukin 33
1JLI

Identifiers Aliases IL3, interleukin 3, IL-3, MCGF, MULTI-CSF External IDs OMIM: 147740 HomoloGene: 47938 GeneCards: IL3
Gene location Human
Chr Chromosome 5 human
Band 5q311 Start 132,060,529 bp
End 132,063,204 bp
RNA expression pattern
More reference expression data
Orthologs Species Human Mouse Entrez
Ensembl
UniProt
RefSeq mRNA

NM_000588

n/a

RefSeq protein

NP_000579

n/a

Location UCSC Chr 5: 13206 – 13206 Mb n/a PubMed search n/a Wikidata
^ "Entrez Gene: IL3 interleukin 3 colony-stimulating factor, multiple" 
  • ^ Yang YC, Ciarletta AB, Temple PA, Chung MP, Kovacic S, Witek-Giannotti JS, Leary AC, Kriz R, Donahue RE, Wong GG October 1986 "Human IL-3 multi-CSF: identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3" Cell 47 1: 3–10 doi:101016/0092-86748690360-0 PMID 3489530 
  • ^ Ihle JN, Pepersack L, Rebar L June 1981 "Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from athymic mice by a unique lymphokine" J Immunol 126 6: 2184–9 PMID 6971890 
  • ^ Ihle JN, Weinstein Y, Keller J, Henderson L, Palaszynski E 1985 "Interleukin 3" Meth Enzymol Methods in Enzymology 116: 540–52 doi:101016/S0076-68798516042-8 ISBN 978-0-12-182016-9 PMID 3003517 
  • ^ Stomski FC, Sun Q, Bagley CJ, Woodcock J, Goodall G, Andrews RK, Berndt MC, Lopez AF June 1996 "Human interleukin-3 IL-3 induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding" Mol Cell Biol 16 6: 3035–46 PMC 231298  PMID 8649415 
  • ^ Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF November 1994 "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF" EMBO J 13 21: 5176–85 PMC 395466  PMID 7957082 
  • Further reading

    • Wagemaker G, Burger H, van Gils FC, van Leen RW, Wielenga JJ 1990 "Interleukin-3" Biotherapy 2 4: 337–45 doi:101007/BF02170083 PMID 2268499 
    • Martinez-Moczygemba M, Huston DP 2003 "Biology of common beta receptor-signaling cytokines: IL-3, IL-5, and GM-CSF" J Allergy Clin Immunol 112 4: 653–65; quiz 666 doi:101016/jjaci200308015 PMID 14564341 
    • Mroczko B, Szmitkowski M 2004 "Hematopoietic cytokines as tumor markers" Clin Chem Lab Med 42 12: 1347–54 doi:101515/CCLM2004253 PMID 15576295 
    • Kitamura T, Sato N, Arai K, Miyajima A 1991 "Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors" Cell 66 6: 1165–74 doi:101016/0092-86749190039-2 PMID 1833064 
    • Urdal DL, Price V, Sassenfeld HM, Cosman D, Gillis S, Park LS 1989 "Molecular characterization of colony-stimulating factors and their receptors: human interleukin-3" Ann N Y Acad Sci 554: 167–76 doi:101111/j1749-66321989tb22418x PMID 2544122 
    • Otsuka T, Miyajima A, Brown N, Otsu K, Abrams J, Saeland S, Caux C, de Waal Malefijt R, de Vries J, Meyerson P 1988 "Isolation and characterization of an expressible cDNA encoding human IL-3 Induction of IL-3 mRNA in human T cell clones" J Immunol 140 7: 2288–95 PMID 3127463 
    • Yang YC, Ciarletta AB, Temple PA, Chung MP, Kovacic S, Witek-Giannotti JS, Leary AC, Kriz R, Donahue RE, Wong GG 1986 "Human IL-3 multi-CSF: identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3" Cell 47 1: 3–10 doi:101016/0092-86748690360-0 PMID 3489530 
    • Le Beau MM, Epstein ND, O'Brien SJ, Nienhuis AW, Yang YC, Clark SC, Rowley JD 1987 "The interleukin 3 gene is located on human chromosome 5 and is deleted in myeloid leukemias with a deletion of 5q" Proc Natl Acad Sci USA 84 16: 5913–7 doi:101073/pnas84165913 PMC 298973  PMID 3497400 
    • Dorssers L, Burger H, Bot F, Delwel R, Geurts van Kessel AH, Löwenberg B, Wagemaker G 1987 "Characterization of a human multilineage-colony-stimulating factor cDNA clone identified by a conserved noncoding sequence in mouse interleukin-3" Gene 55 1: 115–24 doi:101016/0378-11198790254-X PMID 3497843 
    • Chirmule N, Goonewardena H, Pahwa S, Pasieka R, Kalyanaraman VS, Pahwa S 1995 "HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells" J Biol Chem 270 33: 19364–9 doi:101074/jbc2703319364 PMID 7642615 
    • Than S, Oyaizu N, Pahwa RN, Kalyanaraman VS, Pahwa S 1994 "Effect of human immunodeficiency virus type-1 envelope glycoprotein gp160 on cytokine production from cord-blood T cells" Blood 84 1: 184–8 PMID 8018916 
    • Le Beau MM, Espinosa R, Neuman WL, Stock W, Roulston D, Larson RA, Keinanen M, Westbrook CA 1993 "Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases" Proc Natl Acad Sci USA 90 12: 5484–8 doi:101073/pnas90125484 PMC 46745  PMID 8516290 
    • Stomski FC, Sun Q, Bagley CJ, Woodcock J, Goodall G, Andrews RK, Berndt MC, Lopez AF 1996 "Human interleukin-3 IL-3 induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding" Mol Cell Biol 16 6: 3035–46 PMC 231298  PMID 8649415 
    • Feng Y, Klein BK, McWherter CA 1996 "Three-dimensional solution structure and backbone dynamics of a variant of human interleukin-3" J Mol Biol 259 3: 524–41 doi:101006/jmbi19960337 PMID 8676386 
    • Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD 1997 "P110delta, a novel phosphoinositide 3-kinase in leukocytes" Proc Natl Acad Sci USA 94 9: 4330–5 doi:101073/pnas9494330 PMC 20722  PMID 9113989 
    • Klein BK, Feng Y, McWherter CA, Hood WF, Paik K, McKearn JP 1997 "The receptor binding site of human interleukin-3 defined by mutagenesis and molecular modeling" J Biol Chem 272 36: 22630–41 doi:101074/jbc2723622630 PMID 9278420 
    • Sanchez X, Suetomi K, Cousins-Hodges B, Horton JK, Navarro J 1998 "CXC chemokines suppress proliferation of myeloid progenitor cells by activation of the CXC chemokine receptor 2" J Immunol 160 2: 906–10 PMID 9551928 
    • Tabira T, Chui DH, Fan JP, Shirabe T, Konishi Y 1998 "Interleukin-3 and interleukin-3 receptors in the brain" Ann N Y Acad Sci 840: 107–16 doi:101111/j1749-66321998tb09554x PMID 9629242 
    • Nilsen EM, Johansen FE, Jahnsen FL, Lundin KE, Scholz T, Brandtzaeg P, Haraldsen G 1998 "Cytokine profiles of cultured microvascular endothelial cells from the human intestine" Gut 42 5: 635–42 doi:101136/gut425635 PMC 1727090  PMID 9659156 

    interleukin 3, interleukin 3 pathway, interleukin 3 receptor, interleukin 31, interleukin 31 and atopic dermatitis, interleukin 33, interleukin 35, interleukin 36, interleukin 37, interleukin 38


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      Interleukin 3 beatiful post thanks!

      29.10.2014


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